Physiologie

  1. Universität
  2. Fakultäten
  3. Medizinische Fakultät
  4. Lehrstühle und Professuren
  5. Physiologie
  6. Team Prof. Dr. Anja Meissner
  7. Prof. Dr. Anja Meissner

Prof. Dr. Anja Meissner

Inhaberin Professur für Physiologie
Physiologie
Telefon: +49 (0)821 598 - 71174
E-Mail:
Raum: 1006 (Sigma-Technopark Gebäude 10)
Adresse: Werner-von-Siemens-Straße 6 (Sigma Technopark), 86159 Augsburg

Vita

Ausbildung

 

2019

Dozentur in kardiovaskulärer Physiologie, Lund Universität, Schweden
 

2004 - 2009

Dissertation in Zellbiologie, Universität Rostock
 

1999 - 2004
Diplomstudium Ernährungswissenschaften, Universität Jena

 

 

 

Beruflicher Werdegang

Seit 2022
W2-Professur für Physiologie, Universität Augsburg
 

Seit 2020

Senior Lecturer, Lund Universität, Schweden
 

2017 - 2020

Associate Senior Lecturer, Lund Universität, Schweden
 

Seit 2017

Gastwissenschaftlerin, Deutsches Zentrum für Neurodegenerative Erkrankungen Bonn
 

2017

Wissenschaftlerin – AG Leiterin, Universitätsklinikum Bonn, Klinik für Neurologie

 

2016

Gastwissenschaftlerin, Westfälische-Wilhelms-Universität Münster, Klinik für Neurologie

 

2013 - 2016

Marie Curie Research Fellow, IDIBAPS Barcelona, Spanien

 

2008 - 2012
Post-doc, University of Toronto, Department of Physiology, Kanada

 

2004 - 2007

Promotionsstudentin, Universität Rostock, Oscar Langendorff Institut für Physiologie

 

 

 

Auszeichnungen und Preise

 

2019

Reisestipendium Society for Microcirculation (2.000 €)
Dieser Reisepreis wurde unter unabhängigen Nachwuchswissenschaftlerinnen zur Förderung internationaler Sichtbarkeit verliehen.

 

2016

Wallenberg Molecular Medicine Fellowship (2 Mio €)
 

2015

DAAD-Stipendium für zurückkehrende Wissenschaftler (9.000 €)
 

2013

Marie-Curie-Stipendium der Europäischen Kommission (200.000 €)

Publikationen

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2005

2024
Kritsilis Marios, Vanherle Lotte, Rosenholm Marko, in 't Zandt René, Yao Yuan, Swanberg Kelley M., Weikop Pia, Gottschalk Michael, Shanbhag Nagesh C., Luo Jiebo, Boster Kimberly, Nedergaard Maiken, Meissner Anja, Lundgaard Iben. Loss of glymphatic homeostasis in heart failure. Brain 2024; https://doi.org/10.1093/brain/awae411
BibTeX | RIS | DOI
Meissner Anja, Liefke Jonas, Matthes Frank, Morsing Eva, Ley David, Hedström Erik. Plasma biomarkers of inflammation associate with blood pressure and arterial stiffness in adolescents after very preterm birth. Cardiovascular Research 2024;cvae192. https://doi.org/10.1093/cvr/cvae192
BibTeX | RIS | DOI
Matuskova Hana, Porschen Lisa T., Matthes Frank, Lindgren Arne G., Petzold Gabor C., Meissner Anja. Spatiotemporal sphingosine-1-phosphate receptor 3 expression within the cerebral vasculature after ischemic stroke. iScience 2024;110031. https://doi.org/10.1016/j.isci.2024.110031
BibTeX | RIS | DOI

