2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2003 | 2002 | 2001

2025

Staffeldt Lisa, Maar Hanna, Beimdiek Julia, Chambers Samuel, Riecken Kristoffer, von Itzstein Mark, Buettner Falk F. R., Everest-Dass Arun, Lange Tobias. Depletion of β1,6-N-acetylglucosaminyltransferase reduces E-selectin binding capacity and migratory potential of human gastrointestinal adenocarcinoma cells. Neoplasia 2025;59:101083. https://doi.org/10.1016/j.neo.2024.101083 PDF | BibTeX | RIS | DOI

2024

Lark Daniel Stephen, Stemmer Kerstin, Ying Wei, Crewe Clair. A brief guide to studying extracellular vesicle function in the context of metabolism. Nature Metabolism 2024;6(10):1839-1841. https://doi.org/10.1038/s42255-024-01112-w BibTeX | RIS | DOI

Dragano Nathalia R. V., Milbank Edward, Haddad-Tóvolli Roberta, Garrido-Gil Pablo, Nóvoa Eva, Fondevilla Marcos F., Capelli Valentina, Zanesco Ariane Maria, Solon Carina, Morari Joseane, Pires Leticia, Estevez-Salguero Ánxela, Beiroa Daniel, González-García Ismael, Barca-Mayo Olga, Diéguez Carlos, Nogueiras Ruben, Labandeira-García José L., Rexen Ulven Elisabeth, Ulven Trond, Claret Marc, Velloso Licio A., López Miguel. Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance. Molecular Metabolism 2024;79:101840. https://doi.org/10.1016/j.molmet.2023.101840 PDF | BibTeX | RIS | DOI

Sharrouf Kinda, Schlosser Christine, Mildenberger Sandra, Fluhrer Regina, Hoeppner Sabine. In vitro cleavage of tumor necrosis factor α (TNFα) by Signal-Peptide-Peptidase-like 2b (SPPL2b) resembles mechanistic principles observed in the cellular context. Chemico-Biological Interactions 2024;111006. https://doi.org/10.1016/j.cbi.2024.111006 BibTeX | RIS | DOI

Krause Christin, Britsemmer Jan H., Bernecker Miriam, Molenaar Anna, Taege Natalie, Geißler Cathleen, Kaehler Meike, Iben Katharina, Judycka Anna, Wagner Jonas, Wolter Stefan, Mann Oliver, Pfluger Paul T., Cascorbi Ingolf, Lehnert Hendrik, Stemmer Kerstin, Schriever Sonja C., Kirchner Henriette. Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity. eLife 2024;12:RP92075. https://doi.org/10.7554/eLife.92075 PDF | BibTeX | RIS | DOI

Karsten Christina B., Büttner Falk F. R., Cajic Samanta, Nehlmeier Inga, Roshani Berit, Klippert Antonina, Sauermann Ulrike, Stolte-Leeb Nicole, Reichl Udo, Gerardy-Schahn Rita, Rapp Erdmann, Stahl-Hennig Christiane, Pöhlmann Stefan. Macrophage- and CD4+ T cell-derived SIV differ in glycosylation, infectivity and neutralization sensitivity. PLoS Pathogens 2024;20(5):e1012190. https://doi.org/10.1371/journal.ppat.1012190 PDF | BibTeX | RIS | DOI

Welsh Joshua A., Goberdhan Deborah C. I., O'Driscoll Lorraine, Buzas Edit I., Blenkiron Cherie, Bussolati Benedetta, Cai Houjian, Di Vizio Dolores, Driedonks Tom A. P., Erdbrügger Uta, Falcon‐Perez Juan M., Fu Qing‐Ling, Hill Andrew F., Lenassi Metka, Lim Sai Kiang, Mahoney Mỹ G., Mohanty Sujata, Möller Andreas, Nieuwland Rienk, Ochiya Takahiro, Sahoo Susmita, Torrecilhas Ana C., Zheng Lei, Zijlstra Andries, Abuelreich Sarah, Bagabas Reem, Bergese Paolo, Bridges Esther M., Brucale Marco, Burger Dylan, Carney Randy P., Cocucci Emanuele, Crescitelli Rossella, Hanser Edveena, Harris Adrian L., Haughey Norman J., Hendrix An, Ivanov Alexander R., Jovanovic‐Talisman Tijana, Kruh‐Garcia Nicole A., Ku'ulei‐Lyn Faustino Vroniqa, Kyburz Diego, Lässer Cecilia, Lennon Kathleen M., Lötvall Jan, Maddox Adam L., Martens‐Uzunova Elena S., Mizenko Rachel R., Newman Lauren A., Ridolfi Andrea, Rohde Eva, Rojalin Tatu, Rowland Andrew, Saftics Andras, Sandau Ursula S., Saugstad Julie A., Shekari Faezeh, Swift Simon, Ter‐Ovanesyan Dmitry, Tosar Juan P., Useckaite Zivile, Valle Francesco, Varga Zoltan, van der Pol Edwin, van Herwijnen Martijn J. C., Wauben Marca H. M., Wehman Ann M., Williams Sarah, Zendrini Andrea, Zimmerman Alan J., Théry Clotilde, Witwer Kenneth W., Kulaj Konxhe. Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. Journal of Extracellular Vesicles 2024;13(2):e12404. https://doi.org/10.1002/jev2.12404 PDF | BibTeX | RIS | DOI For a full list of the MISEV Consortium please visit: https://doi.org/10.1002/jev2.12404 A correction to this article was published under: https://doi.org/10.1002/jev2.12451

Kespohl Birte, Hegele Anna‐Lena, Düsterhöft Stefan, Bakker Hans, Büttner Falk F. R., Hartig Roland, Lokau Juliane, Garbers Christoph. Molecular characterization of the craniosynostosis‐associated interleukin‐11 receptor variants p.T306_S308dup and p.E364_V368del. The FEBS Journal 2024;291(8):1667-1683. https://doi.org/10.1111/febs.17015 PDF | BibTeX | RIS | DOI

Thom Jonas, Roters Nathalie, Schuemann Slavica, Andrée Birgit, Büttner Falk F. R., Hilfiker Andres, Goecke Tobias, Ramm Robert. Reduction in xenogeneic epitopes on porcine endothelial cells by periodate oxidation. Biomedicines 2024;12(7):1470. https://doi.org/10.3390/biomedicines12071470 PDF | BibTeX | RIS | DOI

Maccioni Riccardo, Travisan Caterina, Badman Jack, Zerial Stefania, Wagener Annika, Andrade-Talavera Yuniesky, Picciau Federico, Grassi Caterina, Chen Gefei, Lemoine Laetitia, Fisahn André, Jiang Richeng, Fluhrer Regina, Mentrup Torben, Schröder Bernd, Nilsson Per, Tambaro Simone. Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease. Progress in Neurobiology 2024;102585. https://doi.org/10.1016/j.pneurobio.2024.102585 BibTeX | RIS | DOI

Mentrup Torben, Leinung Nadja, Patel Mehul, Fluhrer Regina, Schröder Bernd. The role of SPP/SPPL intramembrane proteases in membrane protein homeostasis. The FEBS Journal 2024;291(1):25-44. https://doi.org/10.1111/febs.16941 PDF | BibTeX | RIS | DOI

