Anatomy and Cell Biology
What content do we teach? Why do we rely on body donations? What research approaches are we interested in? You can find an overview of these topics on our website.
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Super-resolution microscopy now also in Augsburg
With a STED microscope, model STEDyCON from Abberior Instruments, we are launching imaging with nanoscale resolution.
For cooperation please contact Prof. Dr. Katrin Willig.
News
Origin of phagocytes in the vitreous body of the eye clarified
Hope for diabetic retinopathy
A team led by Augsburg cell biologist and anatomist Prof. Dr. Peter Wieghofer has shown that macrophages develop in the vitreous body of the eye during the embryonic stage. Until now, it was assumed that they regularly regenerate from blood cells in the course of life. This finding is important for the treatment of diseases such as diabetic retinopathy. The specialist article on this was recently published in the Journal of Neuroinflammation.
Macrophages, also known as phagocytes, are part of our immune system. They destroy invading pathogens. They are found in the bloodstream and in all organs. A team of researchers at the Faculty of Medicine at the University of Augsburg, led by Prof. Dr. Peter Wieghofer, Professor of Cellular Neuroanatomy, has now gained new insights into these important immune cells in the eye.
They have shown for the first time that macrophages colonize the vitreous body of the mouse eye as early as the embryonic stage. For decades, the state of research was that these so-called hyalocytes - which were already being researched at the time of Rudolf Virchow - regularly regenerate from blood cells. The research results have now been published in the Journal of Neuroinflammation.
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Newsflash publications
"Bitter tastants relax the mouse gallbladder smooth muscle independent of signaling through tuft cells and bitter taste receptors"
In our publication, published in August 2024, we investigated bitter compounds as relaxants for gallbladder smooth muscle. Our findings suggest new ways to treat gallbladder disease caused by abnormal muscle contractions. The study shows that bitter compounds such as dantonium, quinine and dextromethorphan effectively relax gallbladder muscles, independent of the traditional bitter taste receptors and specific cell types previously thought to be relevant. Our results suggest that these compounds act directly on the smooth muscle cells of the gallbladder.
Keshavarz Maryam, Ruppert Anna-Lena, Meiners Mirjam, Poharkar Krupali, Liu Shuya, Mahmoud Wafaa, Winterberg Sarah, Hartmann Petra, Mermer Petra, Perniss Alexander, Offermanns Stefan, Kummer Wolfgang, Schütz Burkhard. https://doi.org/10.1038/s41598-024-69287-6 PDF | BibTeX | RIS | DOI
Current Publications
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Keshavarz Maryam, Ruppert Anna-Lena, Meiners Mirjam, Poharkar Krupali, Liu Shuya, Mahmoud Wafaa, Winterberg Sarah, Hartmann Petra, Mermer Petra, Perniss Alexander, Offermanns Stefan, Kummer Wolfgang, Schütz Burkhard.
Bitter tastants relax the mouse gallbladder smooth muscle independent of signaling through tuft cells and bitter taste receptors.
https://doi.org/10.1038/s41598-024-69287-6
PDF | BibTeX | RIS | DOI |
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Perniss Alexander, Boonen Brett, Tonack Sarah, Thiel Moritz, Poharkar Krupali, Alnouri Mohamad Wessam, Keshavarz Maryam, Papadakis Tamara, Wiegand Silke, Pfeil Uwe, Richter Katrin, Althaus Mike, Oberwinkler Johannes, Schütz Burkhard, Boehm Ulrich, Offermanns Stefan, Leinders-Zufall Trese, Zufall Frank, Kummer Wolfgang.
A succinate/SUCNR1-brush cell defense program in the tracheal epithelium.
https://doi.org/10.1126/sciadv.adg8842
PDF | BibTeX | RIS | DOI |
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Steingruber Laura, Krabichler Florian, Franzmeier Sophie, Wu Wei, Schlegel Jürgen, Koch Marco.
ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms.
https://doi.org/10.1007/s00441-023-03838-7
BibTeX | RIS | DOI |
Locations
Until the completion of the new ITM research building on the medical campus of the University of Augsburg (progress and live camera), the chair is currently using interim research space and offices in the Business Park in Garching near Munich and in the SIGMA Technopark in Augsburg.
Contact
Visiting address administration:
University of Augsburg
Anatomy und Cell Biology
SIGMA-Technopark
Building 10f, 1st floor
Werner-von-Siemens-Straße 6
86159 Augsburg
Mailing address:
University of Augsburg
Faculty of Medicine
Anatomy und Cell Biology
Universitätsstraße 2
89159 Augsburg
Visiting address laboratory Augsburg:
University of Augsburg
Anatomy und Cell Biology
SIGMA-Technopark
Building 10f, 4th floor
Werner-von-Siemens-Straße 6
86159 Augsburg
Visiting address laboratory Garching:
University of Augsburg
Anatomy und Cell Biology
Business Park Garching
Parkring 11-13
85748 Garching near Munich
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