2023
Meissner Anja, Garcia-Serrano Alba M., Vanherle Lotte, Rafiee Zeinab, Don-Doncow Nicholas, Skoug Cecilia, Larsson Sara, Gottschalk Michael, Magnusson Martin, Duarte João M. N.. Alterations to cerebral perfusion, metabolite profiles, and neuronal morphology in the hippocampus and cortex of male and female mice during chronic exposure to a high-salt diet. International Journal of Molecular Sciences 2023;24(1):300. https://doi.org/10.3390/ijms24010300
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Malm Tillgren Sofia, Nieto-Fontarigo Juan José, Cerps Samuel, Ramu Sangeetha, Menzel Mandy, Mahmutovic Persson Irma, Meissner Anja, Akbarshahi Hamid, Uller Lena. C57Bl/6N mice have an attenuated lung inflammatory response to dsRNA compared to C57Bl/6J and BALB/c mice. Journal of Inflammation 2023;20(1):6. https://doi.org/10.1186/s12950-023-00331-4
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Skoug Cecilia, Erdogan Hüseyin, Vanherle Lotte, Vieira João P. P., Matthes Frank, Eliasson Lena, Meissner Anja, Duarte João M. N.. Density of sphingosine-1-phosphate receptors is altered in cortical nerve-terminals of insulin-resistant Goto-Kakizaki rats and diet-induced obese mice. Neurochemical Research 2023;49:338-347. https://doi.org/10.1007/s11064-023-04033-4
PDF | BibTeX | RIS | DOI
Porschen Lisa, Matuskova Hana, Matthes Frank, Meissner Anja. High-fat diet and its effects on altered S1P signaling after stroke [Abstract]. Journal of Neurochemistry 2023;166(S1):102. https://doi.org/10.1111/jnc.15897
BibTeX | RIS | DOI
Vanherle Lotte, Matthes Frank, Uhl Franziska E., Meissner Anja. Ivacaftor therapy post myocardial infarction augments systemic inflammation and evokes contrasting effects with respect to tissue inflammation in brain and lung. Biomedicine & Pharmacotherapy 2023;162:114628. https://doi.org/10.1016/j.biopha.2023.114628
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Jujic Amra, Vieira João P. P., Matuskova Hana, Nilsson Peter M., Lindblad Ulf, Olsen Michael H., Duarte João M. N., Meissner Anja, Magnusson Martin. Plasma galectin-4 levels are increased after stroke in mice and humans. International Journal of Molecular Sciences 2023;24(12):10064. https://doi.org/10.3390/ijms241210064
PDF | BibTeX | RIS | DOI
Goktas Sevilay Sahoglu, Vanherle Lotte, Rafiee Zeinab, Duarte Joao, Meissner Anja. Sex-specific cardiovascular responses to long-term high-salt diet [Abstract]. Journal of Vascular Research 2023;60(Supplement 1):30-31. https://doi.org/10.1159/000533846
BibTeX | RIS | DOI
Vanherle Lotte, Corrigan Alex, Vassallo Stefania, Meissner Anja. Spatiotemporal profile of myocardial infarction-induced brain alterations [Abstract]. Journal of Neurochemistry 2023;166(S1):98. https://doi.org/10.1111/jnc.15897
BibTeX | RIS | DOI
Matuskova Hana, Matthes Frank, Petzold Gabor, Meissner Anja. Sphingosine-1-phosphate receptor 3 signaling is a critical modulator of stroke outcome [Abstract]. Journal of Vascular Research 2023;60(Supplement 1):19. https://doi.org/10.1159/000533846
BibTeX | RIS | DOI
Vanherle Lotte, Matthes Frank, Meissner Anja. Targeting sphingosine-1-phosphate signaling in hypertension - a new treatment opportunity [Abstract]. Journal of Vascular Research 2023;60(Supplement 1):16-17. https://doi.org/10.1159/000533846
BibTeX | RIS | DOI

