Prof. Dr. Jan Lipfert

Lehrstuhlinhaber
Experimentalphysik I
Telefon: +49 821 598 3300
E-Mail:
Raum: 340 (R)
Sprechzeiten: Anmeldung im Sekretariat
Adresse: Universitätsstraße 1 (Physik Nord), 86159 Augsburg

Lebenslauf

  • seit 2024:    Professor (W3), Institut für Physik
                        Universität Augsburg
  • seit 2022:    Professor ("hoogleraar"), Department of Physics
                        Universität Utrecht, Niederlande
  • 2018-2022: Prodekan, Fakultät für Physik
                        LMU München
  • 2013-2022: Professor (W2, tenured seit 2018), Fakultät für Physik
                        
    LMU München
  • 2008-2013: Post doc and Veni fellow, Department of Bionanoscience
                        TU Delft, Niederlande
  • 2002-2008: Ph.D. in Physik
                        Stanford University, USA
  • 2001-2002: M.Sc. in Physik
                       University of Illinois at Urbana-Champaign, IL, USA
  • 2000-2001: M.Phil. in Physik und Mathematik
                      
     Universität Uppsala, Schweden
  • 1998-2000Vordiplom in Volkswirtschaftslehre
                       
    Universität Heidelberg
  • 1998-2000Vordiplom in Physik
                       
    Universität Heidelberg

Auszeichnungen und Preise

  • 2022     Lehrpreis der Fakultät für Biologie ("BioPlus"), LMU München
  • 2021     Lehrpreis der Fakultät für Chemie und Pharmazie ("Preis für gute Lehre"), LMU München
  • 2020     ERC Consolidator Grant (Beginn: 2022)
  • 2020     Lehrpreis der Fakultät für Biologie ("BioPlus"), LMU München
  • 2019     CeNS publication award in der Kategorie "scientific breakthrough"
  • 2019     Lehrpreis der Fakultät für Physik für die beste Bachelorvorlesung ("Goldener Sommerfeld"), LMU München
  • 2018     Lehrpreis der Fakultät für Chemie und Pharmazie ("Preis für gute Lehre"), LMU München
  • 2018     F1000 section head "Methods in Biological Physics"
  • 2016     Forschung@LMU Preis für studentische Forschung
  • 2016     CeNS publication award in der Kategorie "scientific breakthrough"
  • 2010-2013     Veni fellowship der Netherlands Organisation for Scientific Research (NWO)
  • 2007     Margaret C. Etter Student Lecturer Award der American Crystallographic Association
  • 2006     Student travel award für das 2006 SAS meeting in Kyoto, Japan
  • 2001-2002     Fulbright Stipendium
  • 2001-2004     Stipendium der Studienstiftung des Deutschen Volkes

Forschungsschwerpunkte

We are fascinated by how biological macromolecules (DNA, RNA, and proteins) adopt their three-dimensional shapes, make specific interactions, can deform under external forces and torques, and undergo conformational transitions to carry out the biological functions they have evolved to do. We use a range of biophysical tools, in particular single-molecule magnetic tweezers and solution X-ray scattering, to provide insights into the structure and mechanisms of these biological machines.

Publikationen

2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004

2025

Samuel Stubhan, Anna V. Baptist, Caroline Körösy, Alessandra Narducci, Gustavo Gabriel Moya Muñoz, Nicolas Wendler, Aidin Lak, Michael Sztucki, Thorben Cordes und Jan Lipfert
Determination of absolute intramolecular distances in proteins using anomalous X-ray scattering interferometry

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2024

Stefanie D. Pritzl, Alptuğ Ulugöl, Caroline Körösy, Laura Filion und Jan Lipfert
Accurate drift-invariant single-molecule force calibration using the Hadamard variance

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Aidin Lak, Yihao Wang, Pauline J. Kolbeck, Christoph Pauer, Mohammad Suman Chowdhury, Marco Cassani, Frank Ludwig, Thilo Viereck, Florian Selbach, Philip Tinnefeld, Meinhard Schilling, Tim Liedl, Joe Tavacoli und Jan Lipfert
Cooperative dynamics of DNA-grafted magnetic nanoparticles optimize magnetic biosensing and coupling to DNA origami

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Samuel Stubhan, Anna V. Baptist, Caroline Körösy, Alessandra Narducci, Gustavo Gabriel Moya Muñoz, Nicolas Wendler, Aidin Lak, Michael Sztucki, Thorben Cordes und Jan Lipfert
Determination of absolute intramolecular distances in proteins by anomalous X-ray scattering interferometry

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Yi-Yun Lin, Peter Müller, Evdoxia Karagianni, Nicola Hepp, Felix Mueller-Planitz, Willem Vanderlinden und Jan Lipfert
Epigenetic histone modifications H3K36me3 and H4K5/8/12/16ac induce open polynucleosome conformations via different mechanisms

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Marjolein de Jager, Pauline J. Kolbeck, Willem Vanderlinden, Jan Lipfert und Laura Filion
Exploring protein-mediated compaction of DNA by coarse-grained simulations and unsupervised learning

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Pauline J. Kolbeck, Marjolein de Jager, Margherita Gallano, Tine Brouns, Ben Bekaert, Wout Frederickx, Sebastian F. Konrad, Siska Van Belle, Frauke Christ, Steven De Feyter, Zeger Debyser, Laura Filion, Jan Lipfert und Willem Vanderlinden
HIV integrase compacts viral DNA into biphasic condensates

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Li-Ting Chen, Myrthe Jager, Dàmi Rebergen, Geertruid J. Brink, Tom van den Ende, Willem Vanderlinden, Pauline Kolbeck, Marc Pagès-Gallego, Ymke van der Pol, Nicolle Besselink, Norbert Moldovan, Nizar Hami, Wigard Kloosterman, Hanneke van Laarhoven, Florent Mouliere, Ronald Zweemer, Jan Lipfert, Sarah Derks, Alessio Marcozzi und Jeroen de Ridder
Nanopore-based consensus sequencing enables accurate multimodal tumor cell-free DNA profiling

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Magnus S. Bauer, Sophia Gruber, Adina Hausch, Marcelo C. R. Melo, Priscila S. F. C. Gomes, Thomas Nicolaus, Lukas F. Milles, Hermann E. Gaub, Rafael C. Bernardi und Jan Lipfert
Single-molecule force stability of the SARS-CoV-2–ACE2 interface in variants-of-concern

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Pauline J. Kolbeck, Miloš Tišma, Brian T. Analikwu, Willem Vanderlinden, Cees Dekker und Jan Lipfert
Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and single-molecule experiments

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Hana Dohnalová, Mona Seifert, Eva Matoušková, Misha Klein, Flávia S. Papini, Jan Lipfert, David Dulin und Filip Lankaš
Temperature-dependent twist of double-stranded RNA probed by magnetic tweezer experiments and molecular dynamics simulations

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2023

Pauline J. Kolbeck, Mihir Dass, Irina V. Martynenko, Relinde J. A. van Dijk-Moes, Kelly J. H. Brouwer, Alfons van Blaaderen, Willem Vanderlinden, Tim Liedl und Jan Lipfert
DNA origami fiducial for accurate 3D atomic force microscopy imaging

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Yi-Yun Lin, Tine Brouns, Pauline J. Kolbeck, Willem Vanderlinden und Jan Lipfert
High-yield ligation-free assembly of DNA constructs with nucleosome positioning sequence repeats for single-molecule manipulation assays

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Christian Gebhardt, Pascal Bawidamann, Konstantin Schütze, Gabriel G. Moya Muñoz, Anna-Katharina Spring, Douglas A. Griffith, Jan Lipfert und Thorben Cordes
Labelizer: systematic selection of protein residues for covalent fluorophore labeling

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Pauline J. Kolbeck, Dihia Benaoudia, Léa Chazot-Franguiadakis, Gwendoline Delecourt, Jérôme Mathé, Sha Li, Romeo Bonnet, Pascal Martin, Jan Lipfert, Anna Salvetti, Mordjane Boukhet, Véronique Bennevault, Jean-Christophe Lacroix, Philippe Guégan und Fabien Montel
Thermally switchable nanogate based on polymer phase transition

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2022

Sophia Gruber, Achim Löf, Adina Hausch, Fabian Kutzki, Res Jöhr, Tobias Obser, Gesa König, Reinhard Schneppenheim, Camilo Aponte-Santamaría, Frauke Gräter, Maria A. Brehm, Martin Benoit und Jan Lipfert
A conformational transition of the D'D3 domain primes von Willebrand factor for multimerization

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Magnus S. Bauer, Sophia Gruber, Adina Hausch, Priscila S. F. C. Gomes, Lukas F. Milles, Thomas Nicolaus, Leonard C. Schendel, Pilar López Navajas, Erik Procko, Daniel Lietha, Marcelo C. R. Melo, Rafael C. Bernardi, Hermann E. Gaub und Jan Lipfert
A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions

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Willem Vanderlinden, Enrico Skoruppa, Pauline J. Kolbeck, Enrico Carlon und Jan Lipfert
DNA fluctuations reveal the size and dynamics of topological domains

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Sebastian F. Konrad, Willem Vanderlinden und Jan Lipfert
Quantifying epigenetic modulation of nucleosome breathing by high-throughput AFM imaging

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Sergio Cruz-León, Willem Vanderlinden, Peter Müller, Tobias Forster, Georgina Staudt, Yi-Yun Lin, Jan Lipfert und Nadine Schwierz
Twisting DNA by salt

