Forschungsschwerpunkt Diabetische Nephropathie
Diabetische Nephropathie ist eine Nierenerkrankung, die als Komplikation des Diabetes mellitus auftritt. Sie stellt eine der häufigsten Ursachen für Nierenversagen dar und ist eine der Hauptursachen für Morbidität und Mortalität bei Menschen mit Diabetes.
Durch den Einsatz innovativer Modelle und modernster Sequenzierungsmethoden untersuchen wir bislang unbekannte Mechanismen, die die Entstehung der diabetischen Nephropathie fördern. Unser Ziel ist es, darauf aufbauend neue therapeutische Zielstrukturen zu identifizieren.Forschungsschwerpunkt Adipositas- und Diabetestherapien
Bei starkem Übergewicht sind operative Eingriffe wie Magenbypass oder Schlauchmagen häufig die einzige effektive Lösung für eine langfristige Gewichtsreduktion. Neuartige Inkretin-Mimetika bieten jedoch eine vielversprechende therapeutische Alternative. Diese Medikamente greifen in die natürlichen Signalwege des Körpers ein, um den Blutzuckerspiegel zu regulieren und das Gewicht zu reduzieren. Unsere Forschung konzentriert sich auf die präzise Analyse der komplexen molekularen Signalwege, die die Wirksamkeit und potenziellen Nebenwirkungen der Inkretin-Mimetika beeinflussen.
Forschungsschwerpunkt Einfluss von Umweltfaktoren auf Stoffwechselerkrankungen
Hohe Temperaturen und Hitzewellen stellen ein erhebliches Risiko für Menschen mit Übergewicht und Diabetes dar. In verschiedenen Modellsystemen untersuchen wir die molekularbiologischen Mechanismen, durch die Temperaturveränderungen die Stoffwechselprozesse sowohl im gesunden als auch im metabolisch beeinträchtigten Zustand beeinflussen. Unsere Forschung ist entscheidend, um neue Ansätze zur Prävention und Behandlung hitzebedingter Gesundheitsprobleme bei Übergewicht und Diabetes zu entwickeln und damit ihre Lebensqualität nachhaltig zu verbessern.
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Publikationen
2024
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2023
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2022
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2021
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2020
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2019
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2018
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2017
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2016
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2015
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2014
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2013
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2012
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2011
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2010
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2009
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2007
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2006
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2024 |
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Lark Daniel Stephen, Stemmer Kerstin, Ying Wei, Crewe Clair.
A brief guide to studying extracellular vesicle function in the context of metabolism.
https://doi.org/10.1038/s42255-024-01112-w
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Krause Christin, Britsemmer Jan H., Bernecker Miriam, Molenaar Anna, Taege Natalie, Geißler Cathleen, Kaehler Meike, Iben Katharina, Judycka Anna, Wagner Jonas, Wolter Stefan, Mann Oliver, Pfluger Paul T., Cascorbi Ingolf, Lehnert Hendrik, Stemmer Kerstin, Schriever Sonja C., Kirchner Henriette.
Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity.
https://doi.org/10.7554/eLife.92075
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Welsh Joshua A., Goberdhan Deborah C. I., O'Driscoll Lorraine, Buzas Edit I., Blenkiron Cherie, Bussolati Benedetta, Cai Houjian, Di Vizio Dolores, Driedonks Tom A. P., Erdbrügger Uta, Falcon‐Perez Juan M., Fu Qing‐Ling, Hill Andrew F., Lenassi Metka, Lim Sai Kiang, Mahoney Mỹ G., Mohanty Sujata, Möller Andreas, Nieuwland Rienk, Ochiya Takahiro, Sahoo Susmita, Torrecilhas Ana C., Zheng Lei, Zijlstra Andries, Abuelreich Sarah, Bagabas Reem, Bergese Paolo, Bridges Esther M., Brucale Marco, Burger Dylan, Carney Randy P., Cocucci Emanuele, Crescitelli Rossella, Hanser Edveena, Harris Adrian L., Haughey Norman J., Hendrix An, Ivanov Alexander R., Jovanovic‐Talisman Tijana, Kruh‐Garcia Nicole A., Ku'ulei‐Lyn Faustino Vroniqa, Kyburz Diego, Lässer Cecilia, Lennon Kathleen M., Lötvall Jan, Maddox Adam L., Martens‐Uzunova Elena S., Mizenko Rachel R., Newman Lauren A., Ridolfi Andrea, Rohde Eva, Rojalin Tatu, Rowland Andrew, Saftics Andras, Sandau Ursula S., Saugstad Julie A., Shekari Faezeh, Swift Simon, Ter‐Ovanesyan Dmitry, Tosar Juan P., Useckaite Zivile, Valle Francesco, Varga Zoltan, van der Pol Edwin, van Herwijnen Martijn J. C., Wauben Marca H. M., Wehman Ann M., Williams Sarah, Zendrini Andrea, Zimmerman Alan J., Théry Clotilde, Witwer Kenneth W., Kulaj Konxhe.