2022
Uhl Franziska E., Vanherle Lotte, Meissner Anja. Cystic fibrosis transmembrane regulator correction attenuates heart failure-induced lung inflammation. Frontiers in Immunology 2022;13:928300. https://doi.org/10.3389/fimmu.2022.928300
PDF | BibTeX | RIS | DOI
Vanherle Lotte, Lidington Darcy, Vassallo Stefania, Skoug Cecilia, Bolz Steffen-Sebastian, Meissner Anja. Restoring heart failure-induced long-term memory impairment by targeting the cystic fibrosis transmembrane regulator [Abstract]. Journal of Neurochemistry 2022;162(S1):118. https://doi.org/10.1111/jnc.15675
BibTeX | RIS | DOI
Vanherle Lotte, Lidington Darcy, Uhl Franziska E., Steiner Saskia, Vassallo Stefania, Skoug Cecilia, Duarte Joao M. N., Ramu Sangeetha, Uller Lena, Desjardins Jean-François, Connelly Kim A., Bolz Steffen-Sebastian, Meissner Anja. Restoring myocardial infarction-induced long-term memory impairment by targeting the cystic fibrosis transmembrane regulator. eBioMedicine 2022;86:104384. https://doi.org/10.1016/j.ebiom.2022.104384
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Skoug Cecilia, Martinsson Isak, Gouras Gunnar K., Meissner Anja, Duarte João M. N.. Sphingosine 1-phoshpate receptors are located in synapses and control spontaneous activity of mouse neurons in culture. Neurochemical Research 2022;47(10):3114-3125. https://doi.org/10.1007/s11064-022-03664-3
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Uhl Franziska E., Vanherle Lotte, Matthes Frank, Meissner Anja. Therapeutic CFTR correction normalizes systemic and lung-specific S1P level alterations associated with heart failure. International Journal of Molecular Sciences 2022;23(2):866. https://doi.org/10.3390/ijms23020866
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2021
Matthes Frank, Matuskova Hana, Arkelius Kajsa, Ansar Saema, Lundgaard Iben, Meissner Anja. An improved method for physical separation of cerebral vasculature and parenchyma enables detection of blood-brain-barrier dysfunction. NeuroSci 2021;2(1):59-74. https://doi.org/10.3390/neurosci2010004
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Battistella Roberta, Kritsilis Marios, Matuskova Hana, Haswell Douglas, Cheng Anne Xiaoan, Meissner Anja, Nedergaard Maiken, Lundgaard Iben. Not all lectins are equally suitable for labeling rodent vasculature. International Journal of Molecular Sciences 2021;22(21):11554. https://doi.org/10.3390/ijms222111554
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Jujic Amra, Matthes Frank, Vanherle Lotte, Petzka Henning, Orho-Melander Marju, Nilsson Peter M., Magnusson Martin, Meissner Anja. Plasma S1P (Sphingosine-1-Phosphate) links to hypertension and biomarkers of inflammation and cardiovascular disease: findings from a translational investigation. Hypertension 2021;78(1):195-209. https://doi.org/10.1161/hypertensionaha.120.17379
BibTeX | RIS | DOI
Don-Doncow Nicholas, Vanherle Lotte, Matthes Frank, Petersen Sine Kragh, Matuskova Hana, Rattik Sara, Härtlova Anetta, Meissner Anja. Simvastatin therapy attenuates memory deficits that associate with brain monocyte infiltration in chronic hypercholesterolemia. npj Aging and Mechanisms of Disease 2021;7(1):19. https://doi.org/10.1038/s41514-021-00071-w
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2020
Vanherle Lotte, Matuskova Hana, Don-Doncow Nicholas, Uhl Franziska E., Meissner Anja. Improving cerebrovascular function to increase neuronal recovery in neurodegeneration associated to cardiovascular disease. Frontiers in Cell and Developmental Biology 2020;8:53. https://doi.org/10.3389/fcell.2020.00053
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Vanherle Lotte, Uhl Franziska Elisabeth, Matthes Frank, Meissner Anja. Targeting cerebrovascular sphingosine‐1‐phosphate signaling to treat heart failure‐induced brain dysfunction. The FASEB Journal 2020;34(S1):1. https://doi.org/10.1096/fasebj.2020.34.s1.05599
BibTeX | RIS | DOI
Don-Doncow Nicholas, Vanherle Lotte, Matthes Frank, Petzka Henning, Meissner Anja. Therapeutic inhibition of sphingosine kinase SphK2 lowers blood pressure levels in an experimental model of hypertension by reducing CD4+ T‐cell responses. The FASEB Journal 2020;34(S1):1. https://doi.org/10.1096/fasebj.2020.34.s1.04663
BibTeX | RIS | DOI