Litschko Christa, Di Domenico Valerio, Schulze Julia, Li Sizhe, Ovchinnikova Olga G., Voskuilen Thijs, Bethe Andrea, Cifuente Javier O., Marina Alberto, Budde Insa, Mast Tim A., Sulewska Małgorzata, Berger Monika, Buettner Falk F. R., Lowary Todd L., Whitfield Chris, Codée Jeroen D. C., Schubert Mario, Guerin Marcelo E., Fiebig Timm. Transition transferases prime bacterial capsule polymerization. Nature Chemical Biology 2024; https://doi.org/10.1038/s41589-024-01664-8 BibTeX | RIS | DOI

2023

Glunk Viktoria, Laber Samantha, Sinnott-Armstrong Nasa, Sobreira Debora R., Strobel Sophie M., Batista Thiago M., Kubitz Phil, Moud Bahareh Nemati, Ebert Hannah, Huang Yi, Brandl Beate, Garbo Garrett, Honecker Julius, Stirling David R., Abdennur Nezar, Calabuig-Navarro Virtu, Skurk Thomas, Ocvirk Soeren, Stemmer Kerstin, Cimini Beth A., Carpenter Anne E., Dankel Simon N., Lindgren Cecilia M., Hauner Hans, Nobrega Marcelo A., Claussnitzer Melina. A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes. Nature Metabolism 2023;5(5):861-879. https://doi.org/10.1038/s42255-023-00807-w BibTeX | RIS | DOI

Kulaj Konxhe, Harger Alexandra, Bauer Michaela, Caliskan Özüm S., Gupta Tilak Kumar, Chiang Dapi Menglin, Milbank Edward, Reber Josefine, Karlas Angelos, Kotzbeck Petra, Sailer David N., Volta Francesco, Lutter Dominik, Prakash Sneha, Merl-Pham Juliane, Ntziachristos Vasilis, Hauner Hans, Pfaffl Michael W., Tschöp Matthias H., Müller Timo D., Hauck Stefanie M., Engel Benjamin D., Gerdes Jantje M., Pfluger Paul T., Krahmer Natalie, Stemmer Kerstin. Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo. Nature Communications 2023;14(1):709. https://doi.org/10.1038/s41467-023-36148-1 PDF | BibTeX | RIS | DOI These authors contributed equally: Konxhe Kulaj, Alexandra Harger, Michaela Bauer, Özüm S. Caliskan

Sulewska Małgorzata, Berger Monika, Damerow Manuela, Schwarzer David, Büttner Falk F. R., Bethe Andrea, Taft Manuel H., Bakker Hans, Mühlenhoff Martina, Gerardy-Schahn Rita, Priem Bernard, Fiebig Timm. Extending the enzymatic toolbox for heparosan polymerization, depolymerization, and detection. Carbohydrate Polymers 2023;319:121182. https://doi.org/10.1016/j.carbpol.2023.121182 BibTeX | RIS | DOI

Stemmer Kerstin, Müller Timo D.. GLP-1-Mimetika — wegweisend zur Behandlung von Diabetes und Adipositas. BIOspektrum 2023;29(2):137-139. https://doi.org/10.1007/s12268-023-1919-6 PDF | BibTeX | RIS | DOI

Smit P., Buehring-Uhle C., Nather C., Negraschus A., Goldmann U., Papadopoulou Alkmini A., Riviere J., Morath V., Henkel E., Bromberger T., Goetze K., Heinz L., Fluhrer Regina, Moser M., Superti-Furga G., Bassermann F., Eichner R.. Inhibiting MGAT1-mediated N-glycosylation reduces proliferation and adhesion of AML cells and increases affinities of anti-SLC3A2 directed immunotherapies [Abstract]. Oncology Research and Treatment 2023;46(Suppl. 5):191. https://doi.org/10.1159/000533576 PDF | BibTeX | RIS | DOI

Moreira Inês B., Rossdam Charlotte, Beimdiek Julia, Vicente Manuel M., Schmitz Jessica, Oberbeck Astrid, Bräsen Jan H., Tezval Hossein, Büttner Falk F. R.. Neolactotetraosylceramide: a novel non-invasive urinary biomarker for bladder cancer. preprint; 2023. https://doi.org/10.1101/2023.08.08.552442 BibTeX | RIS | DOI

Burock Robert, Cajic Samanta, Hennig René, Büttner Falk F. R., Reichl Udo, Rapp Erdmann. Reliable N-glycan analysis–removal of frequently occurring oligosaccharide impurities by enzymatic degradation. Molecules 2023;28(4):1843. https://doi.org/10.3390/molecules28041843 PDF | BibTeX | RIS | DOI

Hoeppner Sabine, Schröder Bernd, Fluhrer Regina. Structure and function of SPP/SPPL proteases: insights from biochemical evidence and predictive modeling. The FEBS Journal 2023;290(23):5456-5474. https://doi.org/10.1111/febs.16968 PDF | BibTeX | RIS | DOI

Rossdam Charlotte, Brand Smilla, Beimdiek Julia, Oberbeck Astrid, Albers Marco Darius, Naujok Ortwin, Büttner Falk F. R.. Targeting the glycan epitope type I N-acetyllactosamine enables immunodepletion of human pluripotent stem cells from early differentiated cells. preprint; 2023. https://doi.org/10.1101/2023.08.30.555456 BibTeX | RIS | DOI

Wedekind Henri, Beimdiek Julia, Rossdam Charlotte, Kats Elina, Wittek Vanessa, Schumann Lisa, Sörensen-Zender Inga, Fenske Arno, Weinhold Birgit, Schmitt Roland, Tiede Andreas, Büttner Falk F. R., Münster-Kühnel Anja, Abeln Markus. The monosialoganglioside GM1a protects against complement attack. Cell Death Discovery 2023;9(1):395. https://doi.org/10.1038/s41420-023-01686-6 PDF | BibTeX | RIS | DOI

2022

Hütte Hermann J., Tiemann Birgit, Shcherbakova Aleksandra, Grote Valerian, Hoffmann Marcus, Povolo Lorenzo, Lommel Mark, Strahl Sabine, Vakhrushev Sergey Y., Rapp Erdmann, Büttner Falk F. R., Halim Adnan, Imberty Anne, Bakker Hans. A bacterial mannose binding lectin as a tool for the enrichment of C- and O-mannosylated peptides. Analytical Chemistry 2022;94(20):7329-7338. https://doi.org/10.1021/acs.analchem.2c00742 BibTeX | RIS | DOI | URL

Abuhattum Shada, Kotzbeck Petra, Schlüßler Raimund, Harger Alexandra, Ariza de Schellenberger Angela, Kim Kyoohyun, Escolano Joan-Carles, Müller Torsten, Braun Jürgen, Wabitsch Martin, Tschöp Matthias, Sack Ingolf, Brankatschk Marko, Guck Jochen, Stemmer Kerstin, Taubenberger Anna V.. Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens. Scientific Reports 2022;12(1):10325. https://doi.org/10.1038/s41598-022-13324-9 PDF | BibTeX | RIS | DOI