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches.
https://doi.org/10.1002/jev2.12404
PDF | BibTeX | RIS | DOI For a full list of the MISEV Consortium please visit: https://doi.org/10.1002/jev2.12404 A correction to this article was published under: https://doi.org/10.1002/jev2.12451 |
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2023 |
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Glunk Viktoria, Laber Samantha, Sinnott-Armstrong Nasa, Sobreira Debora R., Strobel Sophie M., Batista Thiago M., Kubitz Phil, Moud Bahareh Nemati, Ebert Hannah, Huang Yi, Brandl Beate, Garbo Garrett, Honecker Julius, Stirling David R., Abdennur Nezar, Calabuig-Navarro Virtu, Skurk Thomas, Ocvirk Soeren, Stemmer Kerstin, Cimini Beth A., Carpenter Anne E., Dankel Simon N., Lindgren Cecilia M., Hauner Hans, Nobrega Marcelo A., Claussnitzer Melina.
A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes.
https://doi.org/10.1038/s42255-023-00807-w
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Kulaj Konxhe, Harger Alexandra, Bauer Michaela, Caliskan Özüm S., Gupta Tilak Kumar, Chiang Dapi Menglin, Milbank Edward, Reber Josefine, Karlas Angelos, Kotzbeck Petra, Sailer David N., Volta Francesco, Lutter Dominik, Prakash Sneha, Merl-Pham Juliane, Ntziachristos Vasilis, Hauner Hans, Pfaffl Michael W., Tschöp Matthias H., Müller Timo D., Hauck Stefanie M., Engel Benjamin D., Gerdes Jantje M., Pfluger Paul T., Krahmer Natalie, Stemmer Kerstin.
Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo.
https://doi.org/10.1038/s41467-023-36148-1
PDF | BibTeX | RIS | DOI These authors contributed equally: Konxhe Kulaj, Alexandra Harger, Michaela Bauer, Özüm S. Caliskan |
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Stemmer Kerstin, Müller Timo D..
GLP-1-Mimetika — wegweisend zur Behandlung von Diabetes und Adipositas.
https://doi.org/10.1007/s12268-023-1919-6
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2022 |
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Abuhattum Shada, Kotzbeck Petra, Schlüßler Raimund, Harger Alexandra, Ariza de Schellenberger Angela, Kim Kyoohyun, Escolano Joan-Carles, Müller Torsten, Braun Jürgen, Wabitsch Martin, Tschöp Matthias, Sack Ingolf, Brankatschk Marko, Guck Jochen, Stemmer Kerstin, Taubenberger Anna V..
Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens.
https://doi.org/10.1038/s41598-022-13324-9
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Quarta Carmelo, Stemmer Kerstin, Novikoff Aaron, Yang Bin, Klingelhuber Felix, Harger Alex, Bakhti Mostafa, Bastidas-Ponce Aimee, Baugé Eric, Campbell Jonathan E., Capozzi Megan, Clemmensen Christoffer, Collden Gustav, Cota Perla, Douros Jon, Drucker Daniel J., DuBois Barent, Feuchtinger Annette, Garcia-Caceres Cristina, Grandl Gerald, Hennuyer Nathalie, Herzig Stephan, Hofmann Susanna M., Knerr Patrick J., Kulaj Konxhe, Lalloyer Fanny, Lickert Heiko, Liskiewicz Arek, Liskiewicz Daniela, Maity Gandhari, Perez-Tilve Diego, Prakash Sneha, Sanchez-Garrido Miguel A., Zhang Qian, Staels Bart, Krahmer Natalie, DiMarchi Richard D., Tschöp Matthias H., Finan Brian, Müller Timo D..
GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.
https://doi.org/10.1038/s42255-022-00617-6
PDF | BibTeX | RIS | DOI These authors contributed equally: Carmelo Quarta, Kerstin Stemmer, Aaron Novikoff |
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Evers Simon S., Shao Yikai, Ramakrishnan Sadeesh K., Shin Jae Hoon, Bozadjieva-Kramer Nadejda, Irmler Martin, Stemmer Kerstin, Sandoval Darleen A., Shah Yatrik M., Seeley Randy J..
Gut HIF2α signaling is increased after VSG, and gut activation of HIF2α decreases weight, improves glucose, and increases GLP-1 secretion.
https://doi.org/10.1016/j.celrep.2021.110270
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2021 |
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Aliluev Alexandra, Tritschler Sophie, Sterr Michael, Oppenländer Lena, Hinterdobler Julia, Greisle Tobias, Irmler Martin, Beckers Johannes, Sun Na, Walch Axel, Stemmer Kerstin, Kindt Alida, Krumsiek Jan, Tschöp Matthias H., Luecken Malte D., Theis Fabian J., Lickert Heiko, Böttcher Anika.
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice.
https://doi.org/10.1038/s42255-021-00458-9
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Novikoff Aaron, O'Brien Shannon L., Bernecker Miriam, Grandl Gerald, Kleinert Maximilian, Knerr Patrick J., Stemmer Kerstin, Klingenspor Martin, Zeigerer Anja, DiMarchi Richard, Tschöp Matthias H., Finan Brian, Calebiro Davide, Müller Timo D..
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists.
https://doi.org/10.1016/j.molmet.2021.101181
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Zhang Qian, Delessa Challa Tenagne, Augustin Robert, Bakhti Mostafa, Colldén Gustav, Drucker Daniel J., Feuchtinger Annette, Caceres Cristina Garcia, Grandl Gerald, Harger Alexandra, Herzig Stephan, Hofmann Susanna, Holleman Cassie Lynn, Jastroch Martin, Keipert Susanne, Kleinert Maximilian, Knerr Patrick J., Kulaj Konxhe, Legutko Beata, Lickert Heiko, Liu Xue, Luippold Gerd, Lutter Dominik, Malogajski Emilija, Medina Marta Tarquis, Mowery Stephanie A., Blutke Andreas, Perez-Tilve Diego, Salinno Ciro, Sehrer Laura, DiMarchi Richard D., Tschöp Matthias H., Stemmer Kerstin, Finan Brian, Wolfrum Christian, Müller Timo D..
The Glucose-dependent Insulinotropic Polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.
https://doi.org/10.1016/j.cmet.2021.01.015
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Oppenländer Lena, Palit Subarna, Stemmer Kerstin, Greisle Tobias, Sterr Michael, Salinno Ciro, Bastidas-Ponce Aimée, Feuchtinger Annette, Böttcher Anika, Ansarullah , Theis Fabian J., Lickert Heiko.
Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes.
https://doi.org/10.1016/j.molmet.2021.101330
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2020 |
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Stemmer Kerstin, Finan Brian, DiMarchi Richard D., Tschöp Matthias H., Müller Timo D..
Insights into incretin-based therapies for treatment of diabetic dyslipidemia.
https://doi.org/10.1016/j.addr.2020.05.008
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Jall Sigrid, De Angelis Meri, Lundsgaard Anne-Marie, Fritzen Andreas M., Nicolaisen Trine S., Klein Anders B., Novikoff Aaron, Sachs Stephan, Richter Erik A., Kiens Bente, Schramm Karl-Werner, Tschöp Matthias H., Stemmer Kerstin, Clemmensen Christoffer, Müller Timo D., Kleinert Maximilian.
Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity.
https://doi.org/10.1007/s00125-020-05117-4
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Sachs Stephan, Niu Lili, Geyer Philipp, Jall Sigrid, Kleinert Maximilian, Feuchtinger Annette, Stemmer Kerstin, Brielmeier Markus, Finan Brian, DiMarchi Richard D., Tschöp Matthias H., Wewer Albrechtsen Nicolai, Mann Matthias, Müller Timo D., Hofmann Susanna M..
