Forschung - Vaskuläre Biologie (Meissner)

Forschungsprojekte

Forschungsschwerpunkte

Als Physiologen befassen wir uns mit den Funktionen des Lebens vom Molekül bis zum Organismus. In unseren Forschungsprojekten beschäftigen wir uns hierbei vor allem mit der Funktionsfähigkeit des Herz-Kreislauf-Systems.

Die meisten Herzkreislauferkrankungen beeinträchtigen häufig auch die Gesundheit verschiedener wichtiger Organe wie Lunge, Gehirn oder Nieren. Die Behandlungen dieser Organschäden sind oft kompliziert. In unserer Forschung nehmen wir biologisch wichtige Signalmoleküle in den Blick, die eine Rolle bei der Regulierung des Herzkreislauf- und Immunsystems spielen. Durch unsere Forschung in diesem Bereich hoffen wir, Ansatzpunkte für neue Behandlungsmöglichkeiten identifizieren zu können.

Forschungsprojekte

Forschungsmethoden

Modellierung kardiovaskulärer Erkrankungen (z.B. Herzinsuffzienz, Schlaganfall, Hypertonie)
Nicht-invasive Bildgebung (Magnetresonanztomographie) zur Bestimmung von Herzfunktion, Hirnperfusion, Infarktgröße
Verhaltensuntersuchungen zum Erfassen kognitiver Beeinträchtigungen bei Herz-Kreislauferkrankungen
Immunoprofiling mittels Durchflusszytometrie
Anwendung histologische Methoden zur Erfassung struktureller Zell- und Gewebsveränderungen sowie Expressionsmusterveränderungen
Anwendung mikroskopischer Techniken wie Fluoresenzmikroskopie, Konfokalmikroskopie
Verwendung zellbiologischer, biochemischer und molekularbiologischer Methoden, darunter genetische Modifikationen von Zellen, Polymerase-Kettenreaktionen (PCR), Western Blot, Enzyme-linked Immunsorbent Assay (ELISA).
Biomarker-Validierung in klinischen Proben
Anwendung verschiedener in vitro und ex vivo Methoden zur funktionellen Untersuchung von Zell-Zell-Interaktionen
Massenspektrometrie zur Bestimmung von Sphingosine-1-phosphat Konzentrationen in Blut und Gewebe

Team Vaskuläre Biologie

Publikationen

Kollaborationen

Prof. Janina Bahnemann, Technische Biologie, Universität Augsburg
Prof. Christoph Knote, Model-based Environmental Exposure Science, Universität Augsburg
Prof. Arne Lindgren, Neurologie – Stroke Unit, Universitätsklinikum Lund, Schweden
Dr. Martin Magnusson, Kardiologie, Universitätsklinikum Lund (Malmö), Schweden
Dr. Iben Lundgaard, Glymphatic System, Lund Universität, Schweden
Dr. Joao Duarte, Diabetes and Brain Function, Lund Universität, Schweden
Prof. Lena Uller, Airway Inflammation, Lund Universität, Schweden
Prof. Gabor Petzold, Deutsches Zentrum für Neurodegenerative Erkrankungen Bonn
Prof. Jörg Fritz, McGill University, Montreal, Kanada
Prof. Steffen-Sebastian Bolz, Department of Physiology, University of Toronto, Kanada

