Manuel Bange absolvierte sein Studium der Sportwissenschaften an der Johannes Gutenberg-Universität Mainz mit besonderem Interesse an den Bereichen der motorischen Kontrolle und des motorischen Lernens. Er promovierte 2022 in der Arbeitsgruppe für Bewegungsstörungen, Neuroimaging und Neurostimulation der Klinik und Poliklinik für Neurologie am Universitätsklinikum Mainz zum Thema " Characterization of functional and structural brain alterations related to movement impairments in Parkinson’s disease". Seit 2024 ist er als wissenschaftlicher Mitarbeiter am Lehrstuhl für Informatik in der Medizintechnik tätig und forscht unter anderem an der Optimierung der biomechanischen Charakterisierung des Gehens, vor allem vor dem Hintergrund der Beschreibung neurophysiologischer Korrelate.

Publikationen

1. Bange M, Herz DM, Ciolac D, Gonzalez-Escamilla G, Groppa S. Modifying the progression of Parkinson's disease through movement interventions: multimodal quantification of underlying mechanisms. Neural Regen Res. 2024 Aug 1;19(8):1651-1652. doi: 10.4103/1673-5374.389633. Epub 2023 Dec 11. PMID: 38103225.
2. Bange M, Gonzalez-Escamilla G, Lang NSC, Ding H, Radetz A, Herz DM, Schöllhorn WI, Muthuraman M, Groppa S. Gait Abnormalities in Parkinson's Disease Are Associated with Extracellular Free-Water Characteristics in the Substantia Nigra. J Parkinsons Dis. 2022;12(5):1575-1590. doi: 10.3233/JPD-223225. PMID: 35570500.
3. Bange M, Gonzalez-Escamilla G, Marquardt T, Radetz A, Dresel C, Herz D, Schöllhorn WI, Groppa S, Muthuraman M. Deficient Interhemispheric Connectivity Underlies Movement Irregularities in Parkinson's Disease. J Parkinsons Dis. 2022;12(1):381-395. doi: 10.3233/JPD-212840. PMID: 34719510.
4. Bange M, Groppa S, Muthuraman M. Nonlinear irregularities in Parkinson's disease tremor and essential tremor. Clin Neurophysiol. 2021 Sep;132(9):2255-2256. doi: 10.1016/j.clinph.2021.06.002. Epub 2021 Jun 18. PMID: 34238677.
5. Herz DM, Bange M, Gonzalez-Escamilla G, Auer M, Muthuraman M, Glaser M, Bogacz R, Pogosyan A, Tan H, Groppa S, Brown P. Dynamic modulation of subthalamic nucleus activity facilitates adaptive behavior. PLoS Biol. 2023 Jun 1;21(6):e3002140. doi: 10.1371/journal.pbio.3002140. PMID: 37262014; PMCID: PMC10234560.
6. Herz DM, Bange M, Gonzalez-Escamilla G, Auer M, Ashkan K, Fischer P, Tan H, Bogacz R, Muthuraman M, Groppa S, Brown P. Dynamic control of decision and movement speed in the human basal ganglia. Nat Commun. 2022 Dec 7;13(1):7530. doi: 10.1038/s41467-022-35121-8. PMID: 36476581; PMCID: PMC9729212.
7. Leahu P, Bange M, Ciolac D, Scheiter S, Matei A, Gonzalez-Escamilla G, Chirumamilla VC, Groppa SA, Muthuraman M, Groppa S. Increased migraine-free intervals with multifocal repetitive transcranial magnetic stimulation. Brain Stimul. 2021 Nov-Dec;14(6):1544-1552. doi: 10.1016/j.brs.2021.10.383. Epub 2021 Oct 18. PMID: 34673259.
8. Muthuraman M, Bange M, Koirala N, Ciolac D, Pintea B, Glaser M, Tinkhauser G, Brown P, Deuschl G, Groppa S. Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson's disease. Brain. 2020 Dec 5;143(11):3393-3407. doi: 10.1093/brain/awaa297. PMID: 33150359; PMCID: PMC7116448.
9. Muthuraman M, Bange M, Groppa S. Advanced technologies for detecting tremor in Parkinson's disease. Clin Neurophysiol. 2020 Jan;131(1):241-242. doi: 10.1016/j.clinph.2019.11.006. Epub 2019 Nov 21. PMID: 31806418.
10. Gonzalez-Escamilla G, Koirala N, Bange M, Glaser M, Pintea B, Dresel C, Deuschl G, Muthuraman M, Groppa S. Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease. Neurol Ther. 2022 Jan 9. doi: 10.1007/s40120-021-00318-4. Epub ahead of print. PMID: 35000133.
11. Ding H, Droby A, Anwar AR, Bange M, Hausdorff JM, Nasseroleslami B, Mirelman A, Maidan I, Groppa S, Muthuraman M. Treadmill training in Parkinson's disease is underpinned by the interregional connectivity in cortical-subcortical network. NPJ Parkinsons Dis. 2022 Nov 11;8(1):153. doi: 10.1038/s41531-022-00427-3. PMID: 36369264; PMCID: PMC9652466.
12. Wiest C, Tinkhauser G, Pogosyan A, Bange M, Muthuraman M, Groppa S, Baig F, Mostofi A, Pereira EA, Tan H, Brown P, Torrecillos F. Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Neurobiol Dis. 2020 Sep;143:105019. doi: 10.1016/j.nbd.2020.105019. Epub 2020 Jul 16. PMID: 32681881; PMCID: PMC7115855.
13. Wiest C, Torrecillos F, Pogosyan A, Bange M, Muthuraman M, Groppa S, Hulse N, Hasegawa H, Ashkan K, Baig F, Morgante F, Pereira EA, Mallet N, Magill PJ, Brown P, Sharott A, Tan H. The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism. Elife. 2023 Feb 22;12:e82467. doi: 10.7554/eLife.82467. PMID: 36810199; PMCID: PMC10005762.
14. Tinkhauser G, Torrecillos F, Pogosyan A, Mostofi A, Bange M, Fischer P, Tan H, Hasegawa H, Glaser M, Muthuraman M, Groppa S, Ashkan K, Pereira EA, Brown P. The Cumulative Effect of Transient Synchrony States on Motor Performance in Parkinson's Disease. J Neurosci. 2020 Feb 12;40(7):1571-1580. doi: 10.1523/JNEUROSCI.1975-19.2019. Epub 2020 Jan 9. PMID: 31919131; PMCID: PMC7044725.
15. Alva L, Bernasconi E, Torrecillos F, Fischer P, Averna A, Bange M, Mostofi A, Pogosyan A, Ashkan K, Muthuraman M, Groppa S, Pereira EA, Tan H, Tinkhauser G. Clinical neurophysiological interrogation of motor slowing: A critical step towards tuning adaptive deep brain stimulation. Clin Neurophysiol. 2023 Aug;152:43-56. doi: 10.1016/j.clinph.2023.04.013. Epub 2023 May 16. PMID: 37285747.
16. Groppa S, Gonzalez-Escamilla G, Tinkhauser G, Baqapuri HI, Sajonz B, Wiest C, Pereira J, Herz DM, Dold MR, Bange M, Ciolac D, Almeida V, Neuber J, Mirzac D, Martín-Rodríguez JF, Dresel C, Muthuraman M, Adarmes Gomez AD, Navas M, Temiz G, Gunduz A, Rotaru L, Winter Y, Schuurman R, Contarino MF, Glaser M, Tangermann M, Leentjens AFG, Mir P, Torres Diaz CV, Karachi C, Linden DEJ, Tan H, Coenen VA; EuroDBS. Perspectives of Implementation of Closed-Loop Deep Brain Stimulation: From Neurological to Psychiatric Disorders. Stereotact Funct Neurosurg. 2023 Dec 12:1-15. doi: 10.1159/000535114. Epub ahead of print. PMID: 38086346.