Plasma proteome profiles treatment efficacy of incretin dual agonism in diet‐induced obese female and male mice.
https://doi.org/10.1111/dom.14215
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Fischer Katrin, Fenzl Anna, Liu Dianxin, Dyar Kenneth A., Kleinert Maximilian, Brielmeier Markus, Clemmensen Christoffer, Fedl Anna, Finan Brian, Gessner Andre, Jastroch Martin, Huang Jianfeng, Keipert Susanne, Klingenspor Martin, Brüning Jens C., Kneilling Manfred, Maier Florian C., Othman Ahmed E., Pichler Bernd J., Pramme-Steinwachs Ines, Sachs Stephan, Scheideler Angelika, Thaiss Wolfgang M., Uhlenhaut Henriette, Ussar Siegfried, Woods Stephen C., Zorn Julia, Stemmer Kerstin, Collins Sheila, Diaz-Meco Maria, Moscat Jorge, Tschöp Matthias H., Müller Timo D..
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.
https://doi.org/10.1038/s41467-020-16230-8
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Schriever Sonja C., Kabra Dhiraj G., Pfuhlmann Katrin, Baumann Peter, Baumgart Emily V., Nagler Joachim, Seebacher Fabian, Harrison Luke, Irmler Martin, Kullmann Stephanie, Corrêa-da-Silva Felipe, Giesert Florian, Jain Ruchi, Schug Hannah, Castel Julien, Martinez Sarah, Wu Moya, Häring Hans-Ulrich, de Angelis Martin Hrabe, Beckers Johannes, Müller Timo D., Stemmer Kerstin, Wurst Wolfgang, Rozman Jan, Nogueiras Ruben, De Angelis Meri, Molkentin Jeffery D., Krahmer Natalie, Yi Chun-Xia, Schmidt Mathias V., Luquet Serge, Heni Martin, Tschöp Matthias H., Pfluger Paul T..
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
https://doi.org/10.1172/jci136363
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2019 |
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Stemmer Kerstin, Müller Timo D., DiMarchi Richard D., Pfluger Paul T., Tschöp Matthias H..
CNS-targeting pharmacological interventions for the metabolic syndrome.
https://doi.org/10.1172/jci129195
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Müller Günter A., Herling Andreas W., Stemmer Kerstin, Lechner Andreas, Tschöp Matthias H..
Chip-based sensing for release of unprocessed cell surface proteins in vitro and in serum and its (patho)physiological relevance.
https://doi.org/10.1152/ajpendo.00079.2019
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Bastek Heinke, Zubel Tabea, Stemmer Kerstin, Mangerich Aswin, Beneke Sascha, Dietrich Daniel R..
Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity models.
https://doi.org/10.1016/j.tox.2019.03.013
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Müller T.D., Finan B., Bloom S.R., D'Alessio D., Drucker D.J., Flatt P.R., Fritsche A., Gribble F., Grill H.J., Habener J.F., Holst J.J., Langhans W., Meier J.J., Nauck M.A., Perez-Tilve D., Pocai A., Reimann F., Sandoval D.A., Schwartz T.W., Seeley R.J., Stemmer Kerstin, Tang-Christensen M., Woods S.C., DiMarchi R.D., Tschöp M.H..
Glucagon-like peptide 1 (GLP-1).
https://doi.org/10.1016/j.molmet.2019.09.010
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Seitz Susanne, Kwon Yun, Hartleben Götz, Jülg Julia, Sekar Revathi, Krahmer Natalie, Najafi Bahar, Loft Anne, Gancheva Sofiya, Stemmer Kerstin, Feuchtinger Annette, Hrabe de Angelis Martin, Müller Timo D., Mann Matthias, Blüher Matthias, Roden Michael, Berriel Diaz Mauricio, Behrends Christian, Gilleron Jerome, Herzig Stephan, Zeigerer Anja.
Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity.
https://doi.org/10.1038/s42255-019-0124-x
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Harger A., Stemmer Kerstin, Tschöp M. H., Müller T. D..