Heard Amanda, Landmann Jack H., Hansen Ava R., Papadopolou Alkmini, Hsu Yu-Sung, Selli Mehmet Emrah, Warrington John M., Lattin John, Chang Jufang, Ha Helen, Haug-Kröper Martina, Doray Balraj, Gill Saar, Ruella Marco, Hayer Katharina E., Weitzman Matthew D., Green Abby M., Fluhrer Regina, Singh Nathan. Antigen glycosylation regulates efficacy of CAR T cells targeting CD19. Nature Communications 2022;13(1):3367. https://doi.org/10.1038/s41467-022-31035-7 PDF | BibTeX | RIS | DOI

Seegers Carla I. I., Ramón Roth Isabel, Zarnovican Patricia, Büttner Falk F. R., Routier Françoise H.. Characterization of a gene cluster involved in Aspergillus fumigatus zwitterionic glycosphingolipid synthesis. Glycobiology 2022;32(9):814-824. https://doi.org/10.1093/glycob/cwac036 BibTeX | RIS | DOI

Quarta Carmelo, Stemmer Kerstin, Novikoff Aaron, Yang Bin, Klingelhuber Felix, Harger Alex, Bakhti Mostafa, Bastidas-Ponce Aimee, Baugé Eric, Campbell Jonathan E., Capozzi Megan, Clemmensen Christoffer, Collden Gustav, Cota Perla, Douros Jon, Drucker Daniel J., DuBois Barent, Feuchtinger Annette, Garcia-Caceres Cristina, Grandl Gerald, Hennuyer Nathalie, Herzig Stephan, Hofmann Susanna M., Knerr Patrick J., Kulaj Konxhe, Lalloyer Fanny, Lickert Heiko, Liskiewicz Arek, Liskiewicz Daniela, Maity Gandhari, Perez-Tilve Diego, Prakash Sneha, Sanchez-Garrido Miguel A., Zhang Qian, Staels Bart, Krahmer Natalie, DiMarchi Richard D., Tschöp Matthias H., Finan Brian, Müller Timo D.. GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. Nature Metabolism 2022;4(8):1071-1083. https://doi.org/10.1038/s42255-022-00617-6 PDF | BibTeX | RIS | DOI These authors contributed equally: Carmelo Quarta, Kerstin Stemmer, Aaron Novikoff

Pradhan Pooja, Vijayan Vijith, Cirksena Karsten, Büttner Falk F. R., Igarashi Kazuhiko, Motterlini Roberto, Foresti Roberta, Immenschuh Stephan. Genetic BACH1 deficiency alters mitochondrial function and increases NLRP3 inflammasome activation in mouse macrophages. Redox Biology 2022;51:102265. https://doi.org/10.1016/j.redox.2022.102265 PDF | BibTeX | RIS | DOI

Cumin Cécile, Huang Yen-Lin, Rossdam Charlotte, Ruoff Felix, Céspedes Susana Posada, Liang Ching-Yeu, Lombardo Flavio C., Coelho Ricardo, Rimmer Natalie, Konantz Martina, López Mónica Núñez, Alam Shahidul, Schmidt Alexander, Calabrese Diego, Fedier Andre, Vlajnic Tatjana, von Itzstein Mark, Templin Markus, Büttner Falk F. R., Everest-Dass Arun, Heinzelmann-Schwarz Viola, Jacob Francis. Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways. Cell Reports 2022;40(7):111181. https://doi.org/10.1016/j.celrep.2022.111181 PDF | BibTeX | RIS | DOI

Evers Simon S., Shao Yikai, Ramakrishnan Sadeesh K., Shin Jae Hoon, Bozadjieva-Kramer Nadejda, Irmler Martin, Stemmer Kerstin, Sandoval Darleen A., Shah Yatrik M., Seeley Randy J.. Gut HIF2α signaling is increased after VSG, and gut activation of HIF2α decreases weight, improves glucose, and increases GLP-1 secretion. Cell Reports 2022;38(3):110270. https://doi.org/10.1016/j.celrep.2021.110270 PDF | BibTeX | RIS | DOI

Papadopoulou Alkmini A., Stelzer Walter, Silber Mara, Schlosser Christine, Spitz Charlotte, Haug-Kröper Martina, Straub Tobias, Müller Stephan A., Lichtenthaler Stefan F., Muhle-Goll Claudia, Langosch Dieter, Fluhrer Regina. Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage. Scientific Reports 2022;12(1):20987. https://doi.org/10.1038/s41598-022-24772-8 PDF | BibTeX | RIS | DOI

Janciauskiene Sabina, Tumpara Srinu, Schebb Nils Helge, Büttner Falk F. R., Mainka Malwina, Sivaraman Kokilavani, Immenschuh Stephan, Grau Veronika, Welte Tobias, Olejnicka Beata. Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs. Frontiers in Pharmacology 2022;13:995869. https://doi.org/10.3389/fphar.2022.995869 PDF | BibTeX | RIS | DOI

Mentrup Torben, Stumpff-Niggemann Anna Yamina, Leinung Nadja, Schlosser Christine, Schubert Katja, Wehner Rebekka, Tunger Antje, Schatz Valentin, Neubert Patrick, Gradtke Ann-Christine, Wolf Janina, Rose-John Stefan, Saftig Paul, Dalpke Alexander, Jantsch Jonathan, Schmitz Marc, Fluhrer Regina, Jacobsen Ilse D., Schröder Bernd. Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis. Nature Communications 2022;13(1):1880. https://doi.org/10.1038/s41467-022-29474-3 PDF | BibTeX | RIS | DOI

Beimdiek Julia, Janciauskiene Sabina, Wrenger Sabine, Volland Sonja, Rozy Adriana, Fuge Jan, Olejnicka Beata, Pink Isabell, Illig Thomas, Popov Alexander, Chorostowska Joanna, Büttner Falk F. R., Welte Tobias. Plasma markers of COVID-19 severity: a pilot study. Respiratory Research 2022;23(1):343. https://doi.org/10.1186/s12931-022-02272-7 PDF | BibTeX | RIS | DOI

Bühring-Uhle C., Smit P., Negraschus A., Morath V., Goldmann U., Papadopoulou Alkmini A., Heider M., Riviere J., Götze K., Heinz L., Fluhrer Regina, Moser M., Superti-Furga G., Bassermann F., Eichner R.. SPPL3 and its substrate glycosyltransferases regulate the N-glycosylation of SLC3A2 and alter the affinities of anti-SLC3A2 immunotherapies in AML [Abstract]. Oncology Research and Treatment 2022;45(Supplement 2):95. https://doi.org/10.1159/000526456 PDF | BibTeX | RIS | DOI

Beimdiek Julia, Hennig René, Burock Robert, Puk Oliver, Biskup Saskia, Rapp Erdmann, Lesinski-Schiedat Anke, Büttner Falk F. R., Das Anibh M.. Serum N-glycomics of a novel CDG-IIb patient reveals aberrant IgG glycosylation. Glycobiology 2022;32(5):380-390. https://doi.org/10.1093/glycob/cwac003 BibTeX | RIS | DOI | URL | URL

Wedekind Henri, Beimdiek Julia, Rossdam Charlotte, Kats Elina, Wittek Vanessa, Schumann Lisa, Tiede Andreas, Büttner Falk F. R., Weinhold Birgit, Münster-Kühnel Anja, Abeln Markus. The monosialoganglioside GM1a protects trophoblasts, erythrocytes and endothelial cells against complement attack. preprint; 2022. https://doi.org/10.1101/2022.01.24.477475 BibTeX | RIS | DOI