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2021

Willem Vanderlinden und Jan Lipfert
A gentle twist on DNA

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Sebastian Konrad, Willem Vanderlinden und Jan Lipfert
A high-throughput pipeline to determine DNA and nucleosome conformations by AFM imaging

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Sebastian F. Konrad, Willem Vanderlinden, Wout Frederickx, Tine Brouns, Björn H. Menze, Steven De Feyter und Jan Lipfert
High-throughput AFM analysis reveals unwrapping pathways of H3 and CENP-A nucleosomes

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Pauline J. Kolbeck, Willem Vanderlinden, Gerd Gemmecker, Christian Gebhardt, Martin Lehmann, Aidin Lak, Thomas Nicolaus, Thorben Cordes und Jan Lipfert
Molecular structure, DNA binding mode, photophysical properties and recommendations for use of SYBR Gold

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A correction has been published: Nucleic Acids Research, Volume 49, Issue 21, 2 December 2021, Pages 12601–12602, https://doi.org/10.1093/nar/gkab1164

Ann-Kathrin Reichenwallner, Esma Vurmaz, Kristina Battis, Laura Handl, Helin Üstün, Tivadar Mach, Gabriele Hörnig, Jan Lipfert und Lukas Richter
Optical investigation of individual red blood cells for determining cell count and cellular hemoglobin concentration in a microfluidic channel

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2020

Willem Vanderlinden, Pauline J. Kolbeck, Franziska Kriegel, Philipp U. Walker und Jan Lipfert
A benchmark data set for the mechanical properties of double-stranded DNA and RNA under torsional constraint

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Shan Zhao, Mihail Ivilinov Todorov, Ruiyao Cai, Rami Al-Maskari, Hanno Steinke, Elisabeth Kemter, Hongcheng Mai, Zhouyi Rong, Martin Warmer, Karen Stanic, Oliver Schoppe, Johannes Christian Paetzold, Benno Gesierich, Milagros N. Wong, Tobias B. Huber, Marco Duering, Oliver Thomas Bruns, Bjoern Menze, Jan Lipfert, Victor G. Puelles, Eckhard Wolf, Ingo Bechmann und Ali Ertürk
Cellular and molecular probing of intact human organs

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Hana Dohnalová, Tomáš Dršata, Jiří Šponer, Martin Zacharias, Jan Lipfert und Filip Lankaš
Compensatory mechanisms in temperature dependence of DNA double helical structure: bending and elongation

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Sophia Gruber, Achim Löf, Steffen M. Sedlak, Martin Benoit, Hermann E. Gaub und Jan Lipfert
Designed anchoring geometries determine lifetimes of biotin–streptavidin bonds under constant load and enable ultra-stable coupling

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Katharina Ott, Linda Martini, Jan Lipfert und Ulrich Gerland
Dynamics of the buckling transition in double-stranded DNA and RNA

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Aidin Lak, Tamara Kahmann, Simon Jakob Schaper, Jaroslava Obel, Frank Ludwig, Peter Müller-Buschbaum und Jan Lipfert
The dissociation rate of acetylacetonate ligands governs the size of ferrimagnetic zinc ferrite nanocubes

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Willem Vanderlinden, Pauline J. Kolbeck, Tine Brouns, Zeger Debyser und Jan Lipfert
The free energy landscape of retroviral integration and molecular mechanisms of DNA compaction [Abstract]

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Sophia Gruber, Achim Löf, Tobias Obser, Maria A. Brehm, Martin Benoit und Jan Lipfert
The low-force response of Von Willebrand factor revealed by magnetic tweezers [Abstract]

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Thomas Zettl, Xuesong Shi, Steve Bonilla, Steffen M. Sedlak, Jan Lipfert und Daniel Herschlag
The structural ensemble of a Holliday junction determined by X-ray scattering interference

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2019

Abhijeet Pataskar, Willem Vanderlinden, Johannes Emmerig, Aditi Singh, Jan Lipfert und Vijay K. Tiwari
Deciphering the gene regulatory landscape encoded in DNA biophysical features

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Achim Löf, Philipp U. Walker, Steffen M. Sedlak, Sophia Gruber, Tobias Obser, Maria A. Brehm, Martin Benoit und Jan Lipfert
Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor

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Willem Vanderlinden, Pauline J. Kolbeck, Wout Frederickx, Sebastian F. Konrad, Thomas Nicolaus, Carola Lampe, Alexander S. Urban, Cécile Moucheron und Jan Lipfert
Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

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Willem Vanderlinden, Tine Brouns, Philipp U. Walker, Pauline J. Kolbeck, Lukas F. Milles, Wolfgang Ott, Philipp C. Nickels, Zeger Debyser und Jan Lipfert
The free energy landscape of retroviral integration

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2018

Philipp U. Walker, Willem Vanderlinden und Jan Lipfert
Dynamics and energy landscape of DNA plectoneme nucleation

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Tine Brouns, Herlinde De Keersmaecker, Sebastian F. Konrad, Noriyuki Kodera, Toshio Ando, Jan Lipfert, Steven De Feyter und Willem Vanderlinden
Free energy landscape and dynamics of supercoiled DNA by high-speed atomic force microscopy

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Thomas Zettl, Rebecca S. Mathew, Xuesong Shi, Sebastian Doniach, Daniel Herschlag, Pehr A. B. Harbury und Jan Lipfert
Gold nanocrystal labels provide a sequence–to–3D structure map in SAXS reconstructions

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Franziska Kriegel, Willem Vanderlinden, Thomas Nicolaus, Angelika Kardinal und Jan Lipfert
Measuring single-molecule twist and torque in multiplexed magnetic tweezers

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Jan Lipfert
Parallelized magnetic torque tweezers probe DNA mechanics and viral integration [Abstract]

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Miloš T. Ivanović, Linda K. Bruetzel, Roman Shevchuk, Jan Lipfert und Jochen S. Hub
Quantifying the influence of the ion cloud on SAXS profiles of charged proteins

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Maarten M. van Oene, Seungkyu Ha, Tessa Jager, Mina Lee, Francesco Pedaci, Jan Lipfert und Nynke H. Dekker
Quantifying the precision of single-molecule torque and twist measurements using Allan variance

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Thomas Zettl, Rhiju Das, Pehr A. B. Harbury, Daniel Herschlag, Jan Lipfert, Rebecca S. Mathew und Xuesong Shi
Recording and analyzing nucleic acid distance distributions with X‐ray scattering interferometry (XSI)

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Nadine Harrer, Christina E. M. Schindler, Linda K. Bruetzel, Ignasi Forné, Johanna Ludwigsen, Axel Imhof, Martin Zacharias, Jan Lipfert und Felix Mueller-Planitz
Structural architecture of the nucleosome remodeler ISWI determined from cross-linking, mass spectrometry, SAXS, and modeling

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Miloš T. Ivanović, Linda K. Bruetzel, Jan Lipfert und Jochen S. Hub
Temperature‐dependent atomic models of detergent micelles refined against small‐angle X‐ray scattering data

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Franziska Kriegel, Christian Matek, Tomáš Dršata, Klara Kulenkampff, Sophie Tschirpke, Martin Zacharias, Filip Lankaš und Jan Lipfert
The temperature dependence of the helical twist of DNA

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Linda K. Bruetzel, Philipp U. Walker, Thomas Gerling, Hendrik Dietz und Jan Lipfert
Time-resolved small-angle X-ray scattering reveals millisecond transitions of a DNA origami switch

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2017

Maarten M. van Oene, Laura E. Dickinson, Bronwen Cross, Francesco Pedaci, Jan Lipfert und Nynke H. Dekker
Applying torque to the Escherichia coli flagellar motor using magnetic tweezers

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A Corrigendum to this article was published at: https://doi.org/10.1038/srep46980

Hayk Vardanyan, Simon Sindbert, Stanislav Kalinin, Christian A. Hanke, Tomasz Soltynski, Grzegorz Lach, Danilo Springstubbe, Bettina Apel, Edward Snell, Thomas D. Grant, Jan Lipfert, Sabine Müller, Janusz M. Bujnicki, Holger Gohlke und Claus A. M. Seidel
FRET, SAXS and molecular simulations resolve the solution structures of three coexisting conformers of flexible RNA four-way junction [Abstract]

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F. Kriegel und Jan Lipfert
Magnetic (torque) tweezers to probe mechanical properties of dsDNA [Abstract]

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L. K. Brützel, P. U. Walker, T. Gerling, H. Dietz und Jan Lipfert
Monitoring conformational states and kinetics of DNA origami objects by small-angle X-ray scattering [Abstract]

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P. U. Walker, A. Löf und Jan Lipfert
Probing the conformational dynamics of proteins with high multiplexed magnetic tweezers [Abstract]

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Franziska Kriegel, Niklas Ermann und Jan Lipfert
Probing the mechanical properties, conformational changes, and interactions of nucleic acids with magnetic tweezers

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Franziska Kriegel, Niklas Ermann, Ruaridh Forbes, David Dulin, Nynke H. Dekker und Jan Lipfert
Probing the salt dependence of the torsional stiffness of DNA by multiplexed magnetic torque tweezers

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Steffen M. Sedlak, Linda K. Bruetzel und Jan Lipfert
Quantitative evaluation of statistical errors in small-angle X-ray scattering measurements