Meissner Anja, Liefke Jonas, Matthes Frank, Morsing Eva, Ley David, Hedström Erik. Plasma biomarkers of inflammation associate with blood pressure and arterial stiffness in adolescents after very preterm birth. Cardiovascular Research 2024;cvae192. https://doi.org/10.1093/cvr/cvae192
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Matuskova Hana, Porschen Lisa T., Matthes Frank, Lindgren Arne G., Petzold Gabor C., Meissner Anja. Spatiotemporal sphingosine-1-phosphate receptor 3 expression within the cerebral vasculature after ischemic stroke. iScience 2024;110031. https://doi.org/10.1016/j.isci.2024.110031
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Vanherle Lotte, Lidington Darcy, Uhl Franziska E., Steiner Saskia, Vassallo Stefania, Skoug Cecilia, Duarte Joao M. N., Ramu Sangeetha, Uller Lena, Desjardins Jean-François, Connelly Kim A., Bolz Steffen-Sebastian, Meissner Anja. Restoring myocardial infarction-induced long-term memory impairment by targeting the cystic fibrosis transmembrane regulator. eBioMedicine 2022;86:104384. https://doi.org/10.1016/j.ebiom.2022.104384
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Jujic Amra, Vieira João P. P., Matuskova Hana, Nilsson Peter M., Lindblad Ulf, Olsen Michael H., Duarte João M. N., Meissner Anja, Magnusson Martin. Plasma galectin-4 levels are increased after stroke in mice and humans. International Journal of Molecular Sciences 2023;24(12):10064. https://doi.org/10.3390/ijms241210064
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Battistella Roberta, Kritsilis Marios, Matuskova Hana, Haswell Douglas, Cheng Anne Xiaoan, Meissner Anja, Nedergaard Maiken, Lundgaard Iben. Not all lectins are equally suitable for labeling rodent vasculature. International Journal of Molecular Sciences 2021;22(21):11554. https://doi.org/10.3390/ijms222111554
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Matthes Frank, Matuskova Hana, Arkelius Kajsa, Ansar Saema, Lundgaard Iben, Meissner Anja. An improved method for physical separation of cerebral vasculature and parenchyma enables detection of blood-brain-barrier dysfunction. NeuroSci 2021;2(1):59-74. https://doi.org/10.3390/neurosci2010004
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Lidington Darcy, Fares Jessica C., Uhl Franziska E., Dinh Danny D., Kroetsch Jeffrey T., Sauvé Meghan, Malik Firhan A., Matthes Frank, Vanherle Lotte, Adel Arman, Momen Abdul, Zhang Hangjun, Aschar-Sobbi Roozbeh, Foltz Warren D., Wan Hoyee, Sumiyoshi Manabu, Macdonald R. Loch, Husain Mansoor, Backx Peter H., Heximer Scott P., Meissner Anja, Bolz Steffen-Sebastian. CFTR therapeutics normalize cerebral perfusion deficits in mouse models of heart failure and subarachnoid hemorrhage. JACC: Basic to Translational Science 2019;4(8):940-958. https://doi.org/10.1016/j.jacbts.2019.07.004
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Munk Anne Sofie, Wang Wei, Bèchet Nicholas Burdon, Eltanahy Ahmed M., Cheng Anne Xiaoan, Sigurdsson Björn, Benraiss Abdellatif, Mäe Maarja A., Kress Benjamin Travis, Kelley Douglas H., Betsholtz Christer, Møllgård Kjeld, Meissner Anja, Nedergaard Maiken, Lundgaard Iben. PDGF-B is required for development of the glymphatic system. Cell Reports 2019;26(11):2955-2969.e3. https://doi.org/10.1016/j.celrep.2019.02.050
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Meissner Anja, Garcia-Serrano Alba M., Vanherle Lotte, Rafiee Zeinab, Don-Doncow Nicholas, Skoug Cecilia, Larsson Sara, Gottschalk Michael, Magnusson Martin, Duarte João M. N.. Alterations to cerebral perfusion, metabolite profiles, and neuronal morphology in the hippocampus and cortex of male and female mice during chronic exposure to a high-salt diet. International Journal of Molecular Sciences 2023;24(1):300. https://doi.org/10.3390/ijms24010300
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Jujic Amra, Matthes Frank, Vanherle Lotte, Petzka Henning, Orho-Melander Marju, Nilsson Peter M., Magnusson Martin, Meissner Anja. Plasma S1P (Sphingosine-1-Phosphate) links to hypertension and biomarkers of inflammation and cardiovascular disease: findings from a translational investigation. Hypertension 2021;78(1):195-209. https://doi.org/10.1161/hypertensionaha.120.17379
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Forschungsförderung

Intramurale Forschungsförderung

„Forschungspotenziale besser nutzen!“, Universität Augsburg – Förderung seit 2024

Förderung Tandemprojekt, Medizinische Fakultät, Universität Augsburg – Förderung seit 2024

Drittmittel

Hjärnfonden: Cell-specific S1P signaling alterations mediate neurovascular unit impairment in response to ischemia – Förderzeitraum 2024 – 2025

Albert Påhlsson Stiftelse Projektförderung: Sex-specific cardiovascular consequences of high in dietary salt consumption – Förderzeitraum 2022 – 2025

Wenner Gren Stiftelse Projektförderung: Immunomodulation in hypertension improves outcome after myocardial infarction – Förderzeitraum 2022 – 2024

Crafoordska Stiftelse Projektförderung: The role of ischemia-induced S1P-S1pr3 signaling in astrocytes – Förderzeitraum 2022 – 2024

Vetenskapsrådet Projektförderung: Inkretinsystemets inverkan på hjärt-kärlsjukdom och cancer – Förderzeitraum 2023 – 2026

DFG Projektförderung: Hypertension-related cognitive deficits and sphingosine-1-phosphate (S1P) - pathophysiology and therapeutic significance – Förderzeitraum 2017 – 2021

Vetenskapsrådet Projektförderung: Communication between Sphingosine-1-phosphate signaling and the Renin-Angiotensin System during hypertension: a bearer of therapeutic significance in blood pressure regulation and Target Organ Damage? – Förderzeitraum 2018 – 2020

Aktuelles

Elucidating mechanistic pathways of ambient particulate matter pollution on the cerebral vasculature

Dr. Frank Matthes (Vaskuläre Biologie) & Dr. Katrin Gohlsch (Model-based Environmental Exposure Science) erhalten Projektförderung, um gemeinsam den Einfluss von Luftverschmutzung auf die Blutgefäße des Gehirns zu untersuchen

Investigating the Cause and Focusing on Treating Heart Failure-Related Target Organ Damage