Inkretinbasierte Ko- und Triagonisten: innovative Polypharmakologie zur Behandlung von Adipositas und Diabetes.
https://doi.org/10.1007/s00108-019-0649-9
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Niu Lili, Geyer Philipp E, Wewer Albrechtsen Nicolai J, Gluud Lise L, Santos Alberto, Doll Sophia, Treit Peter V, Holst Jens J, Knop Filip K, Vilsbøll Tina, Junker Anders, Sachs Stephan, Stemmer Kerstin, Müller Timo D, Tschöp Matthias H, Hofmann Susanna M, Mann Matthias.
Plasma proteome profiling discovers novel proteins associated with non‐alcoholic fatty liver disease.
https://doi.org/10.15252/msb.20188793
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2018 |
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Rahn Sascha, Zimmermann Vivien, Viol Fabrice, Knaack Hendrike, Stemmer Kerstin, Peters Lena, Lenk Lennart, Ungefroren Hendrik, Saur Dieter, Schäfer Heiner, Helm Ole, Sebens Susanne.
Diabetes as risk factor for pancreatic cancer: hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells.
https://doi.org/10.1016/j.canlet.2017.12.004
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Brandt S. J., Müller T. D., DiMarchi R. D., Tschöp M. H., Stemmer Kerstin.
Peptide-based multi-agonists: a new paradigm in metabolic pharmacology.
https://doi.org/10.1111/joim.12837
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2017 |
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Ryan Karen K, Packard Amy E B, Larson Karlton R, Stout Jayna, Fourman Sarah M, Thompson Abigail M K, Ludwick Kristen, Habegger Kirk M, Stemmer Kerstin, Itoh Nobuyuki, Perez-Tilve Diego, Tschöp Matthias H, Seeley Randy J, Ulrich-Lai Yvonne M.
Dietary manipulations that induce ketosis activate the HPA axis in male rats and mice: a potential role for fibroblast growth factor-21.
https://doi.org/10.1210/en.2017-00486
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Pfuhlmann Katrin, Pfluger Paul T., Schriever Sonja C., Müller Timo D., Tschöp Matthias H., Stemmer Kerstin.
Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice.
https://doi.org/10.1371/journal.pone.0183488
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Kleinert Maximilian, Clemmensen Christoffer, Stemmer Kerstin, Müller Timo D., DiMarchi Richard D., Tschöp Matthias H..
Emerging poly-agonists for obesity and Type 2 Diabetes.
https://doi.org/10.1002/oby.21932
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Giles Daniel A, Moreno-Fernandez Maria E, Stankiewicz Traci E, Graspeuntner Simon, Cappelletti Monica, Wu David, Mukherjee Rajib, Chan Calvin C, Lawson Matthew J, Klarquist Jared, Sünderhauf Annika, Softic Samir, Kahn C Ronald, Stemmer Kerstin, Iwakura Yoichiro, Aronow Bruce J, Karns Rebekah, Steinbrecher Kris A, Karp Christopher L, Sheridan Rachel, Shanmukhappa Shiva K, Reynaud Damien, Haslam David B, Sina Christian, Rupp Jan, Hogan Simon P, Divanovic Senad.
Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.
https://doi.org/10.1038/nm.4346
BibTeX | RIS | DOI Erratum: Nature Medicine 23, 1241 (2017), DOI 10.1038/nm1017-1241c |
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Klaus Valentina, Bastek Heinke, Damme Katja, Collins Leonard B., Frötschl Roland, Benda Norbert, Lutter Dominik, Ellinger-Ziegelbauer Heidrun, Swenberg James A., Dietrich Daniel R., Stemmer Kerstin.
Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats.
https://doi.org/10.1007/s00204-017-1953-6
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2016 |
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Maida Adriano, Zota Annika, Sjøberg Kim A., Schumacher Jonas, Sijmonsma Tjeerd P., Pfenninger Anja, Christensen Marie M., Gantert Thomas, Fuhrmeister Jessica, Rothermel Ulrike, Schmoll Dieter, Heikenwälder Mathias, Iovanna Juan L., Stemmer Kerstin, Kiens Bente, Herzig Stephan, Rose Adam J..