2019
Lidington Darcy, Fares Jessica C., Uhl Franziska E., Dinh Danny D., Kroetsch Jeffrey T., Sauvé Meghan, Malik Firhan A., Matthes Frank, Vanherle Lotte, Adel Arman, Momen Abdul, Zhang Hangjun, Aschar-Sobbi Roozbeh, Foltz Warren D., Wan Hoyee, Sumiyoshi Manabu, Macdonald R. Loch, Husain Mansoor, Backx Peter H., Heximer Scott P., Meissner Anja, Bolz Steffen-Sebastian. CFTR therapeutics normalize cerebral perfusion deficits in mouse models of heart failure and subarachnoid hemorrhage. JACC: Basic to Translational Science 2019;4(8):940-958. https://doi.org/10.1016/j.jacbts.2019.07.004
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Munk Anne Sofie, Wang Wei, Bèchet Nicholas Burdon, Eltanahy Ahmed M., Cheng Anne Xiaoan, Sigurdsson Björn, Benraiss Abdellatif, Mäe Maarja A., Kress Benjamin Travis, Kelley Douglas H., Betsholtz Christer, Møllgård Kjeld, Meissner Anja, Nedergaard Maiken, Lundgaard Iben. PDGF-B is required for development of the glymphatic system. Cell Reports 2019;26(11):2955-2969.e3. https://doi.org/10.1016/j.celrep.2019.02.050
PDF | BibTeX | RIS | DOI
Salas-Perdomo Angélica, Miró-Mur Francesc, Gallizioli Mattia, Brait Vanessa H., Justicia Carles, Meissner Anja, Urra Xabier, Chamorro Angel, Planas Anna M.. Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke. Scientific Reports 2019;9(1):8309. https://doi.org/10.1038/s41598-019-44845-5
PDF | BibTeX | RIS | DOI
Don-Doncow Nicholas, Vanherle Lotte, Zhang Yun, Meissner Anja. T-Cell accumulation in the hypertensive brain: a role for sphingosine-1-phosphate-mediated chemotaxis. International Journal of Molecular Sciences 2019;20(3):537. https://doi.org/10.3390/ijms20030537
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2018
Don-Doncow Nicholas, Zhang Yun, Rattik Sara, Björkbacka Harry, Meissner Anja. Anti-inflammatory properties of simvastatin mediate improvement of memory function in aged ApoE-/- Mice. Atherosclerosis Supplements 2018;32:98. https://doi.org/10.1016/j.atherosclerosissup.2018.04.298
BibTeX | RIS | DOI
Don‐Doncow Nicholas, Zhang Yun, Matuskova Hana, Meissner Anja. The emerging alliance of sphingosine‐1‐phosphate signalling and immune cells: from basic mechanisms to implications in hypertension. British Journal of Pharmacology 2018;176(12):1989-2001. https://doi.org/10.1111/bph.14381
BibTeX | RIS | DOI

2017
Meissner Anja. S1PR (Sphingosine-1-Phosphate Receptor) signaling in the regulation of vascular tone and blood pressure: is S1PR1 doing the trick?. Hypertension 2017;70(2):232-234. https://doi.org/10.1161/hypertensionaha.117.09200
BibTeX | RIS | DOI
Meissner Anja, Miro Francesc, Jiménez-Altayó Francesc, Jurado Andrés, Vila Elisabet, Planas Anna M.. Sphingosine-1-phosphate signalling—a key player in the pathogenesis of Angiotensin II-induced hypertension. Cardiovascular Research 2017;113(2):123-133. https://doi.org/10.1093/cvr/cvw256
BibTeX | RIS | DOI