Lotte Vanherle verteidigt ihre Doktorarbeit. Faculty Opponent: Prof. Chris Sobey Latrobe University, Melbourne, Australien PhD committee members: Prof. Angela Censi-Nilsson (Lund Universität, Schweden) Dr. Darcy Wagner (Lund Universität, Schweden) Dr. Emma Börgesson (Aarhus University, Dänemark)

10. April 2024

Poster Prize WCMM Research Day 2024

Congrats to Lisa Porschen for winning this year's WCMM Research Day Poster prize! Poster Title: "High fat diet and its effects on altered S1P signaling in experimental stroke"

31. Mai 2024

PhD convocation ceremony

The official convocation ceremony of Lund University took place today with the latest PhD graduate of the Vascular Biology Research Group.

31. Mai 2024

New publication on S1P signaling in stroke

In our recent publication, we show that the S1P receptor S1PR3 is acutely upregulated in perilesional reactive astrocytes after ischemic stroke and that stroke volume and behavioral deficits are ameliorated in mice lacking S1PR3. Importantly, administration of an S1PR3 antagonist at 4 hours post-stroke, but not at later time points, improves stroke outcome. Finally, we observed higher plasma S1PR3 levels in experimental stroke and in patients with ischemic stroke. Taken together, our results establish S1PR3 as a potential drug target and biomarker in ischemic stroke. Read all details here: Matuskova et al., iScience 27, 110031 June 21, 2024: https://doi.org/10.1016/ j.isci.2024.110031

7. Juni 2024

Vascular Biology Post-doc Fatima Gimeno-Ferrer receives prize for best doctoral thesis!

Fatima graduated with distinctions (summa cum laude) on the "Impact of neuroinflammation and neurodegeneration on brain homeostasis" at the Faculty of Medicine, Friedrich-Schiller-University Jena in December 2023. In May, 2024 Fatima was awarded with the prize for the best PhD thesis. Congratulations on a well-deserved award, Fatima!

Stellenangebote

Sie sind eine ambitionierte Wissenschaftlerin oder ein ambitionierter Wissenschaftler und interessieren sich für kardiovaskuläre Grundlagenforschung?

Unser Team arbeitet an anspruchsvollen und vielseitigen Forschungsprojekten mit modernsten Methoden in einer inspirierenden, internationalen Atmosphäre.

Wir sind immer interessiert, mit motivierten Studentinnen und Studenten im Rahmen von Praktika, Bachelor- und Masterarbeiten sowie medizinischen Promotionen zusammenzuarbeiten. Sprechen Sie uns einfach an!

Publikationen

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2005

2024

Gimeno-Ferrer Fátima, Eitner Annett, Schaible Hans-Georg, Richter Frank. Galanin diminishes cortical spreading depolarization across rodents – a candidate for treatment?. Neuroscience Letters 2024;832:137814. https://doi.org/10.1016/j.neulet.2024.137814
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2023