A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.
https://doi.org/10.1172/jci85946
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Finan Brian, Clemmensen Christoffer, Zhu Zhimeng, Stemmer Kerstin, Gauthier Karine, Müller Luisa, De Angelis Meri, Moreth Kristin, Neff Frauke, Perez-Tilve Diego, Fischer Katrin, Lutter Dominik, Sánchez-Garrido Miguel A., Liu Peng, Tuckermann Jan, Malehmir Mohsen, Healy Marc E., Weber Achim, Heikenwalder Mathias, Jastroch Martin, Kleinert Maximilian, Jall Sigrid, Brandt Sara, Flamant Frédéric, Schramm Karl-Werner, Biebermann Heike, Döring Yvonne, Weber Christian, Habegger Kirk M., Keuper Michaela, Gelfanov Vasily, Liu Fa, Köhrle Josef, Rozman Jan, Fuchs Helmut, Gailus-Durner Valerie, Hrabě de Angelis Martin, Hofmann Susanna M., Yang Bin, Tschöp Matthias H., DiMarchi Richard, Müller Timo D..
Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic impact for metabolic disease.
https://doi.org/10.1016/j.cell.2016.09.014
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Kabra Dhiraj G., Pfuhlmann Katrin, García-Cáceres Cristina, Schriever Sonja C., Casquero García Veronica, Kebede Adam Fiseha, Fuente-Martin Esther, Trivedi Chitrang, Heppner Kristy, Uhlenhaut N. Henriette, Legutko Beata, Kabra Uma D., Gao Yuanqing, Yi Chun-Xia, Quarta Carmelo, Clemmensen Christoffer, Finan Brian, Müller Timo D., Meyer Carola W., Paez-Pereda Marcelo, Stemmer Kerstin, Woods Stephen C., Perez-Tilve Diego, Schneider Robert, Olson Eric N., Tschöp Matthias H., Pfluger Paul T..
Hypothalamic leptin action is mediated by histone deacetylase 5.
https://doi.org/10.1038/ncomms10782
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2015 |
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Stemmer Kerstin, Zani Fabio, Habegger Kirk M., Neff Christina, Kotzbeck Petra, Bauer Michaela, Yalamanchilli Suma, Azad Ali, Lehti Maarit, Martins Paulo J. F., Müller Timo D., Pfluger Paul T., Seeley Randy J..
FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice.
https://doi.org/10.1007/s00125-015-3668-7
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Dargel Christina, Bassani-Sternberg Michal, Hasreiter Julia, Zani Fabio, Bockmann Jan-Hendrik, Thiele Frank, Bohne Felix, Wisskirchen Karin, Wilde Susanne, Sprinzl Martin F., Schendel Dolores J., Krackhardt Angela M., Uckert Wolfgang, Wohlleber Dirk, Schiemann Matthias, Stemmer Kerstin, Heikenwälder Mathias, Busch Dirk H., Richter Günther, Mann Matthias, Protzer Ulrike.
T cells engineered to express a T-cell receptor specific for glypican-3 to recognize and kill hepatoma cells in vitro and in mice.
https://doi.org/10.1053/j.gastro.2015.05.055
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2014 |
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Wolf Monika Julia, Adili Arlind, Piotrowitz Kira, Abdullah Zeinab, Boege Yannick, Stemmer Kerstin, Ringelhan Marc, Simonavicius Nicole, Egger Michèle, Wohlleber Dirk, Lorentzen Anna, Einer Claudia, Schulz Sabine, Clavel Thomas, Protzer Ulrike, Thiele Christoph, Zischka Hans, Moch Holger, Tschöp Matthias, Tumanov Alexei V., Haller Dirk, Unger Kristian, Karin Michael, Kopf Manfred, Knolle Percy, Weber Achim, Heikenwalder Mathias.
Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes.
https://doi.org/10.1016/j.ccell.2014.09.003
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Brockmann Anette, Strittmatter Tobias, May Sarah, Stemmer Kerstin, Marx Andreas, Brunner Thomas.
Structure–function relationship of thiazolide-induced apoptosis in colorectal tumor cells.
https://doi.org/10.1021/cb500209a
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Stemmer Kerstin, Kotzbeck P, Zani F, Bauer M, Neff C, Müller T D, Pfluger P T, Seeley R J, Divanovic S.
Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL/6 nude mice.
https://doi.org/10.1038/ijo.2014.187
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2013 |
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Dietrich Daniel R., von Aulock Sonja, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan.
Editorial.
https://doi.org/10.1016/j.yrtph.2013.07.001
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Dietrich Daniel R., von Aulock Sonja, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan.