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Sabrina Simoncelli, Samuel Johnson, Franziska Kriegel, Jan Lipfert und Jochen Feldmann
Stretching and heating single DNA molecules with optically trapped gold–silica Janus particles

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Stefanos K. Nomidis, Franziska Kriegel, Willem Vanderlinden, Jan Lipfert und Enrico Carlon
Twist-bend coupling and the torsional response of double-stranded DNA

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2016

Linda K. Bruetzel, Stefan Fischer, Annalena Salditt, Steffen M. Sedlak, Bert Nickel und Jan Lipfert
A Mo-anode-based in-house source for small-angle X-ray scattering measurements of biological macromolecules

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Thomas Zettl, Rebecca S. Mathew, Sönke Seifert, Sebastian Doniach, Pehr A. B. Harbury und Jan Lipfert
Absolute intramolecular distance measurements with angstrom-resolution using anomalous small-angle X-ray scattering

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Linda K. Bruetzel, Thomas Gerling, Steffen M. Sedlak, Philipp U. Walker, Wenjun Zheng, Hendrik Dietz und Jan Lipfert
Conformational changes and flexibility of DNA devices observed by small-angle X-ray scattering

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Christina E. M. Schindler, Nadine Harrer, Jan Lipfert, Felix Müller-Planitz und Martin Zacharias
Integrative modeling of the ISWI chromatin remodeling enzyme from cross-linking/mass spectrometry and Saxs data

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Jochen P. Müller, Achim Löf, Salomé Mielke, Tobias Obser, Linda K. Bruetzel, Willem Vanderlinden, Jan Lipfert, Reinhard Schneppenheim und Martin Benoit
pH-dependent interactions in dimers govern the mechanics and structure of von Willebrand factor

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2015

Maarten M. van Oene, Laura E. Dickinson, Francesco Pedaci, Mariana Köber, David Dulin, Jan Lipfert und Nynke H. Dekker
Biological magnetometry: torque on superparamagnetic beads in magnetic fields

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Erratum: Phys. Rev. Lett. 120, 259901 (2018) DOI: https://doi.org/10.1103/PhysRevLett.114.218301

Magdalena Gebala, George M. Giambaşu, Jan Lipfert, Namita Bisaria, Steve Bonilla, Guangchao Li, Darrin M. York und Daniel Herschlag
Cation–anion interactions within the nucleic acid ion atmosphere revealed by ion counting

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Jan Lipfert und N. H. Dekker
De RNA helix lijkt niet altijd op die van DNA

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Korbinian Liebl, Tomas Drsata, Filip Lankas, Jan Lipfert und Martin Zacharias
Explaining the striking difference in twist-stretch coupling between DNA and RNA: a comparative molecular dynamics analysis

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David Dulin, Tao Ju Cui, Jelmer Cnossen, Margreet W. Docter, Jan Lipfert und Nynke H. Dekker
High spatiotemporal-resolution magnetic tweezers: calibration and applications for DNA dynamics

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Rifka Vlijm, Mina Lee, Jan Lipfert, Alexandra Lusser, Cees Dekker und Nynke H. Dekker
Nucleosome assembly dynamics involve spontaneous fluctuations in the handedness of tetrasomes

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Jan Lipfert, Maarten M. van Oene, Mina Lee, Francesco Pedaci und Nynke H. Dekker
Torque spectroscopy for the study of rotary motion in biological systems

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2014

Z. Yu, D. Dulin, J. P. Cnossen, M. Kober, M. M. van Oene, O. Ordu, B. A. Berghuis, T. Hensgens, Jan Lipfert und N. H. Dekker
A force calibration standard for magnetic tweezers

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Zhongbo Yu, David Dulin, Jelmer Cnossen, Mariana Köber, Maarten M. van Oene, Orkide Ordu, Bojk A. Berghuis, Toivo Hensgens, Jan Lipfert und Nynke H. Dekker
A force calibration standard for magnetic tweezers

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Fang-Chieh Chou, Jan Lipfert und Rhiju Das
Blind predictions of DNA and RNA tweezers experiments with force and torque

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Jan Lipfert, Gary M. Skinner, Johannes M. Keegstra, Toivo Hensgens, Tessa Jager, David Dulin, Mariana Köber, Zhongbo Yu, Serge P. Donkers, Fang-Chieh Chou, Rhiju Das und Nynke H. Dekker
Double-stranded RNA under force and torque: similarities to and striking differences from double-stranded DNA

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Jan Lipfert, Mina Lee, Orkide Ordu, Jacob W. J. Kerssemakers und Nynke H. Dekker
Magnetic tweezers for the measurement of twist and torque

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Maarten van Oene, Laura E. Dickinson, Francesco Pedaci, Jan Lipfert, David Dulin, Jelmer P. Cnossen, Margreet W. Docter und Nynke H. Dekker
Magnetization properties of superparamagnetic beads [Abstract]

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Rifka Vlijm, Mina Lee, Jan Lipfert, Alexandra Lusser, Cees Dekker und Nynke H. Dekker
Nucleosome dynamics involve spontaneous fluctuations in the handedness of tetrasomes [Abstract]

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Jan Lipfert, Maarten van Oene, Tessa Jager, Mina Lee, Francesco Pedaci und Nynke H. Dekker
Quantifying the resolution of single-molecule torque measurements by Allan variance [Abstract]

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Willem Vanderlinden, Jan Lipfert, Jonas Demeulemeester, Zeger Debyser und Steven De Feyter
Structure, mechanics, and binding mode heterogeneity of LEDGF/p75–DNA nucleoprotein complexes revealed by scanning force microscopy

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Ryan C. Oliver, Jan Lipfert, Daniel A. Fox, Ryan H. Lo, Justin J. Kim, Sebastian Doniach und Linda Columbus
Tuning micelle dimensions and properties with binary surfactant mixtures

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Jan Lipfert, Sebastian Doniach, Rhiju Das und Daniel Herschlag
Understanding nucleic acid–ion interactions

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2013

Ryan C. Oliver, Jan Lipfert, Daniel A. Fox, Ryan H. Lo, Sebastian Doniach und Linda Columbus
Dependence of micelle size and shape on detergent alkyl chain length and head group

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Ryan C. Oliver, Jan Lipfert und Linda Columbus
Modulating the physical properties of micelles for membrane protein investigations [Abstract]

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Jan Lipfert, Gary M. Skinner, Johannes Keegstra, Toivo Hensgens, Tessa Jager, David Dulin, Serge Donkers und Nynke H. Dekker
Probing the response of double-stranded RNA to force and torque at the single-molecule level [Abstract]

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M. Lee, Jan Lipfert, H. Sanchez, C. Wyman und N. H. Dekker
Structural and torsional properties of the RAD51-dsDNA nucleoprotein filament

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David Dulin, Jan Lipfert, M. Charl Moolman und Nynke H. Dekker
Studying genomic processes at the single-molecule level: introducing the tools and applications

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2012

Xander J. A. Janssen, Jan Lipfert, Tessa Jager, Renier Daudey, Jaap Beekman und Nynke H. Dekker
Electromagnetic torque tweezers: a versatile approach for measurement of single-molecule twist and torque

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Xander J. A. Janssen, Jan Lipfert, C. F. Daudey, Jelle van der Does, Dimitri Roos, Jaap Beekman und Nynke H. Dekker
Introducing the electromagnetic torque tweezers [Abstract]

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Adelene Y. L. Sim, Jan Lipfert, Daniel Herschlag und Sebastian Doniach
Salt dependence of the radius of gyration and flexibility of single-stranded DNA in solution probed by small-angle x-ray scattering

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Adele Y. L. Sim, Jan Lipfert, Daniel Herschlag und Sebastian Doniach
Salt dependence of the radius of gyration and flexibility of single-stranded DNA in solution probed by small-angle x-ray scattering

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S. Doniach und Jan Lipfert
Small and wide angle X-ray scattering from biological macromolecules and their complexes in solution

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Jan Lipfert, Gary M. Skinner, Serge Donkers, Zhuangxiong Huang, David Dulin, Johannes M. Keegstra, Toivo Hensgens und Nynke H. Dekker
The mechanical properties of double-stranded RNA in response to force and torque [Abstract]

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2011

Jan Lipfert, Jacob J. W. Kerssemakers, Maylon Rojer und Nynke H. Dekker
A method to track rotational motion for use in single-molecule biophysics

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Gary M. Skinner, Serge P. Donkers, Jan Lipfert, Zhuangxiong Huang und Nynke H. Dekker
Characterization of supercoiled double-stranded RNA, and comparison to double-stranded DNA [Abstract]

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Jan Lipfert, Matthew Wiggin, Jacob W. J. Kerssemakers, Francesco Pedaci und Nynke H. Dekker
Freely orbiting magnetic tweezers to directly monitor changes in the twist of nucleic acids

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Correction published at DOI: 10.1038/ncomms8192

Matthew J. Wiggin, Jan Lipfert, Roeland van Wijk, Jakob Kerssemakers und Nynke Dekker
Freely orbiting magnetic tweezers: a new twist on single molecule force spectroscopy [Abstract]

BibTeX | RIS | DOI

Jan Lipfert, Gary M. Skinner, Matthew J. Wiggin, Jacob W. K. Kerssemakers, Tessa Jager und Nynke H. Dekker
Magnetic torque tweezers and their application in probing the torsional properties of DNA, RNA, and DNA filaments [Abstract]