2021

Aliluev Alexandra, Tritschler Sophie, Sterr Michael, Oppenländer Lena, Hinterdobler Julia, Greisle Tobias, Irmler Martin, Beckers Johannes, Sun Na, Walch Axel, Stemmer Kerstin, Kindt Alida, Krumsiek Jan, Tschöp Matthias H., Luecken Malte D., Theis Fabian J., Lickert Heiko, Böttcher Anika. Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice. Nature Metabolism 2021;3(9):1202-1216. https://doi.org/10.1038/s42255-021-00458-9 PDF | BibTeX | RIS | DOI

Janosz Ewa, Hetzel Miriam, Spielmann Hanna, Tumpara Srinu, Rossdam Charlotte, Schwabbauer Marc, Kloos Doreen, von Kaisenberg Constantin, Schambach Axel, Büttner Falk F. R., Janciauskiene Sabina, Lachmann Nico, Moritz Thomas. Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo. Gene Therapy 2021;28(9):477-493. https://doi.org/10.1038/s41434-021-00269-3 PDF | BibTeX | RIS | DOI

Taubert Richard, Engel Bastian, Diestelhorst Jana, Hupa‐Breier Katharina L., Behrendt Patrick, Baerlecken Niklas T., Sühs Kurt‐Wolfram, Janik Maciej K., Zachou Kalliopi, Sebode Marcial, Schramm Christoph, Londoño María‐Carlota, Habes Sarah, Oo Ye H., Lalanne Claudine, Pape Simon, Schubert Maren, Hust Michael, Dübel Stefan, Thevis Mario, Jonigk Danny, Beimdiek Julia, Büttner Falk F. R., Drenth Joost P. H., Muratori Luigi, Adams David H., Dyson Jessica K., Renand Amédée, Graupera Isabel, Lohse Ansgar W., Dalekos George N., Milkiewicz Piotr, Stangel Martin, Maasoumy Benjamin, Witte Torsten, Wedemeyer Heiner, Manns Michael P., Jaeckel Elmar. Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis. Hepatology 2021;75(1):13-27. https://doi.org/10.1002/hep.32134 PDF | BibTeX | RIS | DOI

Novikoff Aaron, O'Brien Shannon L., Bernecker Miriam, Grandl Gerald, Kleinert Maximilian, Knerr Patrick J., Stemmer Kerstin, Klingenspor Martin, Zeigerer Anja, DiMarchi Richard, Tschöp Matthias H., Finan Brian, Calebiro Davide, Müller Timo D.. Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists. Molecular Metabolism 2021;49. https://doi.org/10.1016/j.molmet.2021.101181 PDF | BibTeX | RIS | DOI

Cirksena Karsten, Hütte Hermann J., Shcherbakova Aleksandra, Thumberger Thomas, Sakson Roman, Weiss Stefan, Jensen Lars Riff, Friedrich Alina, Todt Daniel, Kuss Andreas W., Ruppert Thomas, Wittbrodt Joachim, Bakker Hans, Büttner Falk F. R.. The C-mannosylome of human induced pluripotent stem cells implies a role for ADAMTS16 C-mannosylation in eye development. Molecular and Cellular Proteomics 2021;20:100092. https://doi.org/10.1016/j.mcpro.2021.100092 PDF | BibTeX | RIS | DOI

Zhang Qian, Delessa Challa Tenagne, Augustin Robert, Bakhti Mostafa, Colldén Gustav, Drucker Daniel J., Feuchtinger Annette, Caceres Cristina Garcia, Grandl Gerald, Harger Alexandra, Herzig Stephan, Hofmann Susanna, Holleman Cassie Lynn, Jastroch Martin, Keipert Susanne, Kleinert Maximilian, Knerr Patrick J., Kulaj Konxhe, Legutko Beata, Lickert Heiko, Liu Xue, Luippold Gerd, Lutter Dominik, Malogajski Emilija, Medina Marta Tarquis, Mowery Stephanie A., Blutke Andreas, Perez-Tilve Diego, Salinno Ciro, Sehrer Laura, DiMarchi Richard D., Tschöp Matthias H., Stemmer Kerstin, Finan Brian, Wolfrum Christian, Müller Timo D.. The Glucose-dependent Insulinotropic Polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling. Cell Metabolism 2021;33(4):833-844.e5. https://doi.org/10.1016/j.cmet.2021.01.015 PDF | BibTeX | RIS | DOI

Oppenländer Lena, Palit Subarna, Stemmer Kerstin, Greisle Tobias, Sterr Michael, Salinno Ciro, Bastidas-Ponce Aimée, Feuchtinger Annette, Böttcher Anika, Ansarullah , Theis Fabian J., Lickert Heiko. Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes. Molecular Metabolism 2021;54. https://doi.org/10.1016/j.molmet.2021.101330 PDF | BibTeX | RIS | DOI

2020

Jirmo Adan C., Rossdam Charlotte, Grychtol Ruth, Happle Christine, Gerardy‐Schahn Rita, Büttner Falk F. R., Hansen Gesine. Differential expression patterns of glycosphingolipids and C‐type lectin receptors on immune cells in absence of functional regulatory T cells. Immunity, Inflammation and Disease 2020;8(4):512-522. https://doi.org/10.1002/iid3.334 PDF | BibTeX | RIS | DOI

Dettmer Rabea, Cirksena Karsten, Münchhoff Julia, Kresse Jasmin, Diekmann Ulf, Niwolik Isabell, Büttner Falk F. R., Naujok Ortwin. FGF2 inhibits early pancreatic lineage specification during differentiation of human embryonic stem cells. Cells 2020;9(9):1927. https://doi.org/10.3390/cells9091927 PDF | BibTeX | RIS | DOI

Stemmer Kerstin, Finan Brian, DiMarchi Richard D., Tschöp Matthias H., Müller Timo D.. Insights into incretin-based therapies for treatment of diabetic dyslipidemia. Advanced Drug Delivery Reviews 2020;159:34-53. https://doi.org/10.1016/j.addr.2020.05.008 BibTeX | RIS | DOI

Spitz Charlotte, Schlosser Christine, Guschtschin-Schmidt Nadja, Stelzer Walter, Menig Simon, Götz Alexander, Haug-Kröper Martina, Scharnagl Christina, Langosch Dieter, Muhle-Goll Claudia, Fluhrer Regina. Non-canonical shedding of TNFα by SPPL2a is determined by the conformational flexibility of its transmembrane helix. iScience 2020;23(12):101775. https://doi.org/10.1016/j.isci.2020.101775 PDF | BibTeX | RIS | DOI

Jall Sigrid, De Angelis Meri, Lundsgaard Anne-Marie, Fritzen Andreas M., Nicolaisen Trine S., Klein Anders B., Novikoff Aaron, Sachs Stephan, Richter Erik A., Kiens Bente, Schramm Karl-Werner, Tschöp Matthias H., Stemmer Kerstin, Clemmensen Christoffer, Müller Timo D., Kleinert Maximilian. Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity. Diabetologia 2020;63(6):1236-1247. https://doi.org/10.1007/s00125-020-05117-4 PDF | BibTeX | RIS | DOI

Mentrup Torben, Cabrera-Cabrera Florencia, Fluhrer Regina, Schröder Bernd. Physiological functions of SPP/SPPL intramembrane proteases. Cellular and Molecular Life Sciences 2020;77(15):2959-2979. https://doi.org/10.1007/s00018-020-03470-6 PDF | BibTeX | RIS | DOI