Meyer Katharina V., Winkler Steffen, Lienig Pascal, Dräger Gerald, Bahnemann Janina. 3D-printed microfluidic perfusion system for parallel monitoring of hydrogel-embedded cell cultures. Cells 2023;12(14):1816. https://doi.org/10.3390/cells12141816
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Malm Tillgren Sofia, Nieto-Fontarigo Juan José, Cerps Samuel, Ramu Sangeetha, Menzel Mandy, Mahmutovic Persson Irma, Meissner Anja, Akbarshahi Hamid, Uller Lena. C57Bl/6N mice have an attenuated lung inflammatory response to dsRNA compared to C57Bl/6J and BALB/c mice. Journal of Inflammation 2023;20(1):6. https://doi.org/10.1186/s12950-023-00331-4
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Skoug Cecilia, Erdogan Hüseyin, Vanherle Lotte, Vieira João P. P., Matthes Frank, Eliasson Lena, Meissner Anja, Duarte João M. N.. Density of sphingosine-1-phosphate receptors is altered in cortical nerve-terminals of insulin-resistant Goto-Kakizaki rats and diet-induced obese mice. Neurochemical Research 2023;49:338-347. https://doi.org/10.1007/s11064-023-04033-4
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Wohlenberg Ole Jacob, Kortmann Carlotta, Meyer Katharina V., Scheper Thomas, Solle Dörte. Employing QbD strategies to assess the impact of cell viability and density on the primary recovery of monoclonal antibodies. Engineering in Life Sciences 2023;23(2):e202200056. https://doi.org/10.1002/elsc.202200056
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Porschen Lisa, Matuskova Hana, Matthes Frank, Meissner Anja. High-fat diet and its effects on altered S1P signaling after stroke [Abstract]. Journal of Neurochemistry 2023;166(S1):102. https://doi.org/10.1111/jnc.15897
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Sahoglu Sevilay Goktas, Kazci Yusuf Enes, Karadogan Behnaz, Aydin Mehmet Serif, Nebol Aylin, Turhan Mehmet Ugurcan, Ozturk Gurkan, Cagavi Esra. High‐resolution mapping of sensory fibers at the healthy and post‐myocardial infarct whole transgenic hearts. Journal of Neuroscience Research 2023;101(3):338-353. https://doi.org/10.1002/jnr.25150
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Vanherle Lotte, Matthes Frank, Uhl Franziska E., Meissner Anja. Ivacaftor therapy post myocardial infarction augments systemic inflammation and evokes contrasting effects with respect to tissue inflammation in brain and lung. Biomedicine & Pharmacotherapy 2023;162:114628. https://doi.org/10.1016/j.biopha.2023.114628
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Lau Kristina, Porschen Lisa T., Richter Franziska, Gericke Birthe. Microvascular blood-brain barrier alterations in isolated brain capillaries of mice over-expressing alpha-synuclein (Thy1-aSyn line 61). Neurobiology of Disease 2023;187:106298. https://doi.org/10.1016/j.nbd.2023.106298
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Goktas Sevilay Sahoglu, Vanherle Lotte, Rafiee Zeinab, Duarte Joao, Meissner Anja. Sex-specific cardiovascular responses to long-term high-salt diet [Abstract]. Journal of Vascular Research 2023;60(Supplement 1):30-31. https://doi.org/10.1159/000533846
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Vanherle Lotte, Corrigan Alex, Vassallo Stefania, Meissner Anja. Spatiotemporal profile of myocardial infarction-induced brain alterations [Abstract]. Journal of Neurochemistry 2023;166(S1):98. https://doi.org/10.1111/jnc.15897
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Matuskova Hana, Matthes Frank, Petzold Gabor, Meissner Anja. Sphingosine-1-phosphate receptor 3 signaling is a critical modulator of stroke outcome [Abstract]. Journal of Vascular Research 2023;60(Supplement 1):19. https://doi.org/10.1159/000533846
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Vanherle Lotte, Matthes Frank, Meissner Anja. Targeting sphingosine-1-phosphate signaling in hypertension - a new treatment opportunity [Abstract]. Journal of Vascular Research 2023;60(Supplement 1):16-17. https://doi.org/10.1159/000533846
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Edsfeldt Andreas, Singh Pratibha, Matthes Frank, Tengryd Christoffer, Cavalera Michele, Bengtsson Eva, Dunér Pontus, Volkov Petr, Karadimou Glykeria, Gisterå Anton, Orho-Melander Marju, Nilsson Jan, Sun Jiangming, Gonçalves Isabel. Transforming growth factor-β2 is associated with atherosclerotic plaque stability and lower risk for cardiovascular events. Cardiovascular Research 2023;119(11):2061-2073. https://doi.org/10.1093/cvr/cvad079
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2022

Winkler Steffen, Menke Jannik, Meyer Katharina V., Kortmann Carlotta, Bahnemann Janina. Automation of cell culture assays using a 3D-printed servomotor-controlled microfluidic valve system. Lab on a Chip 2022;22(23):4656-4665. https://doi.org/10.1039/d2lc00629d
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Uhl Franziska E., Vanherle Lotte, Meissner Anja. Cystic fibrosis transmembrane regulator correction attenuates heart failure-induced lung inflammation. Frontiers in Immunology 2022;13:928300. https://doi.org/10.3389/fimmu.2022.928300
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Winkler Steffen, Meyer Katharina V., Heuer Christopher, Kortmann Carlotta, Dehne Michaela, Bahnemann Janina. In vitro biocompatibility evaluation of a heat‐resistant 3D printing material for use in customized cell culture devices. Engineering in Life Sciences 2022;22(11):699-708. https://doi.org/10.1002/elsc.202100104
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Al-Sharify Dania, Nielsen Signe Holm, Matthes Frank, Tengryd Christoffer, Sun Jiangming, Genovese Federica, Karsdal Morten A., Nilsson Jan, Goncalves Isabel, Edsfeldt Andreas. Increased proteolytic cleavage of osteoglycin is associated with a stable plaque phenotype and lower risk of cardiovascular events. Atherosclerosis 2022;355:8-14. https://doi.org/10.1016/j.atherosclerosis.2022.06.1025
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Wohlenberg Ole Jacob, Kortmann Carlotta, Meyer Katharina V., Schellenberg Jana, Dahlmann Katharina, Bahnemann Janina, Scheper Thomas, Solle Dörte. Optimization of a mAb production process with regard to robustness and product quality using quality by design principles. Engineering in Life Sciences 2022;22(7):484-494. https://doi.org/10.1002/elsc.202100172
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Gonçalves Isabel, Oduor Loureen, Matthes Frank, Rakem Narjess, Meryn Jakob, Skenteris Nikolaos-Taxiarchis, Aspberg Anders, Orho-Melander Marju, Nilsson Jan, Matic Ljubica, Edsfeldt Andreas, Sun Jiangming, Bengtsson Eva. Osteomodulin gene expression is associated with plaque calcification, stability, and fewer cardiovascular events in the CPIP cohort. Stroke 2022;53(3):e79-e84. https://doi.org/10.1161/strokeaha.121.037223
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Skoug Cecilia, Martinsson Isak, Gouras Gunnar K., Meissner Anja, Duarte João M. N.. Sphingosine 1-phoshpate receptors are located in synapses and control spontaneous activity of mouse neurons in culture. Neurochemical Research 2022;47(10):3114-3125. https://doi.org/10.1007/s11064-022-03664-3
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Uhl Franziska E., Vanherle Lotte, Matthes Frank, Meissner Anja. Therapeutic CFTR correction normalizes systemic and lung-specific S1P level alterations associated with heart failure. International Journal of Molecular Sciences 2022;23(2):866. https://doi.org/10.3390/ijms23020866
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2021