BibTeX | RIS | DOI

Jan Lipfert, F. Pedaci, M. Wiggin, Z. Huang, J. W. J. Kerssemakers, G. M. Skinner, S. Barland, T. Jager, M. van Oene und N. H. Dekker
O-686 Single-molecule torque spectroscopy for biophysical investigations [Abstract]

BibTeX | RIS | DOI

Published in: 8th EBSA European Biophysics Congress, August 23rd–27th 2011, Budapest, Hungary, Abstracts

Aartjan J. W. te Velthuis, Jacob W. J. Kerssemakers, Jan Lipfert und Nynke H. Dekker
Quantitative guidelines for force calibration through spectral analysis of magnetic tweezers data [Abstract]

BibTeX | RIS | DOI

Jan Lipfert, Daniel Herschlag, Sebastian Doniach und Nynke H. Dekker
RNA structure, function, and (thermo-) dynamics: a SAXS and single-molecule perspective [Abstract]

BibTeX | RIS | DOI

2010

S. Menze, C. Menze, Jan Lipfert, B. Menze und G. Harsch
Der Vorfahr aus der Bronzezeit

BibTeX | RIS

Jan Lipfert, Adelene Y. L. Sim, Daniel Herschlag und Sebastian Doniach
Dissecting electrostatic screening, specific ion binding, and ligand binding in an energetic model for glycine riboswitch folding

PDF | BibTeX | RIS | DOI

Jan Lipfert, Jacob W. J. Kerssemakers, Tessa Jager und Nynke H. Dekker
Magnetic torque tweezers: measuring torsional stiffness in DNA and RecA-DNA filaments

BibTeX | RIS | DOI

Aartjan J. W. te Velthuis, Jacob W. J. Kerssemakers, Jan Lipfert und Nynke H. Dekker
Quantitative guidelines for force calibration through spectral analysis of magnetic tweezers data

BibTeX | RIS | DOI

Gary M. Skinner, Serge P. Donkers, Jan Lipfert und Nynke H. Dekker
Supercoiling double-stranded RNA [Abstract]

BibTeX | RIS | DOI

Mona Ali, Jan Lipfert, Soenke Seifert, Daniel Herschlag und Sebastian Doniach
The ligand-free state of the TPP riboswitch: a partially folded RNA structure

BibTeX | RIS | DOI

Jan Lipfert, Peter Jan Laverman, Iris Koster, Komaraiah Palle, Mary-Ann Bjornsti und Nynke H. Dekker
Topoisomerase IB activity investigated by single molecule magnetic tweezers: mechanisms of cytotoxicity [Abstract]

BibTeX | RIS | DOI

Jan Lipfert, S. Klijnhout und N. H. Dekker
Torsional sensing of small-molecule binding using magnetic tweezers

PDF | BibTeX | RIS | DOI

2009

Vincent B. Chu, Jan Lipfert, Yu Bai, Vijay S. Pande, Sebastian Doniach und Daniel Herschlag
Do conformational biases of simple helical junctions influence RNA folding stability and specificity?

PDF | BibTeX | RIS | DOI

I. D. Vilfan, Jan Lipfert, D. A. Koster, S. G. Lemay und N. H. Dekker
Magnetic tweezers for single-molecule experiments

BibTeX | RIS | DOI

Linda Columbus, Jan Lipfert, Kalyani Jambunathan, Daniel A. Fox, Adelene Y. L. Sim, Sebastian Doniach und Scott A. Lesley
Mixing and matching detergents for membrane protein NMR structure determination

BibTeX | RIS | DOI

Linda Columbus, Jan Lipfert, Kalyani Jambunathan, Daniel A. Fox, Adelene Y. L. Sim, Sebastian Doniach und Scott A. Lesley
Mixing and matching detergents for membrane protein NMR structure determination [Abstract]

BibTeX | RIS | DOI

Jan Lipfert, Xiaomin Hao und Nynke H. Dekker
Quantitative modeling and optimization of magnetic tweezers

BibTeX | RIS | DOI

Jan Lipfert, Daniel Herschlag und Sebastian Doniach
Riboswitch conformations revealed by small-angle X-ray scattering

BibTeX | RIS | DOI

Adelene Y. L. Sim, Jan Lipfert, Daniel Herschlag und Sebastian Doniach
Scaling behavior of single stranded DNA measured by small angle x-ray scattering [Abstract]

BibTeX | RIS | DOI

Jan Lipfert, Daniel A. Koster, Igor D. Vilfan, Susanne Hage und Nynke H. Dekker
Single-molecule magnetic tweezers studies of type IB topoisomerases

BibTeX | RIS | DOI

Jan Lipfert, Sven Klijnhout und Nynke H. Dekker
Small-molecule binding to DNA under tension and twist studied by magnetic tweezers [Abstract]

BibTeX | RIS | DOI

Sebastian Doniach und Jan Lipfert
Use of small angle X-ray scattering (SAXS) to characterize conformational states of functional RNAs

PDF | BibTeX | RIS | DOI

2008

Vincent B. Chu, Yu Bai, Jan Lipfert, Daniel Herschlag und Sebastian Doniach
A repulsive field: advances in the electrostatics of the ion atmosphere

BibTeX | RIS | DOI

Yu Bai, Vincent B. Chu, Jan Lipfert, Vijay S. Pande, Daniel Herschlag und Sebastian Doniach
Critical assessment of nucleic acid electrostatics via experimental and computational investigation of an unfolded state ensemble

BibTeX | RIS | DOI

Benjamin J. Spink, Sivaraj Sivaramakrishnan, Jan Lipfert, Sebastian Doniach und James A. Spudich
Long single α-helical tail domains bridge the gap between structure and function of myosin VI

BibTeX | RIS | DOI

Jan Lipfert, Jonathan Ouellet, David G. Norman, Sebastian Doniach und David M. J. Lilley
The complete VS ribozyme in solution studied by small-angle x-ray scattering

BibTeX | RIS | DOI

2007

Jan Lipfert
A tandem aptamer riboswitch from vibrio cholerae requires specific divalent ions for glycine binding [Poster abstract]

BibTeX | RIS

Jan Lipfert, Linda Columbus, Vincent B. Chu und Sebastian Doniach
Analysis of small-angle X-ray scattering data of protein–detergent complexes by singular value decomposition

PDF | BibTeX | RIS | DOI

Vincent B. Chu, Yu Bai, Jan Lipfert, Daniel Herschlag und Sebastian Doniach
Evaluation of ion binding to DNA duplexes using a size-modified Poisson-Boltzmann theory

BibTeX | RIS | DOI

Jan Lipfert, Vincent B. Chu, Yu Bai, Daniel Herschlag und Sebastian Doniach
Low-resolution models for nucleic acids from small-angle X-ray scattering with applications to electrostatic modeling

PDF | BibTeX | RIS | DOI

Jan Lipfert, Vincent B. Chu, Yu Bai, Jonathan Ouellet, David M. J. Lilley, Daniel Herschlag und Sebastian Doniach
Modeling RNA low resolution structure and thermodynamics from small-angle X-ray scattering [Abstract]

BibTeX | RIS

Yu Bai, Max Greenfeld, Kevin J. Travers, Vincent B. Chu, Jan Lipfert, Sebastian Doniach und Daniel Herschlag
Quantitative and comprehensive decomposition of the ion atmosphere around nucleic acids

BibTeX | RIS | DOI

Jan Lipfert, Linda Columbus, Vincent B. Chu, Scott A. Lesley und Sebastian Doniach
Size and shape of detergent micelles determined by small-angle X-ray scattering

BibTeX | RIS | DOI

Jan Lipfert
Small-angle X-ray scattering of RNA, proteins, and membrane protein-detergent complexes

BibTeX | RIS

Dissertation, Stanford University, 2007

Jan Lipfert und Sebastian Doniach
Small-angle x-ray scattering from RNA, proteins, and protein complexes

BibTeX | RIS | DOI

Jan Lipfert, Rhiju Das, Vincent B. Chu, Madhuri Kudaravalli, Nathan Boyd, Daniel Herschlag und Sebastian Doniach
Structural transitions and thermodynamics of a glycine-dependent riboswitch from Vibrio cholerae

BibTeX | RIS | DOI

Timothy J. Wilson, Jonathan Oullet, Jan Lipfert, Aileen McLeod und David M. J. Lilley
The structure and catalytic mechanism of the VS ribozyme [Abstract]

BibTeX | RIS

2006

Linda Columbus, Jan Lipfert, Heath Klock, Ian Millett, Sebastian Doniach und Scott A. Lesley
Expression, purification, and characterization of Thermotoga maritima membrane proteins for structure determination

BibTeX | RIS | DOI

Gautam Dantas, Alexander L. Watters, Bradley M. Lunde, Ziad M. Eletr, Nancy G. Isern, Toby Roseman, Jan Lipfert, Sebastian Doniach, Martin Tompa, Brian Kuhlman, Barry L. Stoddard, Gabriele Varani und David Baker
Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution

BibTeX | RIS | DOI

Jan Lipfert, Ian S. Millett, Sönke Seifert und Sebastian Doniach
Sample holder for small-angle x-ray scattering static and flow cell measurements

PDF | BibTeX | RIS | DOI

2005

Jan Lipfert, Joel Franklin, Fang Wu und Sebastian Doniach
Protein misfolding and amyloid formation for the peptide GNNQQNY from yeast prion protein Sup35: simulation by reaction path annealing