Sachs Stephan, Niu Lili, Geyer Philipp, Jall Sigrid, Kleinert Maximilian, Feuchtinger Annette, Stemmer Kerstin, Brielmeier Markus, Finan Brian, DiMarchi Richard D., Tschöp Matthias H., Wewer Albrechtsen Nicolai, Mann Matthias, Müller Timo D., Hofmann Susanna M.. Plasma proteome profiles treatment efficacy of incretin dual agonism in diet‐induced obese female and male mice. Diabetes, Obesity and Metabolism 2020;23(1):195-207. https://doi.org/10.1111/dom.14215 PDF | BibTeX | RIS | DOI

Klaus Christine, Hansen Jan N., Ginolhac Aurélien, Gérard Deborah, Gnanapragassam Vinayaga S., Horstkorte Rüdiger, Rossdam Charlotte, Büttner Falk F. R., Sauter Thomas, Sinkkonen Lasse, Neumann Harald, Linnartz-Gerlach Bettina. Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice. Neurobiology of Aging 2020;88:91-107. https://doi.org/10.1016/j.neurobiolaging.2020.01.008 PDF | BibTeX | RIS | DOI

Papadopoulou Alkmini A., Fluhrer Regina. Signalling functions of intramembrane aspartyl-proteases. Frontiers in Cardiovascular Medicine 2020;7:591787. https://doi.org/10.3389/fcvm.2020.591787 PDF | BibTeX | RIS | DOI

Fiebig Timm, Cramer Johannes T., Bethe Andrea, Baruch Petra, Curth Ute, Führing Jana I., Büttner Falk F. R., Vogel Ulrich, Schubert Mario, Fedorov Roman, Mühlenhoff Martina. Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A. Nature Communications 2020;11(1). https://doi.org/10.1038/s41467-020-18464-y PDF | BibTeX | RIS | DOI

Starzonek Sarah, Maar Hanna, Labitzky Vera, Wicklein Daniel, Rossdam Charlotte, Büttner Falk F. R., Wolters-Eisfeld Gerrit, Guengoer Cenap, Wagener Christoph, Schumacher Udo, Lange Tobias. Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions. Glycobiology 2020;30(9):695-709. https://doi.org/10.1093/glycob/cwaa019 PDF | BibTeX | RIS | DOI | URL | URL

Fischer Katrin, Fenzl Anna, Liu Dianxin, Dyar Kenneth A., Kleinert Maximilian, Brielmeier Markus, Clemmensen Christoffer, Fedl Anna, Finan Brian, Gessner Andre, Jastroch Martin, Huang Jianfeng, Keipert Susanne, Klingenspor Martin, Brüning Jens C., Kneilling Manfred, Maier Florian C., Othman Ahmed E., Pichler Bernd J., Pramme-Steinwachs Ines, Sachs Stephan, Scheideler Angelika, Thaiss Wolfgang M., Uhlenhaut Henriette, Ussar Siegfried, Woods Stephen C., Zorn Julia, Stemmer Kerstin, Collins Sheila, Diaz-Meco Maria, Moscat Jorge, Tschöp Matthias H., Müller Timo D.. The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Nature Communications 2020;11(1). https://doi.org/10.1038/s41467-020-16230-8 PDF | BibTeX | RIS | DOI

Schriever Sonja C., Kabra Dhiraj G., Pfuhlmann Katrin, Baumann Peter, Baumgart Emily V., Nagler Joachim, Seebacher Fabian, Harrison Luke, Irmler Martin, Kullmann Stephanie, Corrêa-da-Silva Felipe, Giesert Florian, Jain Ruchi, Schug Hannah, Castel Julien, Martinez Sarah, Wu Moya, Häring Hans-Ulrich, de Angelis Martin Hrabe, Beckers Johannes, Müller Timo D., Stemmer Kerstin, Wurst Wolfgang, Rozman Jan, Nogueiras Ruben, De Angelis Meri, Molkentin Jeffery D., Krahmer Natalie, Yi Chun-Xia, Schmidt Mathias V., Luquet Serge, Heni Martin, Tschöp Matthias H., Pfluger Paul T.. Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity. Journal of Clinical Investigation 2020;130(11):6093-6108. https://doi.org/10.1172/jci136363 BibTeX | RIS | DOI

Brugger Manuel S., Baumgartner Kathrin, Mauritz Sophie C. F., Gerlach Stefan C., Röder Florian, Schlosser Christine, Fluhrer Regina, Wixforth Achim, Westerhausen Christoph. Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound healing model. PNAS 2020;117(50):31603-31613. https://doi.org/10.1073/pnas.2005203117 PDF | BibTeX | RIS | DOI

2019

Rossdam Charlotte, Konze Sarah A., Oberbeck Astrid, Rapp Erdmann, Gerardy-Schahn Rita, von Itzstein Mark, Büttner Falk F. R.. Approach for profiling of glycosphingolipid glycosylation by multiplexed capillary gel electrophoresis coupled to laser-induced fluorescence detection To identify cell-surface markers of human pluripotent stem cells and derived cardiomyocytes. Analytical Chemistry 2019;91(10):6413-6418. https://doi.org/10.1021/acs.analchem.9b01114 BibTeX | RIS | DOI

Mentrup Torben, Theodorou Kosta, Cabrera-Cabrera Florencia, Helbig Andreas O., Happ Kathrin, Gijbels Marion, Gradtke Ann-Christine, Rabe Björn, Fukumori Akio, Steiner Harald, Tholey Andreas, Fluhrer Regina, Donners Marjo, Schröder Bernd. Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. Journal of Experimental Medicine 2019;216(4):807-830. https://doi.org/10.1084/jem.20171438 PDF | BibTeX | RIS | DOI

Fluhrer Regina, Hampe Wolfgang, editors. Biochemie hoch 2 und Molekularbiologie. München: Urban & Fischer in Elsevier; 2019. BibTeX | RIS

Albuquerque-Wendt Andreia, Jacot Damien, Dos Santos Pacheco Nicolas, Seegers Carla, Zarnovican Patricia, Büttner Falk F. R., Bakker Hans, Soldati-Favre Dominique, Routier Françoise H.. C-Mannosylation of Toxoplasma gondii proteins promotes attachment to host cells and parasite virulence. Journal of Biological Chemistry 2019;295(4):1066-1076. https://doi.org/10.1074/jbc.ra119.010590 PDF | BibTeX | RIS | DOI

Shcherbakova Aleksandra, Preller Matthias, Taft Manuel H., Pujols Jordi, Ventura Salvador, Tiemann Birgit, Büttner Falk F. R., Bakker Hans. C-mannosylation supports folding and enhances stability of thrombospondin repeats. eLife 2019;8:e52978. https://doi.org/10.7554/elife.52978 PDF | BibTeX | RIS | DOI

Stemmer Kerstin, Müller Timo D., DiMarchi Richard D., Pfluger Paul T., Tschöp Matthias H.. CNS-targeting pharmacological interventions for the metabolic syndrome. Journal of Clinical Investigation 2019;129(10):4058-4071. https://doi.org/10.1172/jci129195 BibTeX | RIS | DOI