2016
Meissner Anja. Hypertension and the brain: a risk factor for more than heart disease. Cerebrovascular Diseases 2016;42(3-4):255-262. https://doi.org/10.1159/000446082
BibTeX | RIS | DOI
Meissner Anja, Minnerup Jens, Soria Guadalupe, Planas Anna M. Structural and functional brain alterations in a murine model of Angiotensin II-induced hypertension. Journal of Neurochemistry 2016;140(3):509-521. https://doi.org/10.1111/jnc.13905
BibTeX | RIS | DOI

2015
Malik Firhan A., Meissner Anja, Semenkov Illya, Molinski Steven, Pasyk Stan, Ahmadi Saumel, Bui Hai H., Bear Christine E., Lidington Darcy, Bolz Steffen-Sebastian. Sphingosine-1-Phosphate is a novel regulator of cystic fibrosis transmembrane conductance regulator (CFTR) activity. PLOS ONE 2015;10(6):e0130313. https://doi.org/10.1371/journal.pone.0130313
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Yagi Kenji, Lidington Darcy, Wan Hoyee, Fares Jessica C., Meissner Anja, Sumiyoshi Manabu, Ai Jinglu, Foltz Warren D., Nedospasov Sergei A., Offermanns Stefan, Nagahiro Shinji, Macdonald R. Loch, Bolz Steffen-Sebastian. Therapeutically targeting tumor necrosis factor-α/Sphingosine-1-Phosphate signaling corrects myogenic reactivity in subarachnoid hemorrhage. Stroke 2015;46(8):2260-2270. https://doi.org/10.1161/strokeaha.114.006365
BibTeX | RIS | DOI
Meissner Anja, Visanji Naomi P., Momen M. Abdul, Feng Rui, Francis Beverly M., Bolz Steffen‐Sebastian, Hazrati Lili‐Naz. Tumor necrosis factor‐α underlies loss of cortical dendritic spine density in a mouse model of congestive heart failure. Journal of the American Heart Association 2015;4(5). https://doi.org/10.1161/jaha.115.001920
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2012
Yang Jingli, Hossein Noyan-Ashraf M., Meissner Anja, Voigtlaender-Bolz Julia, Kroetsch Jeffrey T., Foltz Warren, Jaffray David, Kapoor Amita, Momen Abdul, Heximer Scott P., Zhang Hangjun, van Eede Matthijs, Henkelman R. Mark, Matthews Stephen G., Lidington Darcy, Husain Mansoor, Bolz Steffen-Sebastian. Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α–dependent activation of Sphingosine-1-Phosphate signaling. Circulation 2012;126(2):196-206. https://doi.org/10.1161/circulationaha.111.039644
BibTeX | RIS | DOI
Meissner Anja, Yang Jingli, Kroetsch Jeffrey T., Sauvé Meghan, Dax Hendrik, Momen Abdul, Noyan-Ashraf M. Hossein, Heximer Scott, Husain Mansoor, Lidington Darcy, Bolz Steffen-Sebastian. Tumor necrosis factor-α–mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological Sphingosine-1-Phosphate signaling in a mouse model of heart failure. Circulation 2012;125(22):2739-2750. https://doi.org/10.1161/circulationaha.111.047316
BibTeX | RIS | DOI