BibTeX | RIS | DOI

Bojan Zagrovic, Jan Lipfert, Eric J. Sorin, Ian S. Millett, Wilfred F. van Gunsteren, Sebastian Doniach und Vijay S. Pande
Unusual compactness of a polyproline type II structure

BibTeX | RIS | DOI

Jan Lipfert und S. Donaich
Unzipping the polar zipper: molecular dynamics simulation of force induced beta-amyloid disassembly and implications for future experiments [Abstract]

BibTeX | RIS

2004

Jan Lipfert, Jorge Llano und Leif A. Eriksson
Radiation-induced damage in serine phosphate - insights into a mechanism for direct DNA strand breakage

BibTeX | RIS | DOI

2024

  • Stefanie D. Pritzl, Alptug Ulugöl, Caroline Körösy, Laura Filion, and Jan Lipfert
    Accurate drift-invariant single-molecule force calibration using the Hadamard variance
    Biophys J. 123(22):3964-3976 (2024)

  • Marjolein de Jager, Pauline J. Kolbeck, Willem Vanderlinden, Jan Lipfert, and Laura Filion
    Exploring protein-mediated compaction of DNA by coarse-grained simulations and unsupervised learning
    Biophys J. 123(18):3231-3241 (2024)

  • Yi-Yun Lin, Peter Müller, Evdoxia Karagianni, Nicola Hepp, Felix Mueller-Planitz, Willem Vanderlinden, and Jan Lipfert
    Epigenetic Histone Modifications H3K36me3 and H4K5/8/12/16ac Induce Open Polynucleosome Conformations via Different Mechanisms

    J. Mol. Biol. 436(16):168671 (2024)

  • Hana Dohnalová, Mona Seifert, Eva Matoušková, Misha Klein, Flávia S. Papini, Jan Lipfert, David Dulin, and Filip Lankas
    Temperature-Dependent Twist of Double-Stranded RNA Probed by Magnetic Tweezer Experiments and Molecular Dynamics Simulations
    J. Phys. Chem. B  128(3):664-675 (2024)

  • Aidin Lak, Yihao Wang, Pauline J. Kolbeck, Christoph Pauer, Mohammad Suman Chowdhury, Marco Cassani, Frank Ludwig, Thilo Viereck, Florian Selbach, Philip Tinnefeld, Meinhard Schilling, Tim Liedl, Joe Tavacoli, and Jan Lipfert
    Cooperative dynamics of DNA-grafted magnetic nanoparticles optimize magnetic biosensing and coupling to DNA origami
    Nanoscale 16(15):7678-7689 (2024)

  • Magnus S. Bauer, Sophia Gruber, Adina Hausch, Marcelo C.R. Melo, Priscila S.F.C. Gomes, Thomas Nicolaus, Lukas F. Milles, Hermann E. Gaub, Rafael C. Bernardi, and Jan Lipfert

    Single-molecule force stability of the SARS-CoV-2–ACE2 interface in variants-of-concern

    Nature Nanotechnol. 3:399-405 (2024)

  • Pauline J. Kolbeck, Miloš Tišma, Brian T. Analikwu, Willem Vanderlinden, Cees Dekker, and Jan Lipfert
    Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and single-molecule experiments
    Nucleic Acids Res. 52(1):59-72 (2024) 

     

2023

  • Pauline J. Kolbeck, Dihia Benaoudia, Léa Chazot-Franguiadakis, Gwendoline Delecourt, Jérôme Mathé, Sha Li, Romeo Bonnet, Pascal Martin, Jan Lipfert, Anna Salvetti, Mordjane Boukhet, Véronique Bennevault, Jean-Christophe Lacroix, Philippe Guégan, and Fabien Montel
    Thermally Switchable Nanogate Based on Polymer Phase Transition

    Nano Letters 23:4862-4869 (2023)  [Link]
  • Yi-Yun Lin, Tine Brouns, Pauline J. Kolbeck, Willem Vanderlinden, and Jan Lipfert
    High-yield, ligation-free assembly of DNA constructs with nucleosome positioning sequence repeats for single molecule manipulation assays
    J Biol Chem. 299(7):104874 (2023)  [Link]
  • Pauline J. Kolbeck, Mihir Dass, Irina V. Martynenko, Relinde J.A. van Dijk-Moes, Kelly J.H. Brouwer, Alfons van Blaaderen, Willem Vanderlinden, Tim Liedl, and Jan Lipfert
    A DNA origami fiducial for accurate 3D AFM imaging
    Nano Letters 22:1236-1243 (2023) [Link]

2022

  • Willem Vanderlinden†, Enrico Skoruppa†, Pauline J Kolbeck, Enrico Carlon*, and Jan Lipfert*
    DNA fluctuations reveal the size and dynamics of topological domains
    PNAS Nexus 1(5):pgac268 (2022) (†Authors contributed equally; *Joint corresponding authorship)
    [PDF][Supplementary Information PDF]
  • Sophia Gruber†, Achim Löf†, Adina Hausch, Fabian Kutzki, Res Jöhr, Tobias Obser, Gesa König, Reinhard Schneppenheim, Camilo Aponte-Santamaría, Frauke Gräter, Maria A. Brehm, Martin Benoit*, and Jan Lipfert*
    A conformational transition of the D'D3 domain primes von Willebrand factor for multimerization
    Blood Adv. 6:5198-5209 (2022) (†Authors contributed equally; *Joint corresponding authorship)
    [PDF][Supplementary information PDF]
  • Sergio Cruz-León†, Willem Vanderlinden†, Peter Müller, Tobias Forster, Georgina Staudt, Yi-Yun Lin, Jan Lipfert*, and Nadine Schwierz*
    Twisting DNA by Salt  
    Nucleic Acids Res. 50:5726-5738 (2022) (†Authors contributed equally; *Joint corresponding authorship)
    [PDF][Supplementary information PDF]
  • Magnus Sebastian Bauer†, Sophia Gruber†, Adina Hausch, Priscila S.F.C. Gomes, Lukas F. Milles, Thomas Nicolaus, Leonard C. Schendel, Pilar López-Navajas, Erik Procko, Daniel Lietha, Marcelo C.R. Melo, Rafael C Bernardi, Hermann E. Gaub, and Jan Lipfert
    A Tethered Ligand Assay to Probe SARS-CoV-2:ACE2 Interactions
    Proc. Natl. Acad. Sci. U.S.A. 119:e2114397119 (†Authors contributed equally)
    [PDF][Supplementary information PDF]
  • Sebastian F Konrad, Willem Vanderlinden, Jan Lipfert
    Quantifying epigenetic modulation of nucleosome breathing by high-throughput AFM imaging
    Biophys. J. 121:841-851 (2022)
    [PDF][Supplementary information PDF]

2021

  • Sebastian F Konrad, Willem Vanderlinden, Jan Lipfert
    A High-throughput Pipeline to Determine DNA and Nucleosome Conformations by AFM Imaging
    Bio Protoc. 11(19):e4180 (2021)
  • Willem Vanderlinden and Jan Lipfert
    A Gentle Twist on DNA
    Physics 14(98):1-3 (2021)
    [PDF]
  • Pauline J. Kolbeck, Willem Vanderlinden*, Gerd Gemmecker, Christian Gebhardt, Martin Lehmann, Aidin Lak, Thomas Nicolaus, Thorben Cordes, and Jan Lipfert*
    Molecular structure, DNA binding mode, photophysical properties and recommendations for use of SYBR Gold
    Nucleic Acids Res. 49:5143–5158 (2021) (*Joint corresponding authorship)
    [PDF][Supplementary information PDF][Correction]
  • Ann-Kathrin Reichenwallner, Esma Vurmaz, Kristina Battis, Laura Handl, Helin Üstün, Tivadar Mach, Gabriele Hörnig, Jan Lipfert,  and Lukas Richter
    Optical Investigation of Individual Red Blood Cells for Determining Cell Count and Cellular Hemoglobin Concentration in a Microfluidic Channel
    Micromachines 12(4):358 (2021)
    [Link]
  • Sebastian F. Konrad, Willem Vanderlinden, Wout Frederickx, Tine Brouns, Bjoern Menze, Steven De Feyter, and Jan Lipfert
    High-throughput AFM analysis reveals unwrapping pathways of H3 and CENP-A nucleosomes
    Nanoscale 13(10):5435-5447 (2021)
    [PDF][Supplementary information PDF]