Diekmann Ulf, Wolling Hanna, Dettmer Rabea, Niwolik Isabell, Naujok Ortwin, Büttner Falk F. R.. Chemically defined and xenogeneic-free differentiation of human pluripotent stem cells into definitive endoderm in 3D culture. Scientific Reports 2019;9(1). https://doi.org/10.1038/s41598-018-37650-z PDF | BibTeX | RIS | DOI

Müller Günter A., Herling Andreas W., Stemmer Kerstin, Lechner Andreas, Tschöp Matthias H.. Chip-based sensing for release of unprocessed cell surface proteins in vitro and in serum and its (patho)physiological relevance. American Journal of Physiology-Endocrinology and Metabolism 2019;317(2):E212-E233. https://doi.org/10.1152/ajpendo.00079.2019 BibTeX | RIS | DOI

Bastek Heinke, Zubel Tabea, Stemmer Kerstin, Mangerich Aswin, Beneke Sascha, Dietrich Daniel R.. Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity models. Toxicology 2019;420:29-38. https://doi.org/10.1016/j.tox.2019.03.013 BibTeX | RIS | DOI

Müller T.D., Finan B., Bloom S.R., D'Alessio D., Drucker D.J., Flatt P.R., Fritsche A., Gribble F., Grill H.J., Habener J.F., Holst J.J., Langhans W., Meier J.J., Nauck M.A., Perez-Tilve D., Pocai A., Reimann F., Sandoval D.A., Schwartz T.W., Seeley R.J., Stemmer Kerstin, Tang-Christensen M., Woods S.C., DiMarchi R.D., Tschöp M.H.. Glucagon-like peptide 1 (GLP-1). Molecular Metabolism 2019;30:72-130. https://doi.org/10.1016/j.molmet.2019.09.010 PDF | BibTeX | RIS | DOI

Seitz Susanne, Kwon Yun, Hartleben Götz, Jülg Julia, Sekar Revathi, Krahmer Natalie, Najafi Bahar, Loft Anne, Gancheva Sofiya, Stemmer Kerstin, Feuchtinger Annette, Hrabe de Angelis Martin, Müller Timo D., Mann Matthias, Blüher Matthias, Roden Michael, Berriel Diaz Mauricio, Behrends Christian, Gilleron Jerome, Herzig Stephan, Zeigerer Anja. Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity. Nature Metabolism 2019;1(10):1009-1026. https://doi.org/10.1038/s42255-019-0124-x BibTeX | RIS | DOI

Harger A., Stemmer Kerstin, Tschöp M. H., Müller T. D.. Inkretinbasierte Ko- und Triagonisten: innovative Polypharmakologie zur Behandlung von Adipositas und Diabetes. Der Internist 2019;60(9):895-902. https://doi.org/10.1007/s00108-019-0649-9 BibTeX | RIS | DOI

Fluhrer Regina. Intramembrane proteases in neurodegenerative diseases. Open Access Government 2019;(23 (July 2019)):162-164. PDF | BibTeX | RIS | URL

Fluhrer Regina. Intramembrane proteases in the immune system. Open Access Government 2019;(22 (April 2019)):72-73. PDF | BibTeX | RIS | URL

Konze Sarah A., Abraham Wolf-Rainer, Goethe Elke, Surges Esther, Kuypers Marcel M. M., Hoeltig Doris, Meens Jochen, Vogel Charlotte, Stiesch Meike, Valentin-Weigand Peter, Gerlach Gerald-F., Büttner Falk F. R.. Link between heterotrophic carbon fixation and virulence in the porcine lung pathogen Actinobacillus pleuropneumoniae. Infection and Immunity 2019;87(9). https://doi.org/10.1128/iai.00768-18 BibTeX | RIS | DOI

Albuquerque-Wendt Andreia, Hütte Hermann J., Büttner Falk F. R., Routier Françoise H., Bakker Hans. Membrane topological model of glycosyltransferases of the GT-C superfamily. International Journal of Molecular Sciences 2019;20(19):4842. https://doi.org/10.3390/ijms20194842 PDF | BibTeX | RIS | DOI

Niu Lili, Geyer Philipp E, Wewer Albrechtsen Nicolai J, Gluud Lise L, Santos Alberto, Doll Sophia, Treit Peter V, Holst Jens J, Knop Filip K, Vilsbøll Tina, Junker Anders, Sachs Stephan, Stemmer Kerstin, Müller Timo D, Tschöp Matthias H, Hofmann Susanna M, Mann Matthias. Plasma proteome profiling discovers novel proteins associated with non‐alcoholic fatty liver disease. Molecular Systems Biology 2019;15(3):e8793. https://doi.org/10.15252/msb.20188793 PDF | BibTeX | RIS | DOI

Papadopoulou Alkmini A., Müller Stephan A, Mentrup Torben, Shmueli Merav D, Niemeyer Johannes, Haug‐Kröper Martina, von Blume Julia, Mayerhofer Artur, Feederle Regina, Schröder Bernd, Lichtenthaler Stefan F., Fluhrer Regina. Signal peptide peptidase‐like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins. EMBO reports 2019;20(3):e46451. https://doi.org/10.15252/embr.201846451 PDF | BibTeX | RIS | DOI

Niemeyer Johannes, Mentrup Torben, Heidasch Ronny, Müller Stephan A, Biswas Uddipta, Meyer Rieke, Papadopoulou Alkmini A., Dederer Verena, Haug‐Kröper Martina, Adamski Vivian, Lüllmann-Rauch Renate, Bergmann Martin, Mayerhofer Artur, Saftig Paul, Wennemuth Gunther, Jessberger Rolf, Fluhrer Regina, Lichtenthaler Stefan F., Lemberg Marius K, Schröder Bernd. The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban. EMBO Reports 2019;20(3):e46449. https://doi.org/10.15252/embr.201846449 PDF | BibTeX | RIS | DOI

Fluhrer Regina, Schröder Bernd. What is the role of the intramembrane proteases in cancer?. Open Access Government 2019;(23 (October 2019)):184-185. PDF | BibTeX | RIS | URL

2018

van Diepen Laura, Büttner Falk F. R., Hoffmann Dirk, Thiesler Christina T., von Bohlen und Halbach Oliver, von Bohlen und Halbach Viola, Jensen Lars R., Steinemann Doris, Edvardson Simon, Elpeleg Orly, Schambach Axel, Gerardy-Schahn Rita, Kuss Andreas W.. A patient-specific induced pluripotent stem cell model for West syndrome caused by ST3GAL3 deficiency. European Journal of Human Genetics 2018;26(12):1773-1783. https://doi.org/10.1038/s41431-018-0220-5 BibTeX | RIS | DOI

Stumpp Nico S., Konze Sarah A., Gerardy-Schahn Rita, Stiesch Meike, Büttner Falk F. R.. A single-step transconjugation system for gene deletion in Aggregatibacter actinomycetemcomitans. Journal of Microbiological Methods 2018;148:74-77. https://doi.org/10.1016/j.mimet.2018.04.002 BibTeX | RIS | DOI

Fluhrer Regina. A unique family of intramembrane proteases. Scientia 2018;(July 4, 2018). https://doi.org/10.26320/SCIENTIA179 PDF | BibTeX | RIS | DOI | URL