Kongressbeiträge

1. Bange M, Gonzalez-Escamilla G, Herz DM, Tinkhauser G, Glaser M, Ciolac D, Tan H, Brown P, Groppa S. Deep brain stimulation modulates subthalamic beta bursts related to movement velocity adjustments in Parkinson’s disease. MDS International Congress 2023, 27-31. August, 2023, Kopenhagen, Dänemark
2. Bange M, Gonzalez-Escamilla G, Herz DM, Tinkhauser G, Pogosyan A, Glaser M, Ciolac D, Dresel C, Tan H, Brown P, Groppa S. The modulation of subthalamic beta bursts during task execution underlies deep brain stimulation related motor improvement in Parkinson’s disease. World Parkinson Congress 2023, 4-7. July, 2023, Barcelona, Spanien
3. Bange M, Gonzalez-Escamilla G, Lang N, Radetz A, Ding H, Herz DM, Schöllhorn W, Muthuraman M, Groppa S. Gait abnormalities relate to increased extracellular water in the substantia nigra in Parkinson’s disease patients. MDS International Congress 2023, 15-18. September, 2022, Madrid, Spanien
4. Bange M, Gonzalez-Escamilla G, Marquardt T, Radetz A, Dresel C, Herz DM, Schöllhorn WI, Groppa S, Muthuraman M. Deficient interhemispheric connectivity underlies movement irregularities in Parkinson’s disease. MDS Virtual Congress, 17-22. Septemer, 2021
5. Bange M, Lang N, Gonzalez-Escamilla G, Radetz A, Dresel C, Muthuraman M, Groppa S. Brain microstructural integrity relates to walking impairment in Parkinson’s disease. 94. Kongress der deutschen Gesellschaft für Neurologie, 3.-6. November, 2021
6. Muthuraman M, Bange M, Koirala N, Pintea B, Glaser M, Groppa S. Effective deep brain stimulation co-modulate cross-frequency coupling of narrowband gamma frequencies to the stimulation frequency in a cortical-subcortical network. Deutscher Kongress für Parkinson und Bewegungsstörungen, 7-9. März, 2019, Düsseldorf, Deutschland
7. Bange M, André G, Henz D. Motor and Neural Adaptation during an Eight-Week Writing Training with the Non-Preferred Hand. Book of Abstracts of the 4^th International Congress on Sports Sciences Research and Technology Support, 7-9. November, 2016, Porto, Portugal