2020

  • Magnus S. Bauer, Sophia Gruber, Lukas F. Milles, Thomas Nicolaus, Leonard C. Schendel, Hermann E. Gaub, and Jan Lipfert
    A Tethered Ligand Assay to Probe the SARS-CoV-2 ACE2 Interaction under Constant Force
    [bioRxiv preprint]
  • Helena Lipfert and Jan Lipfert
    Der Elektronikbaukasten Kosmos Easy Elektro – Start (Review, in German)
    Physik in unserer Zeit 51:307 (2020)
    [PDF]
  • Sophia Gruber†, Achim Löf†, Steffen M. Sedlak†, Martin Benoit, Hermann E. Gaub, and Jan Lipfert
    Designed Anchoring Geometries Determine Lifetimes of Biotin-Streptavidin Bonds under Constant Load and Enable Ultra-Stable Coupling
    Nanoscale 12:21131-21137 (2020) (†Authors contributed equally)
    [PDF][Supplementary information PDF]
  • Thomas Zettl, Xuesong Shi, Steve Bonilla, Steffen M. Sedlak, Jan Lipfert*, and Daniel Herschlag*
    The Structural Ensemble of a Holliday Junction Determined by X-Ray Scattering Interference
    Nucleic Acids Res. 48:8090-8098 (2020) (*Joint corresponding authorship)
    [PDF][Supplementary information PDF]
  • Willem Vanderlinden, Pauline J. Kolbeck, Franziska Kriegel, Philipp U. Walker, and Jan Lipfert
    A benchmark data set for the mechanical properties of double-stranded DNA and RNA under torsional constraint
    Data in Brief 30:105404 (2020)
    [PDF]
  • Hana Dohnalová, Tomáš Dršata, Jiří Šponer, Martin Zacharias, Jan Lipfert*, Filip Lankaš*
    Compensatory Mechanisms in Temperature Dependence of DNA Double Helical Structure: Bending and Elongation
    Journal of Chemical Theory and Computation, doi.org/10.1021/acs.jctc.0c00037 (2020)  (*Joint corresponding authorship)
    [PDF][Supplementary information PDF]
  • Katharina Ott, Linda Martini, Jan Lipfert, and Ulrich Gerland
    Dynamics of the Buckling Transition in Double-Stranded DNA and RNA
    Biophys. J. 118:1690–1701 (2020)
    [PDF]
  • Shan Zhao, Mihail Ivilinov Todorov, Ruiyao Cai, Rami AI -Maskari, Hanno Steinke, Elisabeth Kemter, Hongcheng Mai, Zhouyi Rong, Martin Warmer, Karen Stanic, Oliver Schoppe, Johannes Christian Paetzold, Benno Gesierich, Milagros N. Wong, Tobias B. Huber, Marco Duering, Oliver Thomas Bruns, Bjoern Menze, Jan Lipfert, Victor G. Puelles, Eckhard Wolf, Ingo Bechmann, and Ali Ertürk
    Cellular and Molecular Probing of Intact Transparent Human Organs
    Cell 180:796–812 (2020)
    [PDF]
  • Aidin Lak, Tamara Kahmann, Simon J. Schaper, Jaroslava Obel, Frank Ludwig, Peter Müller-Buschbaum, and Jan Lipfert
    The Dissociation Rate of Acetylacetonate Ligands Governs the Size of Ferrimagnetic Zinc Ferrite Nanocubes
    ACS Appl Mater Interfaces 12:217-226 (2020)
    [PDF][Supplementary information PDF]

2019

  • Abhijeet Pataskar, Willem Vanderlinden, Johannes Emmerig, Aditi Singh, Jan Lipfert, and Vijay K. Tiwari
    Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features
    iScience 21:638–649 (2019)
    [PDF][Supplementary information PDF]
  • Willem Vanderlinden, Tine Brouns, Philipp U. Walker, Pauline Kolbeck, Lukas Milles, Wolfgang Ott, Philipp Nickels, Zeger Debyser, and Jan Lipfert
    The Free Energy Landscape of Retroviral Integration
    Nature Communications 10:4738 (2019)
    [PDF][Supplementary information PDF]
  • Achim Löf, Philipp U. Walker, Steffen M. Sedlak, Sophia Gruber, Tobias Obser, Maria A. Brehm, Martin Benoit, Jan Lipfert
    Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor
    Proc. Natl. Acad. Sci. U.S.A. 116:18798-18807 (2019)
    [PDF][Supplementary information PDF]
  • Willem Vanderlinden, Pauline J. Kolbeck, Wout Frederickx, Sebastian F. Konrad, Thomas Nicolaus, Carola Lampe, Alexander S. Urban, Cécile Moucheronc, and Jan Lipfert
    Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA
    Chem. Commun. 55(60):8764-8767 (2019)
    [Cover][PDF][Supplementary information PDF]
  • Jan Lipfert
    Halliday Physik (book review, in German)
    Physik in unserer Zeit 50:48 (2019)
    [PDF]

2018

  • Tine Brouns, Herlinde De Keersmaecker, Sebastian Konrad, Noriyuki Kodera, Toshio Ando, Jan Lipfert*, Steven De Feyter*, Willem Vanderlinden*
    Free Energy Landscape and Dynamics of Supercoiled DNA by High-Speed Atomic Force Microscopy
    ACS Nano 12:11907−11916 (2018) (*Joint corresponding authorship)
    [PDF][Supplementary information PDF]
  • Miloš T. Ivanović, Linda K. Bruetzel, Roman Shevchuk, Jan Lipfert, and Jochen S. Hub
    Quantifying the influence of the ion cloud on SAXS profiles of charged proteins
    Phys. Chem. Chem. Phys., 20(41):26351-26361 (2018)
    [PDF][Supplementary information PDF
  • Philipp U. Walker, Willem Vanderlinden, and Jan Lipfert
    Dynamics and Energy Landscape of DNA Plectoneme Nucleation
    Phys. Rev. E 0424121-13 (2018)
    [PDF][Supplementary information PDF]
  • Franziska Kriegel, Christian Matek, Tomas Drsata, Klara Kulenkampff, Sophie Tschirpke, Martin Zacharias, Filip Lankas*, and Jan Lipfert*
    The Temperature Dependence of the Helical Twist of DNA
    Nucleic Acids Res. 46(15):7998-8009 (2018) (*Joint corresponding authorship)
    [PDF][Supplementary information PDF
  • Thomas Zettl, Rebecca S. Mathew, Xuesong Shi, Sebastian Doniach, Daniel Herschlag, Pehr A.B. Harbury, Jan Lipfert
    Gold Nanocrystal Labels Provide a Sequence-to-3D Structure Map in SAXS Reconstructions
    Science Advances 4:eaar4418 (2018)
    [PDF][Supplementary information PDF
  • Thomas Zettl, Rhiju Das, Pehr A.B. Harbury*, Daniel Herschlag*, Jan Lipfert*, Rebecca S. Mathew, Xuesong Shi
    Recording and Analyzing Nucleic Acid Distance Distributions with X-ray Scattering Interferometry (XSI)
    Current Protocols e54 (2018) (*Joint corresponding authorship)
    [PDF
  • Franziska Kriegel, Willem Vanderlinden, Thomas Nicolaus, Angelika Kardinal, and Jan Lipfert
    Measuring Single-Molecule Twist and Torque in Multiplexed Magnetic Tweezers
    Methods Mol. Biol. 1814:75-98 (2018)
    [PDF
  • Linda K. Bruetzel, Philipp Walker, Thomas Gerling, Hendrik Dietz, and Jan Lipfert
    Time-Resolved Small-Angle X-Ray Scattering Reveals Millisecond Transitions of a DNA Origami Switch
    Nano Letters 18:2672-2676 (2018)
    [PDF][Supplementary information PDF]
  • Maarten M. van Oene†, Seungkyu Ha†, Tessa Jager, Mina Lee, Francesco Pedaci, Jan Lipfert*, and Nynke H. Dekker*
    Quantifying the Precision of Single-Molecule Torque and Twist Measurements Using Allan Variance
    Biophys. J. 114:1970–1979 (2018) (†Authors contributed equally; *Joint corresponding authorship)
    [Article with supplementary information PDF
  • Miloš T. Ivanović, Linda K. Bruetzel, Jan Lipfert*, and Jochen S. Hub*
    Temperature-dependent atomic models of detergent micelles refined against small-angle X-ray scattering data
    Angewandte Chemie 57 (2018) (*Joint corresponding authorship)
    [PDF][Supplementary information PDF
  • Nadine Harrer†, Christina E.M. Schindler†, Linda K. Bruetzel, Ignasi Forné, Johanna Ludwigsen, Axel Imhof, Martin Zacharias, Jan Lipfert*, Felix Mueller-Planitz*
    Structural architecture of the nucleosome remodeler ISWI determined from cross-linking, mass spectrometry, SAXS and modeling
    Structure 26:1-13 (2018) (†Authors contributed equally; *Joint corresponding authorship)
    [PDF][Supplementary information PDF

2017

  • Sabrina Simoncelli*, Samuel Johnson, Franziska Kriegel, Jan Lipfert*, and Jochen Feldmann
    Stretching and heating single DNA molecules with optically trapped gold-silica Janus particles
    ACS Photonics 4:2843–2851 (*Joint corresponding authorship)
    [PDF][Supplementary information PDF
  • Stefanos K. Nomidis, Franziska Kriegel, Willem Vanderlinden, Jan Lipfert, and Enrico Carlon
    Twist-Bend Coupling and the Torsional Response of Double-Stranded DNA
    Phys. Rev. Lett. 118:2178011-6 (2017)
    [PDF][Supplementary information PDF]  
  • Franziska Kriegel, Niklas Ermann, Ruaridh Forbes, David Dulin, Nynke H. Dekker, and Jan Lipfert
    Probing the salt dependence of the torsional stiffness of DNA by multiplexed magnetic torque tweezers
    Nucleic Acids Res. 45:5920-5929 (2017)
    [PDF][Supplementary information PDF
  •  
  • Steffen M. Sedlak, Linda K. Bruetzel, and Jan Lipfert
    Quantitative Evaluation of Statistical Errors in Small-Angle X-Ray Scattering Measurements
    J. Appl.Cryst. 50:621–630 (2017)
    [PDF][Supplementary information PDF
  • Maarten M. van Oene, Laura E. Dickinson, Bronwen Cross, Francesco Pedaci, Jan Lipfert, and Nynke H. Dekker
    Applying torque to the Escherichia coli flagellar motor using magnetic tweezers
    Scientific Reports 7:43285 (2017)
    [PDF][Supplementary information PDF
  • Franziska Kriegel, Niklas Ermann, and Jan Lipfert
    Probing the Mechanical Properties, Conformational Changes, and Interactions of Nucleic Acids with Magnetic Tweezers
    J. Struct. Biol. 197:26-36 (2017) 
    [PDF]