Hoppe Carolin M., Albuquerque-Wendt Andreia, Bandini Giulia, Leon Deborah R., Shcherbakova Aleksandra, Büttner Falk F. R., Izquierdo Luis, Costello Catherine E., Bakker Hans, Routier Françoise H.. Apicomplexan C-mannosyltransferases modify thrombospondin type I-containing adhesins of the TRAP family. Glycobiology 2018;28(5):333-343. https://doi.org/10.1093/glycob/cwy013 BibTeX | RIS | DOI

Rahn Sascha, Zimmermann Vivien, Viol Fabrice, Knaack Hendrike, Stemmer Kerstin, Peters Lena, Lenk Lennart, Ungefroren Hendrik, Saur Dieter, Schäfer Heiner, Helm Ole, Sebens Susanne. Diabetes as risk factor for pancreatic cancer: hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells. Cancer Letters 2018;415:129-150. https://doi.org/10.1016/j.canlet.2017.12.004 BibTeX | RIS | DOI

Fluhrer Regina. Health report: the challenge of cleaving proteins in the membrane. Open Access Government 2018;(20 (October 2018)):38-39. PDF | BibTeX | RIS | URL

Fluhrer Regina. Intramembrane proteases - regulators of cellular pathways. Open Access Government News 2018;(November 21, 2018). PDF | BibTeX | RIS | URL

Brandt S. J., Müller T. D., DiMarchi R. D., Tschöp M. H., Stemmer Kerstin. Peptide-based multi-agonists: a new paradigm in metabolic pharmacology. Journal of Internal Medicine 2018;284(6):581-602. https://doi.org/10.1111/joim.12837 PDF | BibTeX | RIS | DOI

Lichtenthaler Stefan F., Lemberg Marius K., Fluhrer Regina. Proteolytic ectodomain shedding of membrane proteins in mammals - hardware, concepts, and recent developments. EMBO Journal 2018;37(15):e99456. https://doi.org/10.15252/embj.201899456 PDF | BibTeX | RIS | DOI

Wolling Hanna, Konze Sarah A., Höfer Anne, Erdmann Jelena, Pich Andreas, Zweigerdt Robert, Büttner Falk F. R.. Quantitative secretomics reveals extrinsic signals involved in human pluripotent stem cell cardiomyogenesis. PROTEOMICS 2018;18(14):1800102. https://doi.org/10.1002/pmic.201800102 BibTeX | RIS | DOI

Pandey Ashutosh, Li-Kroeger David, Sethi Maya K., Lee Tom V., Büttner Falk F. R., Bakker Hans, Jafar-Nejad Hamed. Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila notch signaling. Glycobiology 2018;28(11):849-859. https://doi.org/10.1093/glycob/cwy080 BibTeX | RIS | DOI

2017

Kommerein Nadine, Stumpp Sascha N., Müsken Mathias, Ehlert Nina, Winkel Andreas, Häussler Susanne, Behrens Peter, Büttner Falk F. R., Stiesch Meike. An oral multispecies biofilm model for high content screening applications. PLOS ONE 2017;12(3). https://doi.org/10.1371/journal.pone.0173973 PDF | BibTeX | RIS | DOI

Böer Ulrike, Büttner Falk F. R., Schridde Ariane, Klingenberg Melanie, Sarikouch Samir, Haverich Axel, Wilhelmi Mathias. Antibody formation towards porcine tissue in patients implanted with crosslinked heart valves is directed to antigenic tissue proteins and αGal epitopes and is reduced in healthy vegetarian subjects. Xenotransplantation 2017;24(2):e12288. https://doi.org/10.1111/xen.12288 BibTeX | RIS | DOI

Jules Felix, Sauvageau Etienne, Dumaresq-Doiron Karine, Mazzaferri Javier, Haug-Kröper Martina, Fluhrer Regina, Costantino Santiago, Lefrancois Stephane. CLN5 is cleaved by members of the SPP/SPPL family to produce a mature soluble protein. Experimental Cell Research 2017;357(1):40-50. https://doi.org/10.1016/j.yexcr.2017.04.024 PDF | BibTeX | RIS | DOI

Diekmann Ulf, Wolling Hanna, Büttner Falk F. R., Naujok Ortwin. Chemisch-definierte und xenogen-freie Differenzierung humaner embryonaler Stammzellen in endodermale und pankreatische Vorläuferzellen. Diabetologie und Stoffwechsel 2017;12(S 01):S1-S84. https://doi.org/10.1055/s-0037-1601586 BibTeX | RIS | DOI

Ryan Karen K, Packard Amy E B, Larson Karlton R, Stout Jayna, Fourman Sarah M, Thompson Abigail M K, Ludwick Kristen, Habegger Kirk M, Stemmer Kerstin, Itoh Nobuyuki, Perez-Tilve Diego, Tschöp Matthias H, Seeley Randy J, Ulrich-Lai Yvonne M. Dietary manipulations that induce ketosis activate the HPA axis in male rats and mice: a potential role for fibroblast growth factor-21. Endocrinology 2017;159(1):400-413. https://doi.org/10.1210/en.2017-00486 BibTeX | RIS | DOI

Scilabra Simone D., Yamamoto Kazuhiro, Pigoni Martina, Sakamoto Kazuma, Müller Stephan A., Papadopoulou Alkmini A., Lichtenthaler Stefan F., Troeberg Linda, Nagase Hideaki, Kadomatsu Kenji. Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a “TRAP” to increase levels of TIMP-3 in the tissue. Matrix Biology 2017;59:69-79. https://doi.org/10.1016/j.matbio.2016.07.004 BibTeX | RIS | DOI

Shcherbakova Aleksandra, Tiemann Birgit, Büttner Falk F. R., Bakker Hans. Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3. Proceedings of the National Academy of Sciences 2017;114(10):2574-2579. https://doi.org/10.1073/pnas.1613165114 BibTeX | RIS | DOI | URL

Pfuhlmann Katrin, Pfluger Paul T., Schriever Sonja C., Müller Timo D., Tschöp Matthias H., Stemmer Kerstin. Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice. PLOS ONE 2017;12(9):e0183488. https://doi.org/10.1371/journal.pone.0183488 PDF | BibTeX | RIS | DOI

Kleinert Maximilian, Clemmensen Christoffer, Stemmer Kerstin, Müller Timo D., DiMarchi Richard D., Tschöp Matthias H.. Emerging poly-agonists for obesity and Type 2 Diabetes. Obesity 2017;25(10):1647-1649. https://doi.org/10.1002/oby.21932 BibTeX | RIS | DOI

Mentrup Torben, Fluhrer Regina, Schröder Bernd. Latest emerging functions of SPP/SPPL intramembrane proteases. European Journal of Cell Biology 2017;96(5):372-382. https://doi.org/10.1016/j.ejcb.2017.03.002 PDF | BibTeX | RIS | DOI

Konze Sarah A., Werneburg Sebastian, Oberbeck Astrid, Olmer Ruth, Kempf Henning, Jara-Avaca Monica, Pich Andreas, Zweigerdt Robert, Büttner Falk F. R.. Proteomic analysis of human pluripotent stem cell cardiomyogenesis revealed altered expression of metabolic enzymes and PDLIM5 isoforms. Journal of Proteome Research 2017;16(3):1133-1149. https://doi.org/10.1021/acs.jproteome.6b00534 BibTeX | RIS | DOI