2011
Meissner Anja, Bolz Steffen‐Sebastian. TNFα affects sphingosine‐1‐phosphate signaling through modulating the expression of the cystic fibrosis transmembrane regulator (CFTR) in vascular smooth muscle cells. The FASEB Journal 2011;25(S1):1026.36. https://doi.org/10.1096/fasebj.25.1_supplement.1026.36
BibTeX | RIS | DOI
Kroetsch Jeffrey Thomas, Meissner Anja, Momen Abdul, Husain Mansoor, Bolz Steffen‐Sebastian. TNFα is central to the augmented myogenic response of skeletal muscle resistance arteries in heart failure. The FASEB Journal 2011;25(S1):1026.12. https://doi.org/10.1096/fasebj.25.1_supplement.1026.12
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2010
Lidington Darcy, Peter Bernhard Friedrich, Meissner Anja, Kroetsch Jeff, Pitson Stuart, Pohl Ulrich, Bolz Steffen‐Sebastian. Serine 225 phosphorylation governs the localization and function of sphingosine kinase 1 in resistance arteries. The FASEB Journal 2010;24(S1). https://doi.org/10.1096/fasebj.24.1_supplement.777.3
BibTeX | RIS | DOI
Malik F. A., Bolz S. S., Meissner Anja, Bear C. E.. Sphingosine-1-Phosphate (S1P) acutely modulates the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) protein in an AMPK-dependent manner. The Canadian Journal of Cardiology 2010;26:33D.
BibTeX | RIS
Hoefer Judith, Azam M. Ali, Kroetsch Jeffrey T.E., Leong-Poi Howard, Momen M. Abdul, Voigtlaender-Bolz Julia, Scherer Elias Q., Meissner Anja, Bolz Steffen-Sebastian, Husain Mansoor. Sphingosine-1-Phosphate–dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction. Circulation Research 2010;107(7):923-933. https://doi.org/10.1161/circresaha.110.226464
BibTeX | RIS | DOI
Malik Firhan Atir, Meissner Anja, Bear Christine, Bolz Steffen Sebastian. Sphingosine‐1‐Phosphate acutely modulates the CFTR (Cystic Fibrosis Transmembrane Regulator) transporter in an AMPK‐dependent manner. The FASEB Journal 2010;24(S1):609.1. https://doi.org/10.1096/fasebj.24.1_supplement.609.1
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2009
Lidington Darcy, Peter Bernhard Friedrich, Meissner Anja, Kroetsch Jeffrey T., Pitson Stuart M., Pohl Ulrich, Bolz Steffen-Sebastian. The phosphorylation motif at serine 225 governs the localization and function of sphingosine kinase 1 in resistance arteries. Arteriosclerosis, Thrombosis, and Vascular Biology 2009;29(11):1916-1922. https://doi.org/10.1161/atvbaha.109.194803
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2008
Meissner Anja, Noack Thomas. Proliferation of human lens epithelial cells (HLE-B3) is inhibited by blocking of voltage-gated calcium channels. Pflügers Archiv - European Journal of Physiology 2008;457(1):47-59. https://doi.org/10.1007/s00424-008-0514-5
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2007
Meissner Anja, Nebe Barbara, Beck Ria, Guthoff R., Noack T.. Importance of calcium and potassium currents in human lens epithelial cells (hLEC) and the effect of the calcium channel blocker mibefradil. Trace Elements and Electrolytes 2007;24(10):228-234. https://doi.org/10.5414/tep24228
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2005
Cramer Alexander, Kleiner Sandra, Westermann Martin, Meissner Anja, Lange Anika, Friedrich Karlheinz. Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3. Journal of Cellular Biochemistry 2005;95(4):805-816. https://doi.org/10.1002/jcb.20459
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Fitzgerald Justine, Tsareva Svetlana A., Poehlmann Tobias G., Berod Luciana, Meissner Anja, Cornvinus Florian M., Wiederanders Bernd KarlheinzFriedrich, Pfitzner Edith, Markert Udo R., Friedrich Karlheinz. Leukemia inhibitory factor triggers activation of signal transducer and activator of transcription 3, proliferation, invasiveness, and altered protease expression in choriocarcinoma cells. The International Journal of Biochemistry & Cell Biology 2005;37(11):2284-2296. https://doi.org/10.1016/j.biocel.2005.02.025
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Poehlmann T.G., Fitzgerald J.S., Meissner Anja, Wengenmayer T., Schleussner E., Friedrich K., Markert U.R.. Trophoblast invasion: tuning through LIF, signalling via Stat3. Placenta 2005;26:S37-S41. https://doi.org/10.1016/j.placenta.2005.01.007
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