Editorial.
https://doi.org/10.1016/j.fct.2013.07.005
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Habegger K. M., Stemmer Kerstin, Cheng C., Muller T. D., Heppner K. M., Ottaway N., Holland J., Hembree J. L., Smiley D., Gelfanov V., Krishna R., Arafat A. M., Konkar A., Belli S., Kapps M., Woods S. C., Hofmann S. M., D'Alessio D., Pfluger P. T., Perez-Tilve D., Seeley R. J., Konishi M., Itoh N., Kharitonenkov A., Spranger J., DiMarchi R. D., Tschop M. H..
Fibroblast growth factor 21 mediates specific glucagon actions.
https://doi.org/10.2337/db12-1116
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Bielohuby Maximilian, Sisley Stephanie, Sandoval Darleen, Herbach Nadja, Zengin Ayse, Fischereder Michael, Menhofer Dominik, Stoehr Barbara J. M., Stemmer Kerstin, Wanke Rüdiger, Tschöp Matthias H., Seeley Randy J., Bidlingmaier Martin.
Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets.
https://doi.org/10.1152/ajpendo.00208.2013
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Dietrich Daniel, von Aulock Sonja, Marquardt H. W. J., Blaauboer Bas J., Dekant Wolfgang, Kehrer James, Hengstler Jan G., Collier Abby C., Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan.
Open letter to the European commission: scientifically unfounded precaution drives European commission’s recommendations on EDC regulation, while defying common sense, well-established science, and risk assessment principles.
https://doi.org/10.1007/s00204-013-1117-2
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Stemmer Kerstin, Bielohuby Maximilian, Grayson Bernadette E., Begg Denovan P., Chambers Adam P., Neff Christina, Woods Stephen C., Erben Reinhold G., Tschöp Matthias H., Bidlingmaier Martin, Clemens Thomas L., Seeley Randy J..
Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats.
https://doi.org/10.1210/en.2012-2130
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Dietrich Daniel R., Aulock Sonja von, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan, Barile Frank A..
Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.
https://doi.org/10.1016/j.toxicon.2013.10.020
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Dietrich Daniel R., Aulock Sonja von, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Barile Frank A., Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan.
Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.
https://doi.org/10.1016/j.cbi.2013.07.001
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Dietrich Daniel R., Aulock Sonja von, Marquardt Hans, Blaauboer Bas J., Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Wallace Hayes A., Gooderham Nigel, Harvey Alan.
Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.
https://doi.org/10.1016/j.tiv.2013.07.001
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Dietrich Daniel R., von Aulock Sonja, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan.
Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.
https://doi.org/10.14573/altex.2013.3.381
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Müller Timo D., Müller Anne, Yi Chun-Xia, M Habegger Kirk, Meyer Carola W., Gaylinn Bruce D., Finan Brian, Heppner Kristy, Trivedi Chitrang, Bielohuby Maximilian, Abplanalp William, Meyer Franziska, Piechowski Carolin L., Pratzka Juliane, Stemmer Kerstin, Holland Jenna, Hembree Jazzmin, Bhardwaj Nakul, Raver Christine, Ottaway Nickki, Krishna Radha, Sah Renu, Sallee Floyd R., Woods Stephen C., Perez-Tilve Diego, Bidlingmaier Martin, Thorner Michael O., Krude Heiko, Smiley David, DiMarchi Richard, Hofmann Susanna, Pfluger Paul T., Kleinau Gunnar, Biebermann Heike, Tschöp Matthias H..
The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.
https://doi.org/10.1038/ncomms2968
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2012 |
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Stemmer Kerstin, Perez-Tilve Diego, Ananthakrishnan Gayathri, Bort Anja, Seeley Randy J., Tschöp Matthias H., Dietrich Daniel R., Pfluger Paul T..
High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney.
https://doi.org/10.1242/dmm.009407
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Okle Oliver, Stemmer Kerstin, Deschl Ulrich, Dietrich Daniel R..