Meyer Katharina V., Siller Ina G., Schellenberg Jana, Gonzalez Salcedo Alina, Solle Dörte, Matuszczyk Jens, Scheper Thomas, Bahnemann Janina. Monitoring cell productivity for the production of recombinant proteins by flow cytometry: an effective application using the cold capture assay. Engineering in Life Sciences 2021;21(5):288-293. https://doi.org/10.1002/elsc.202000049
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Don-Doncow Nicholas, Vanherle Lotte, Matthes Frank, Petersen Sine Kragh, Matuskova Hana, Rattik Sara, Härtlova Anetta, Meissner Anja. Simvastatin therapy attenuates memory deficits that associate with brain monocyte infiltration in chronic hypercholesterolemia. npj Aging and Mechanisms of Disease 2021;7(1):19. https://doi.org/10.1038/s41514-021-00071-w
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2020

Kaminski Debora, Yaghootfam Claudia, Matthes Frank, Reßing Annika, Gieselmann Volkmar, Matzner Ulrich. Brain cell type-specific endocytosis of arylsulfatase A identifies limitations of enzyme-based therapies for metachromatic leukodystrophy. Human Molecular Genetics 2020;29(23):3807-3817. https://doi.org/10.1093/hmg/ddaa277
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Vanherle Lotte, Matuskova Hana, Don-Doncow Nicholas, Uhl Franziska E., Meissner Anja. Improving cerebrovascular function to increase neuronal recovery in neurodegeneration associated to cardiovascular disease. Frontiers in Cell and Developmental Biology 2020;8:53. https://doi.org/10.3389/fcell.2020.00053
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Vanherle Lotte, Uhl Franziska Elisabeth, Matthes Frank, Meissner Anja. Targeting cerebrovascular sphingosine‐1‐phosphate signaling to treat heart failure‐induced brain dysfunction. The FASEB Journal 2020;34(S1):1. https://doi.org/10.1096/fasebj.2020.34.s1.05599
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Don-Doncow Nicholas, Vanherle Lotte, Matthes Frank, Petzka Henning, Meissner Anja. Therapeutic inhibition of sphingosine kinase SphK2 lowers blood pressure levels in an experimental model of hypertension by reducing CD4+ T‐cell responses. The FASEB Journal 2020;34(S1):1. https://doi.org/10.1096/fasebj.2020.34.s1.04663
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2019

Graupner Nina, Prambauer Martina, Fröhlking Thorben, Graf Christopher, Becker Jonas M., Meyer Katharina, Weber David E., Weddig Nicolai B., Wunsch Timo, Burgstaller Christoph, Müssig Jörg. Copy paper as a source of reinforcement for biodegradable composites – influence of fibre loading, processing method and layer arrangement – an overview. Composites Part A: Applied Science and Manufacturing 2019;120:161-171. https://doi.org/10.1016/j.compositesa.2019.02.016
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Salas-Perdomo Angélica, Miró-Mur Francesc, Gallizioli Mattia, Brait Vanessa H., Justicia Carles, Meissner Anja, Urra Xabier, Chamorro Angel, Planas Anna M.. Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke. Scientific Reports 2019;9(1):8309. https://doi.org/10.1038/s41598-019-44845-5
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Don-Doncow Nicholas, Vanherle Lotte, Zhang Yun, Meissner Anja. T-Cell accumulation in the hypertensive brain: a role for sphingosine-1-phosphate-mediated chemotaxis. International Journal of Molecular Sciences 2019;20(3):537. https://doi.org/10.3390/ijms20030537
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2018