2016 

  • Linda K. Bruetzel, Thomas Gerling, Steffen M. Sedlak, Philipp U. Walker, Wenjun Zheng, Hendrik Dietz, and Jan Lipfert
    Conformational Changes and Flexibility of DNA Devices Observed by Small-Angle X-Ray Scattering
    Nano Letters 16:4871-9 (2016)
    [PDF][Supplementary information PDF
  • Thomas Zettl, Rebecca S. Mathew, Sönke Seifert, Sebastian Doniach, Pehr A.B. Harbury, and Jan Lipfert
    Absolute Intra-Molecular Distance Measurements with Ångström-Resolution using Anomalous Small-Angle X-ray Scattering 
    Nano Letters 16:5353-7 (2016)
    [Cover][PDF][Supplementary information PDF] 
  • Jochen P. Müller, Achim Löf, Salomé Mielke, Tobias Obser,  Linda Bruetzel, Willem Vanderlinden, Jan Lipfert, Reinhard Schneppenheim, and Martin Benoit
    pH-Dependent Interactions in Dimers Govern Mechanics and Structure of von Willebrand Factor
    Biophys. J. 111:321-322 (2016)
    [PDF with Supplement
  • Linda K. Bruetzel, Stefan Fischer, Annalena Salditt, Steffen Sedlak, Bert Nickel, and Jan Lipfert
    A Mo-Anode-Based In-House Source for Small-Angle X-Ray Scattering Measurements of Biological Macromolecules
    Rev. Sci. Instrum. 87:025103 (2016)
    [PDF
  • Jochen P. Müller, Salomé Mielke, Achim Löf, Tobias Obser, Christof Beer, Linda Bruetzel, Diana A. Pippig, Willem Vanderlinden, Jan Lipfert, Reinhard Schneppenheim, and Martin Benoit
    Force sensing by the vascular protein von Willebrand Factor is tuned by a strong intermonomer interaction
    Proc. Natl. Acad. Sci. U.S.A. 113:1208-13 (2016)
    [PDF with Supplement

2015  

  • Magdalena Gebala, George M. Giambasu, Jan Lipfert, Namita Bisaria, Steve Bonilla, Guangchao Li, Darrin M. York, and Daniel Herschlag
    Cation-Anion Interactions within the Nucleic Acid Ion Atmosphere Revealed by Ion Counting Studies
    J. Am. Chem. Soc. 137:14705-15 (2015)
    [PDF][Supplementary information PDF
  • David Dulin, Thijs Cui, Jelmer Cnossen, Margreet W. Docter, Jan Lipfert, and Nynke H. Dekker
    High Spatiotemporal Resolution Magnetic Tweezers for Single-Molecule Force Spectroscopy: Calibration and Applications to DNA Dynamics
    Biophys. J. 109:2113–2125 (2015)
    [PDF
  • Korbinian Liebl, Tomas Drsata, Filip Lankas, Jan Lipfert, and Martin Zacharias
    Explaining the striking difference in twist-stretch coupling between DNA and RNA: A comparative molecular dynamics analysis
    Nucleic Acids Res. 43:10143-56 (2015)
    [PDF][Supplementary information PDF
  • Jan Lipfert* and Nynke H. Dekker*
    De RNA-helix lijkt niet altijd op die van DNA (in Dutch)
    Nederlands Tijdschrift voor Natuurkunde 6:224-227 (2015) (*Joint corresponding authorship)
    [PDF] 
  • Maarten M. van Oene, Laura E. Dickinson, Francesco Pedaci, Mariana Köber, David Dulin, Jacob W.J. Kerssemakers, Jan Lipfert*, and Nynke H. Dekker*
    Biological Magnetometry: Torque on Superparamagnetic Beads in Magnetic Fields
    Phys. Rev. Lett. 114:218301-6 (2015) (*Joint corresponding authorship)
    [PDF][Supplementary information PDF] 
  • Rifka Vlijm, Mina Lee, Jan Lipfert, Alexandra Lusser, Cees Dekker, and Nynke H. Dekker
    Nucleosome assembly dynamics involve spontaneous fluctuations in the handedness of tetrasomes
    Cell Reports 10:1-10 (2015)
    [PDF]
  • Jan Lipfert, Maarten M. van Oene, Mina Lee, Francesco Pedaci, and Nynke H. Dekker
    Torque spectroscopy for the study of rotary motion in biological systems
    Chemical Reviews 115:1449-74 (2015)
    [Cover][PDF] 

2014

  • Zhongbo Yu, David Dulin, Jelmer Cnossen, Mariana Köber, Maarten van Oene, Orkide Ordu, Bojk Berghuis, Jan Lipfert, and Nynke H. Dekker
    A force calibration standard for magnetic tweezers
    Rev. Sci. Instrum. 85:123114 (2014)
    [PDF] 
  • Jan Lipfert, Gary M. Skinner, Johannes Keegstra, Toivo Hensgens, Tessa Jager, Mariana Köber, Zhongbo Yu, Serge Donkers, Fang-Chieh Chou, Rhiju Das, and Nynke H. Dekker
    Double-Stranded RNA under Force and Torque: Similarities to and Striking Differences from Double- Stranded DNA
    Proc. Natl. Acad. Sci. U.S.A. 111:15408-13 (2014)
    [PDF][Supplementary information PDF] 
  • Ryan Oliver, Jan Lipfert, Daniel Fox, Ryan Lo, Justin Kim, Sebastian Doniach, and Linda Columbus
    Tuning micelle dimensions and properties with binary surfactant mixtures
    Langmuir 30:13353-61 (2014)
    [PDF][Supplementary information PDF] 
  • Fang-Chieh Chou, Jan Lipfert, and Rhiju Das
    Blind predictions of DNA and RNA tweezers experiments with force and torque
    PLoS Comput. Biol. 10:e1003756 (2014)
    [PDF] 
  • Jan Lipfert, Mina Lee, Orkide Ordu, Jacob W.J. Kerssemakers, and Nynke H. Dekker
    Magnetic tweezers for the measurement of twist and torque
    J. Vis. Exp. 19:87 (2014)
    [PDF] 
  • Willem Vanderlinden, Jan Lipfert, Jonas Demeulemeester, Zeger Debyser, and Steven De Feyter
    Structure, mechanics, and binding mode heterogeneity of LEDGF/p75-DNA nucleoprotein complexes as revealed by scanning force microscopy
    Nanoscale 6:4611-9 (2014)
    [PDF][Supplementary information PDF] 
  • Jan Lipfert, Sebastian Doniach, Rhiju Das, and Daniel Herschlag
    Understanding Nucleic Acid-Ion Interactions
    Annual Review of Biochemistry 83:813-41 (2014)
    [PDF] 

2013

  • Mina Lee, Jan Lipfert, Humberto Sanchez, Claire Wyman, and Nynke H. Dekker
    Structural and torsional properties of the RAD51-dsDNA nucleoprotein filaments
    Nucleic Acids Res. 41:7023-30 (2013)
    [Cover][PDF][Supplementary information PDF] 
  • Ryan C. Oliver, Jan Lipfert, Daniel A. Fox, Ryan H. Lo, Sebastian Doniach, and Linda Columbus
    Dependence of micelle size and shape on detergent alkyl chain length and head group
    PLOS ONE 8:62488 (2013)
    [PDF] 
  • David Dulin, Jan Lipfert, M. Charl Moolman, and Nynke H. Dekker
    Studying genomic processes at the single-molecule level: introducing the tools and applications
    Nature Reviews Genetics 14:9-22 (2013)
    [Cover][PDF]

2012

  • Adelene Y.L. Sim, Jan Lipfert, Daniel Herschlag, and Sebastian Doniach
    Salt dependence of the radius of gyration and flexibility of single-stranded DNA in solution probed by small-angle x-ray scattering
    Phys. Rev. E 86:021901 (2012)
    [PDF][Supplementary information PDF]
  • Xander Janssen†, Jan Lipfert†, Tessa Jager, Renier Daudey, and Nynke H. Dekker
    Electromagnetic torque tweezers: a versatile approach for measurement of single-molecule twist and torque
    Nano Lett. 12:3634-9 (2012) (†Authors contributed equally)
    [PDF][Supplementary information PDF] 
  • Sebastian Doniach and Jan Lipfert
    Small and wide angle X-ray scattering of biological macromolecules and their complexes in solution
    Comprehensive Biophysics 1:376-397 (2012)
    [PDF] 