L-BMAA induced ER stress and enhanced caspase 12 cleavage in human neuroblastoma SH-SY5Y cells at low nonexcitotoxic concentrations.
https://doi.org/10.1093/toxsci/kfs291
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Finan Brian, Yang Bin, Ottaway Nickki, Stemmer Kerstin, Müller Timo D, Yi Chun-Xia, Habegger Kirk, Schriever Sonja C, García-Cáceres Cristina, Kabra Dhiraj G, Hembree Jazzminn, Holland Jenna, Raver Christine, Seeley Randy J, Hans Wolfgang, Irmler Martin, Beckers Johannes, de Angelis Martin Hrabě, Tiano Joseph P, Mauvais-Jarvis Franck, Perez-Tilve Diego, Pfluger Paul, Zhang Lianshan, Gelfanov Vasily, DiMarchi Richard D, Tschöp Matthias H.
Targeted estrogen delivery reverses the metabolic syndrome.
https://doi.org/10.1038/nm.3009
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Müller Timo D., Lee Sang Jun, Jastroch Martin, Kabra Dhiraj, Stemmer Kerstin, Aichler Michaela, Abplanalp Bill, Ananthakrishnan Gayathri, Bhardwaj Nakul, Collins Sheila, Divanovic Senad, Endele Max, Finan Brian, Gao Yuanqing, Habegger Kirk M., Hembree Jazzmin, Heppner Kristy M., Hofmann Susanna, Holland Jenna, Küchler Daniela, Kutschke Maria, Krishna Radha, Lehti Maarit, Oelkrug Rebecca, Ottaway Nickki, Perez-Tilve Diego, Raver Christine, Walch Axel K., Schriever Sonja C., Speakman John, Tseng Yu-Hua, Diaz-Meco Maria, Pfluger Paul T., Moscat Jorge, Tschöp Matthias H..
p62 Links β-adrenergic input to mitochondrial function and thermogenesis.
https://doi.org/10.1172/jci64209
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2011 |
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Stemmer Kerstin, Dietrich Daniel R..
Application of laser-capture microdissection to study renal carcinogenesis.
https://doi.org/10.1007/978-1-61779-163-5_23
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Bielohuby Maximilian, Stemmer Kerstin, Berger José, Ramisch Juliane, Smith Kathleen, Holland Jenna, Parks Kenneth, Pfluger Paul T., Habegger Kirk M., Tschöp Matthias H., Seeley Randy J., Bidlingmaier Martin.
Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats.
https://doi.org/10.1007/s11695-011-0528-5
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Feurstein Daniel, Stemmer Kerstin, Kleinteich Julia, Speicher Tobias, Dietrich Daniel R.
Microcystin congener– and concentration-dependent induction of murine neuron apoptosis and neurite degeneration.
https://doi.org/10.1093/toxsci/kfr243
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2010 |
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Bielohuby Maximilian, Menhofer Dominik, Kirchner Henriette, Stoehr Barbara J. M., Müller Timo D., Stock Peggy, Hempel Madlen, Stemmer Kerstin, Pfluger Paul T., Kienzle Ellen, Christ Bruno, Tschöp Matthias H., Bidlingmaier Martin.
Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein.
https://doi.org/10.1152/ajpendo.00478.2010
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Feurstein Daniel, Kleinteich Julia, Heussner Alexandra H., Stemmer Kerstin, Dietrich Daniel R..
Investigation of microcystin congener–dependent uptake into primary murine neurons.
https://doi.org/10.1289/ehp.0901289
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Fischer A., Hoeger S.J., Stemmer Kerstin, Feurstein D.J., Knobeloch D., Nussler A., Dietrich D.R..
The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: a comparison of primary human hepatocytes and OATP-transfected HEK293 cells.
https://doi.org/10.1016/j.taap.2010.02.006
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2009 |
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Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Ahr Hans-Jürgen, Dietrich Daniel R..
Molecular characterization of preneoplastic lesions provides insight on the development of renal tumors.
https://doi.org/10.2353/ajpath.2009.081071
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2007 |
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Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Ahr Hans-Juergen, Dietrich Daniel R..
Carcinogen-specific gene expression profiles in short-term treated eker and wild-type rats indicative of pathways involved in renal tumorigenesis.
https://doi.org/10.1158/0008-5472.can-06-3587
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2006 |
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Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Lotz Kerstin, Ahr Hans-J., Dietrich Daniel R..
Establishment of a protocol for the gene expression analysis of laser microdissected rat kidney samples with affymetrix genechips.
https://doi.org/10.1016/j.taap.2006.07.012
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