Don-Doncow Nicholas, Zhang Yun, Rattik Sara, Björkbacka Harry, Meissner Anja. Anti-inflammatory properties of simvastatin mediate improvement of memory function in aged ApoE-/- Mice. Atherosclerosis Supplements 2018;32:98. https://doi.org/10.1016/j.atherosclerosissup.2018.04.298
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Matthes Frank, Hettich Moritz M., Schilling Judith, Flores-Dominguez Diana, Blank Nelli, Wiglenda Thomas, Buntru Alexander, Wolf Hanna, Weber Stephanie, Vorberg Ina, Dagane Alina, Dittmar Gunnar, Wanker Erich, Ehninger Dan, Krauss Sybille. Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis. Cell Death Discovery 2018;4(1):4. https://doi.org/10.1038/s41420-017-0003-8
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Unterbruner Kristoffer, Matthes Frank, Schilling Judith, Nalavade Rohit, Weber Stephanie, Winter Jennifer, Krauß Sybille. MicroRNAs miR-19, miR-340, miR-374 and miR-542 regulate MID1 protein expression. PLoS ONE 2018;13(1):e0190437. https://doi.org/10.1371/journal.pone.0190437
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Matthes Frank, Massari Serena, Bochicchio Anna, Schorpp Kenji, Schilling Judith, Weber Stephanie, Offermann Nina, Desantis Jenny, Wanker Erich, Carloni Paolo, Hadian Kamyar, Tabarrini Oriana, Rossetti Giulia, Krauss Sybille. Reducing mutant Huntingtin protein expression in living cells by a newly identified RNA CAG binder. ACS Chemical Neuroscience 2018;9(6):1399-1408. https://doi.org/10.1021/acschemneuro.8b00027
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Don‐Doncow Nicholas, Zhang Yun, Matuskova Hana, Meissner Anja. The emerging alliance of sphingosine‐1‐phosphate signalling and immune cells: from basic mechanisms to implications in hypertension. British Journal of Pharmacology 2018;176(12):1989-2001. https://doi.org/10.1111/bph.14381
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Evert Bernd O., Nalavade Rohit, Jungverdorben Johannes, Matthes Frank, Weber Stephanie, Rajput Ashish, Bonn Stefan, Brüstle Oliver, Peitz Michael, Krauß Sybille. Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3. PLoS ONE 2018;13(8):e0201794. https://doi.org/10.1371/journal.pone.0201794
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2017

Ercan Ebru, Eid Sameh, Weber Christian, Kowalski Alexandra, Bichmann Maria, Behrendt Annika, Matthes Frank, Krauss Sybille, Reinhardt Peter, Fulle Simone, Ehrnhoefer Dagmar E.. A validated antibody panel for the characterization of tau post-translational modifications. Molecular Neurodegeneration 2017;12(1):87. https://doi.org/10.1186/s13024-017-0229-1
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Schweiger Susann, Matthes Frank, Posey Karen, Kickstein Eva, Weber Stephanie, Hettich Moritz M., Pfurtscheller Sandra, Ehninger Dan, Schneider Rainer, Krauß Sybille. Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex. Scientific Reports 2017;7(1):13753. https://doi.org/10.1038/s41598-017-12974-4
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Meissner Anja. S1PR (Sphingosine-1-Phosphate Receptor) signaling in the regulation of vascular tone and blood pressure: is S1PR1 doing the trick?. Hypertension 2017;70(2):232-234. https://doi.org/10.1161/hypertensionaha.117.09200
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Meissner Anja, Miro Francesc, Jiménez-Altayó Francesc, Jurado Andrés, Vila Elisabet, Planas Anna M.. Sphingosine-1-phosphate signalling—a key player in the pathogenesis of Angiotensin II-induced hypertension. Cardiovascular Research 2017;113(2):123-133. https://doi.org/10.1093/cvr/cvw256
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2016

Meissner Anja. Hypertension and the brain: a risk factor for more than heart disease. Cerebrovascular Diseases 2016;42(3-4):255-262. https://doi.org/10.1159/000446082
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Griesche Nadine, Schilling Judith, Weber Stephanie, Rohm Marlena, Pesch Verena, Matthes Frank, Auburger Georg, Krauss Sybille. Regulation of mRNA translation by MID1: a common mechanism of expanded CAG repeat RNAs. Frontiers in Cellular Neuroscience 2016;10:226. https://doi.org/10.3389/fncel.2016.00226
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Meissner Anja, Minnerup Jens, Soria Guadalupe, Planas Anna M. Structural and functional brain alterations in a murine model of Angiotensin II-induced hypertension. Journal of Neurochemistry 2016;140(3):509-521. https://doi.org/10.1111/jnc.13905
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2015

Matthes Frank, Andersson Claes, Stein Axel, Eistrup Carl, Fogh Jens, Gieselmann Volkmar, Wenger David A., Matzner Ulrich. Enzyme replacement therapy of a novel humanized mouse model of globoid cell leukodystrophy. Experimental Neurology 2015;271:36-45. https://doi.org/10.1016/j.expneurol.2015.04.020
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Malik Firhan A., Meissner Anja, Semenkov Illya, Molinski Steven, Pasyk Stan, Ahmadi Saumel, Bui Hai H., Bear Christine E., Lidington Darcy, Bolz Steffen-Sebastian. Sphingosine-1-Phosphate is a novel regulator of cystic fibrosis transmembrane conductance regulator (CFTR) activity. PLOS ONE 2015;10(6):e0130313. https://doi.org/10.1371/journal.pone.0130313
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Yagi Kenji, Lidington Darcy, Wan Hoyee, Fares Jessica C., Meissner Anja, Sumiyoshi Manabu, Ai Jinglu, Foltz Warren D., Nedospasov Sergei A., Offermanns Stefan, Nagahiro Shinji, Macdonald R. Loch, Bolz Steffen-Sebastian. Therapeutically targeting tumor necrosis factor-α/Sphingosine-1-Phosphate signaling corrects myogenic reactivity in subarachnoid hemorrhage. Stroke 2015;46(8):2260-2270. https://doi.org/10.1161/strokeaha.114.006365
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Meissner Anja, Visanji Naomi P., Momen M. Abdul, Feng Rui, Francis Beverly M., Bolz Steffen‐Sebastian, Hazrati Lili‐Naz. Tumor necrosis factor‐α underlies loss of cortical dendritic spine density in a mouse model of congestive heart failure. Journal of the American Heart Association 2015;4(5). https://doi.org/10.1161/jaha.115.001920
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2014