2011

  • Jan Lipfert†, Jacob W.J. Kerssemakers†, Maylon Rojer, and Nynke H. Dekker
    A method to track rotational motion for use in single-molecule biophysics
    Rev. Sci. Instrum. 82:103707 (2011) (†Authors contributed equally)
    [PDF]
  • Jan Lipfert†, Matthew Wiggin†, Jacob W.J. Kerssemakers, Francesco Pedaci, and Nynke H. Dekker
    Freely orbiting magnetic tweezers to directly monitor changes in the twist of nucleic acids 
    Nature Communications 2:439 (2011) (†Authors contributed equally)
    [PDF][Supplementary information PDF]
    See also:
    Corrigendum: Freely orbiting magnetic tweezers to directly monitor changes in the twist of nucleic acids
    Nature Communications 6:7192 (2015)
    [PDF] 

2010

  • Jan Lipfert, Jacob W.J. Kerssemakers, Tessa Jager, and Nynke H. Dekker
    Magnetic torque tweezers: measuring torsional stiffness in DNA and RecA-DNA filaments
    Nature Methods 7:977-80 (2010)
    [PDF][Supplementary information PDF]
  • Jan Lipfert, Sven Klijnhout, and Nynke H. Dekker
    Torsional sensing of small-molecule binding using magnetic tweezers 
    Nucleic Acids Res. 38:7122-32 (2010)
    [PDF] 
  • Aartjan J. teVelthuis, Jacob W.J. Kerssemakers, Jan Lipfert, and Nynke H. Dekker
    Quantitative guidelines for force calibration through spectral analysis of magnetic tweezers data
    Biophys. J. 99:1292-302 (2010)
    [PDF] 
  • Jan Lipfert†, Adelene Y.L. Sim†, Daniel Herschlag, and Sebastian Doniach
    Dissecting electrostatic screening, specific ion binding, and ligand binding in an energetic model for glycine riboswitch folding
    RNA 16:708-19 (2010) (†Authors contributed equally)
    [PDF] 
  • Mona Ali, Jan Lipfert, Sönke Seifert, Daniel Herschlag, and Sebastian Doniach
    The ligand-free state of the TPP riboswitch: a partially folded RNA structure
    J. Mol. Biol. 396:153-65 (2010)
    [PDF] 
  • S. Menze, C. Menze, J. Lipfert, B. Menze, and G. Harsch
    Der Vorfahr aus der Bronzezeit (in German)
    Praxis der Naturwissenschaften - Chemie in der Schule 5:6 (2010) 

2009

  • Vincent B. Chu, Jan Lipfert, Yu Bai, Vijay S. Pande, Sebastian Doniach, and Daniel Herschlag
    Do conformational biases of simple helical junctions influence RNA folding stability and specificity?
    RNA 15:2195-205 (2009)
    [PDF]
  • Jan Lipfert, Xiaomin Hao, and Nynke H. Dekker
    Quantitative modeling and optimization of magnetic tweezers
    Biophys. J. 96:5040-9 (2009)
    [PDF] [Supplementary information PDF] [Example calculations]
  • Jan Lipfert, Daniel A. Koster, Igor D. Vilfan, Susanne Hage, and Nynke H. Dekker
    Single-molecule magnetic tweezers studies of type IB topoisomerases
    Methods Mol. Biol. 582:71-89 (2009)
    [PDF] 
  • Igor D. Vilfan, Jan Lipfert, Daniel A. Koster, Serge G. Lemay, and Nynke H. Dekker
    Magnetic tweezers for single-molecule experiments
    Handbook of Single-Molecule Biophysics, Springer (2009)
    [PDF] 
  • Linda Columbus, Jan Lipfert, K. Jambunathan, Daniel A. Fox, Adelene Y.L. Sim, Sebastian Doniach, and Scott A. Lesley
    Mixing and matching detergents for membrane protein NMR structure determination
    J. Am. Chem. Soc. 131:7320-6 (2009)
    [PDF] [Supplementary information PDF] 
  • Jan Lipfert, Daniel Herschlag, and Sebastian Doniach
    Riboswitch conformations revealed by small-angle X-ray scattering
    Methods Mol. Biol. 540:141-59 (2009)
    [PDF] 
  • Sebastian Doniach and Jan Lipfert
    Use of small angle X-ray scattering (SAXS) to characterize conformational states of functional RNAs
    Methods Enzymol. 469:237-51 (2009)
    [PDF] 

2008

  • Vincent B. Chu, Yu Bai, Jan Lipfert, Daniel Herschlag, and Sebastian Doniach
    A repulsive field: advances in the electrostatics of the ion atmosphere
    Curr. Opin. Chem. Biol. 12:619-25 (2008)
    [PDF] 
  • JanLipfert†,JonathanOuellet†,DavidG.Norman,SebastianDoniach,andDavidM.J.Lilley
    The complete VS ribozyme in solution studied by small-angle X-ray scattering
    Structure 16:1357-67 (2008) (†Authors contributed equally)
    [PDF] [Supplementary information PDF] 
  • Yu Bai, Vincent B. Chu, Jan Lipfert, Vijay S. Pande, Daniel Herschlag, and Sebastian Doniach
    Critical assessment of nucleic acid electrostatics via experimental and computational investigation of an unfolded state ensemble
    J. Am. Chem. Soc. 130:12334-41 (2008)
    [PDF] [Supplementary information PDF] 
  • Benjamin J. Spink, Sivaraj Sivaramakrishnan, Jan Lipfert, Sebastian Doniach, and James A. Spudich
    Long single alpha-helical tail domains bridge the gap between structure and function of myosin VI
    Nature Struct. Mol. Biol. 15:591-7 (2008)
    [PDF] [Supplementary information PDF] 

2007

  • Yu Bai, Kevin Travers, Vincent B. Chu, Jan Lipfert, Daniel Herschlag, and Sebastian Doniach
    Quantitative and comprehensive decomposition of the ion atmosphere around nucleic acids
    J. Am. Chem. Soc. 129:14981-8 (2007)
    [PDF] [Supplementary information PDF] 
  • Jan Lipfert, Linda Columbus, Vincent B. Chu, Scott A. Lesley, and Sebastian Doniach
    Size and shape of detergent micelles determined by small-angle X-ray scattering
    J. Phys. Chem. B. 111:12427-38 (2007)
    [PDF] 
  • Vincent B. Chu, Yu Bai, Jan Lipfert, Daniel Herschlag, and Sebastian Doniach
    Evaluation of ion binding to DNA duplexes using a size-modified Poisson-Boltzmann theory
    Biophys. J. 93:3202-9 (2007)
    [PDF] 
  • Jan Lipfert and Sebastian Doniach
    Small-angle X-ray scattering from RNA, proteins, and protein complexes
    Annual Reviews Biophys. Biomol. Struct. 36:307-27 (2007)
    [PDF] 
  • Jan Lipfert, Rhiju Das, Vincent B. Chu, Madhuri Kudaravalli, Nathan Boyd, Daniel Herschlag, and Sebastian Doniach
    Structural transitions and thermodynamics of a glycine-dependent riboswitch from Vibrio cholerae
    J. Mol. Biol. 365:1393-406 (2007)
    [PDF] [Supplementary information PDF] 
  • Jan Lipfert, Vincent B. Chu, Yu Bai, Daniel Herschlag, and Sebastian Doniach
    Low resolution models for nucleic acids from small-angle X-ray scattering with applications to electrostatic modeling
    J. Appl. Cryst. 40:235-239 (2007)
    [PDF] 
  • Jan Lipfert, Linda Columbus, Vincent B. Chu, and Sebastian Doniach
    Analysis of small-angle X-ray scattering data of protein-detergent complexes by singular value decomposition
    J. Appl. Cryst. 40:229-234 (2007)
    [PDF]
     

2006

  • Gautam Dantas, Alexander L. Watters, Bradley Lunde, Ziad Eletr, Nancy Isern, Jan Lipfert, Sebastian Doniach, Brian Kuhlman, Barry L. Stoddard, Gabriele Varani, and David Baker
    Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution
    J. Mol. Biol. 362:1004-1024 (2006)
    [PDF] [Supplementary information 1] [Supplementary information 2]
  • Jan Lipfert, Ian S. Millett, Sönke Seifert, and Sebastian Doniach
    A sample holder for small-angle X-ray scattering static and flow cell measurements
    Rev. Sci. Instrum. 77:046108 (2006)
    [PDF] [Supplementary information PDF] 
  • Linda Columbus, Jan Lipfert, Heath Klock, Ian S. Millett, Sebastian Doniach, and Scott Lesley
    Expression, purification, and characterization of Thermotoga maritima membrane proteins for structure determination 
    Protein Sci. 15:1-15 (2006)

    [PDF] [Supplementary information PDF] 

2005

  • Bojan Zagrovic, Jan Lipfert, Erik J. Sorin, Ian S. Millett, Wilfred F. van Gunsteren, Sebastian Doniach, and Vijay S. Pande
    Unusual compactness of a polyproline type II structure
    Proc. Natl. Acad. Sci. U.S.A. 102:11698-11703 (2005)
    [PDF]
  • Jan Lipfert, Joel Franklin, Fang Wu, and Sebastian Doniach
    Protein misfolding and amyloid formation for the peptide GNNQQNY from yeast prion protein Sup35: simulation by reaction path annealing
    J. Mol. Biol. 349:648-658 (2005)
    [PDF] [Supplementary information PDF] 

2004

  • Jan Lipfert, Jorge Llano, and Leif A. Eriksson
    Radiation-Induced Damage in Serine Phosphate - Insights into a Mechanism for Direct DNA Strand Breakage
    J. Phys. Chem. B 108:8036-8042 (2004)
    [PDF]

 

 

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