Schweiger Susann, Dorn Stephanie, Fuchs Melanie, Köhler Andrea, Matthes Frank, Müller Eva-Christina, Wanker Erich, Schneider Rainer, Krauß Sybille. The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu. Journal of Biological Chemistry 2014;289(46):31805-31817. https://doi.org/10.1074/jbc.m113.541219
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Hettich Moritz M., Matthes Frank, Ryan Devon P., Griesche Nadine, Schröder Susanne, Dorn Stephanie, Krauß Sybille, Ehninger Dan. The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex. PLoS ONE 2014;9(7):e102420. https://doi.org/10.1371/journal.pone.0102420
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2012

Matthes Frank, Stroobants S., Gerlach D., Wohlenberg C., Wessig C., Fogh J., Gieselmann V., Eckhardt M., D'Hooge R., Matzner U.. Efficacy of enzyme replacement therapy in an aggravated mouse model of metachromatic leukodystrophy declines with age. Human Molecular Genetics 2012;21(11):2599-2609. https://doi.org/10.1093/hmg/dds086
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Yang Jingli, Hossein Noyan-Ashraf M., Meissner Anja, Voigtlaender-Bolz Julia, Kroetsch Jeffrey T., Foltz Warren, Jaffray David, Kapoor Amita, Momen Abdul, Heximer Scott P., Zhang Hangjun, van Eede Matthijs, Henkelman R. Mark, Matthews Stephen G., Lidington Darcy, Husain Mansoor, Bolz Steffen-Sebastian. Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α–dependent activation of Sphingosine-1-Phosphate signaling. Circulation 2012;126(2):196-206. https://doi.org/10.1161/circulationaha.111.039644
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Meissner Anja, Yang Jingli, Kroetsch Jeffrey T., Sauvé Meghan, Dax Hendrik, Momen Abdul, Noyan-Ashraf M. Hossein, Heximer Scott, Husain Mansoor, Lidington Darcy, Bolz Steffen-Sebastian. Tumor necrosis factor-α–mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological Sphingosine-1-Phosphate signaling in a mouse model of heart failure. Circulation 2012;125(22):2739-2750. https://doi.org/10.1161/circulationaha.111.047316
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2011

Stroobants S., Gerlach D., Matthes Frank, Hartmann D., Fogh J., Gieselmann V., D'Hooge R., Matzner U.. Intracerebroventricular enzyme infusion corrects central nervous system pathology and dysfunction in a mouse model of metachromatic leukodystrophy. Human Molecular Genetics 2011;20(14):2760-2769. https://doi.org/10.1093/hmg/ddr175
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Meissner Anja, Bolz Steffen‐Sebastian. TNFα affects sphingosine‐1‐phosphate signaling through modulating the expression of the cystic fibrosis transmembrane regulator (CFTR) in vascular smooth muscle cells. The FASEB Journal 2011;25(S1):1026.36. https://doi.org/10.1096/fasebj.25.1_supplement.1026.36
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Kroetsch Jeffrey Thomas, Meissner Anja, Momen Abdul, Husain Mansoor, Bolz Steffen‐Sebastian. TNFα is central to the augmented myogenic response of skeletal muscle resistance arteries in heart failure. The FASEB Journal 2011;25(S1):1026.12. https://doi.org/10.1096/fasebj.25.1_supplement.1026.12
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Matthes Frank, Wölte Philipp, Böckenhoff Annika, Hüwel Sabine, Schulz Mareike, Hyden Pia, Fogh Jens, Gieselmann Volkmar, Galla Hans-Joachim, Matzner Ulrich. Transport of arylsulfatase A across the blood-brain barrier in vitro. Journal of Biological Chemistry 2011;286(20):17487-17494. https://doi.org/10.1074/jbc.m110.189381
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2010

Lidington Darcy, Peter Bernhard Friedrich, Meissner Anja, Kroetsch Jeff, Pitson Stuart, Pohl Ulrich, Bolz Steffen‐Sebastian. Serine 225 phosphorylation governs the localization and function of sphingosine kinase 1 in resistance arteries. The FASEB Journal 2010;24(S1). https://doi.org/10.1096/fasebj.24.1_supplement.777.3
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Schröder Stephan, Matthes Frank, Hyden Pia, Andersson Claes, Fogh Jens, Müller-Loennies Sven, Braulke Thomas, Gieselmann Volkmar, Matzner Ulrich. Site-specific analysis of N-linked oligosaccharides of recombinant lysosomal arylsulfatase A produced in different cell lines. Glycobiology 2010;20(2):248-259. https://doi.org/10.1093/glycob/cwp171
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Malik F. A., Bolz S. S., Meissner Anja, Bear C. E.. Sphingosine-1-Phosphate (S1P) acutely modulates the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) protein in an AMPK-dependent manner. The Canadian Journal of Cardiology 2010;26:33D.
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Hoefer Judith, Azam M. Ali, Kroetsch Jeffrey T.E., Leong-Poi Howard, Momen M. Abdul, Voigtlaender-Bolz Julia, Scherer Elias Q., Meissner Anja, Bolz Steffen-Sebastian, Husain Mansoor. Sphingosine-1-Phosphate–dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction. Circulation Research 2010;107(7):923-933. https://doi.org/10.1161/circresaha.110.226464
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Malik Firhan Atir, Meissner Anja, Bear Christine, Bolz Steffen Sebastian. Sphingosine‐1‐Phosphate acutely modulates the CFTR (Cystic Fibrosis Transmembrane Regulator) transporter in an AMPK‐dependent manner. The FASEB Journal 2010;24(S1):609.1. https://doi.org/10.1096/fasebj.24.1_supplement.609.1
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2009

Lidington Darcy, Peter Bernhard Friedrich, Meissner Anja, Kroetsch Jeffrey T., Pitson Stuart M., Pohl Ulrich, Bolz Steffen-Sebastian. The phosphorylation motif at serine 225 governs the localization and function of sphingosine kinase 1 in resistance arteries. Arteriosclerosis, Thrombosis, and Vascular Biology 2009;29(11):1916-1922. https://doi.org/10.1161/atvbaha.109.194803
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2008

Ammermann Ingo, Bruckner Markus, Matthes Frank, Iftner Thomas, Stubenrauch Frank. Inhibition of transcription and DNA replication by the papillomavirus E8⁁E2C protein is mediated by interaction with corepressor molecules. Journal of Virology 2008;82(11):5127-5136. https://doi.org/10.1128/jvi.02647-07
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Matzner Ulrich, Matthes Frank, Weigelt Cecilia, Andersson Claes, Eistrup Carl, Fogh Jens, Gieselmann Volkmar. Non-inhibitory antibodies impede lysosomal storage reduction during enzyme replacement therapy of a lysosomal storage disease. Journal of Molecular Medicine 2008;86(4):433-442. https://doi.org/10.1007/s00109-008-0309-3
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Meissner Anja, Noack Thomas. Proliferation of human lens epithelial cells (HLE-B3) is inhibited by blocking of voltage-gated calcium channels. Pflügers Archiv - European Journal of Physiology 2008;457(1):47-59. https://doi.org/10.1007/s00424-008-0514-5
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2007

Matzner Ulrich, Matthes Frank, Herbst Eva, Lüllmann-Rauch Renate, Callaerts-Vegh Zsuzsanna, D’Hooge Rudi, Weigelt Cecilia, Eistrup Carl, Fogh Jens, Gieselmann Volkmar. Induction of tolerance to human arylsulfatase A in a mouse model of metachromatic leukodystrophy. Molecular Medicine 2007;13(9-10):471-479. https://doi.org/10.2119/2007-00063.matzner
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2005

Cramer Alexander, Kleiner Sandra, Westermann Martin, Meissner Anja, Lange Anika, Friedrich Karlheinz. Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3. Journal of Cellular Biochemistry 2005;95(4):805-816. https://doi.org/10.1002/jcb.20459
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Fitzgerald Justine, Tsareva Svetlana A., Poehlmann Tobias G., Berod Luciana, Meissner Anja, Cornvinus Florian M., Wiederanders Bernd KarlheinzFriedrich, Pfitzner Edith, Markert Udo R., Friedrich Karlheinz. Leukemia inhibitory factor triggers activation of signal transducer and activator of transcription 3, proliferation, invasiveness, and altered protease expression in choriocarcinoma cells. The International Journal of Biochemistry & Cell Biology 2005;37(11):2284-2296. https://doi.org/10.1016/j.biocel.2005.02.025
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Poehlmann T.G., Fitzgerald J.S., Meissner Anja, Wengenmayer T., Schleussner E., Friedrich K., Markert U.R.. Trophoblast invasion: tuning through LIF, signalling via Stat3. Placenta 2005;26:S37-S41. https://doi.org/10.1016/j.placenta.2005.01.007
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Elucidating mechanistic pathways of ambient particulate matter pollution on the cerebral vasculature

Investigating the Cause and Focusing on Treating Heart Failure-Related Target Organ Damage

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