Konze Sarah A., Cajic Samanta, Oberbeck Astrid, Hennig René, Pich Andreas, Rapp Erdmann, Büttner Falk F. R.. Quantitative assessment of Sialo‐glycoproteins and N‐Glycans during cardiomyogenic differentiation of human induced pluripotent stem cells. ChemBioChem 2017;18(13):1317-1331. https://doi.org/10.1002/cbic.201700100 BibTeX | RIS | DOI

Mentrup Torben, Loock Ann-Christine, Fluhrer Regina, Schröder Bernd. Signal peptide peptidase and SPP-like proteases: possible therapeutic targets?. Biochimica et Biophysica Acta (BBA): Molecular Cell Research 2017;1864(11):2169-2182. https://doi.org/10.1016/j.bbamcr.2017.06.007 PDF | BibTeX | RIS | DOI

Giles Daniel A, Moreno-Fernandez Maria E, Stankiewicz Traci E, Graspeuntner Simon, Cappelletti Monica, Wu David, Mukherjee Rajib, Chan Calvin C, Lawson Matthew J, Klarquist Jared, Sünderhauf Annika, Softic Samir, Kahn C Ronald, Stemmer Kerstin, Iwakura Yoichiro, Aronow Bruce J, Karns Rebekah, Steinbrecher Kris A, Karp Christopher L, Sheridan Rachel, Shanmukhappa Shiva K, Reynaud Damien, Haslam David B, Sina Christian, Rupp Jan, Hogan Simon P, Divanovic Senad. Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. Nature Medicine 2017;23(7):829-838. https://doi.org/10.1038/nm.4346 BibTeX | RIS | DOI Erratum: Nature Medicine 23, 1241 (2017), DOI 10.1038/nm1017-1241c

Klaus Valentina, Bastek Heinke, Damme Katja, Collins Leonard B., Frötschl Roland, Benda Norbert, Lutter Dominik, Ellinger-Ziegelbauer Heidrun, Swenberg James A., Dietrich Daniel R., Stemmer Kerstin. Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats. Archives of Toxicology 2017;91(10):3427-3438. https://doi.org/10.1007/s00204-017-1953-6 BibTeX | RIS | DOI

2016

Maida Adriano, Zota Annika, Sjøberg Kim A., Schumacher Jonas, Sijmonsma Tjeerd P., Pfenninger Anja, Christensen Marie M., Gantert Thomas, Fuhrmeister Jessica, Rothermel Ulrike, Schmoll Dieter, Heikenwälder Mathias, Iovanna Juan L., Stemmer Kerstin, Kiens Bente, Herzig Stephan, Rose Adam J.. A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution. Journal of Clinical Investigation 2016;126(9):3263-3278. https://doi.org/10.1172/jci85946 BibTeX | RIS | DOI

Kempf Henning, Olmer Ruth, Haase Alexandra, Franke Annika, Bolesani Emiliano, Schwanke Kristin, Robles-Diaz Diana, Coffee Michelle, Göhring Gudrun, Dräger Gerald, Pötz Oliver, Joos Thomas, Martinez-Hackert Erik, Haverich Axel, Büttner Falk F. R., Martin Ulrich, Zweigerdt Robert. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nature Communications 2016;7(1):13602. https://doi.org/10.1038/ncomms13602 PDF | BibTeX | RIS | DOI

Finan Brian, Clemmensen Christoffer, Zhu Zhimeng, Stemmer Kerstin, Gauthier Karine, Müller Luisa, De Angelis Meri, Moreth Kristin, Neff Frauke, Perez-Tilve Diego, Fischer Katrin, Lutter Dominik, Sánchez-Garrido Miguel A., Liu Peng, Tuckermann Jan, Malehmir Mohsen, Healy Marc E., Weber Achim, Heikenwalder Mathias, Jastroch Martin, Kleinert Maximilian, Jall Sigrid, Brandt Sara, Flamant Frédéric, Schramm Karl-Werner, Biebermann Heike, Döring Yvonne, Weber Christian, Habegger Kirk M., Keuper Michaela, Gelfanov Vasily, Liu Fa, Köhrle Josef, Rozman Jan, Fuchs Helmut, Gailus-Durner Valerie, Hrabě de Angelis Martin, Hofmann Susanna M., Yang Bin, Tschöp Matthias H., DiMarchi Richard, Müller Timo D.. Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic impact for metabolic disease. Cell 2016;167(3):843-857.e14. https://doi.org/10.1016/j.cell.2016.09.014 BibTeX | RIS | DOI

Thiesler Christina T., Cajic Samanta, Hoffmann Dirk, Thiel Christian, van Diepen Laura, Hennig René, Sgodda Malte, Weiβmann Robert, Reichl Udo, Steinemann Doris, Diekmann Ulf, Huber Nicolas M. B., Oberbeck Astrid, Cantz Tobias, Kuss Andreas W., Körner Christian, Schambach Axel, Rapp Erdmann, Büttner Falk F. R.. Glycomic characterization of induced pluripotent stem cells derived from a patient suffering from phosphomannomutase 2 congenital disorder of glycosylation (PMM2-CDG). Molecular and Cellular Proteomics 2016;15(4):1435-1452. https://doi.org/10.1074/mcp.m115.054122 PDF | BibTeX | RIS | DOI

Kabra Dhiraj G., Pfuhlmann Katrin, García-Cáceres Cristina, Schriever Sonja C., Casquero García Veronica, Kebede Adam Fiseha, Fuente-Martin Esther, Trivedi Chitrang, Heppner Kristy, Uhlenhaut N. Henriette, Legutko Beata, Kabra Uma D., Gao Yuanqing, Yi Chun-Xia, Quarta Carmelo, Clemmensen Christoffer, Finan Brian, Müller Timo D., Meyer Carola W., Paez-Pereda Marcelo, Stemmer Kerstin, Woods Stephen C., Perez-Tilve Diego, Schneider Robert, Olson Eric N., Tschöp Matthias H., Pfluger Paul T.. Hypothalamic leptin action is mediated by histone deacetylase 5. Nature Communications 2016;7(1):10782. https://doi.org/10.1038/ncomms10782 PDF | BibTeX | RIS | DOI

Behrens Wiebke, Schweinitzer Tobias, McMurry Jonathan L., Loewen Peter C., Büttner Falk F. R., Menz Sarah, Josenhans Christine. Localisation and protein-protein interactions of the Helicobacter pylori taxis sensor TlpD and their connection to metabolic functions. Scientific Reports 2016;6(1). https://doi.org/10.1038/srep23582 PDF | BibTeX | RIS | DOI

Werneburg Sebastian, Büttner Falk F. R., Erben Larisser, Mathews Mona, Neumann Harald, Mühlenhoff Martina, Hildebrandt Herbert. Polysialylation and lipopolysaccharide‐induced shedding of E‐selectin ligand‐1 and neuropilin‐2 by microglia and THP‐1 macrophages. Glia 2016;64(8):1314-1330. https://doi.org/10.1002/glia.23004 BibTeX | RIS | DOI

Hüttl Susann, Helfrich F., Mentrup Torben, Held S., Fukumori Akio, Steiner Harald, Saftig Paul, Fluhrer Regina, Schroder B.. Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74. Biochemical Journal 2016;473(10):1405-1422. https://doi.org/10.1042/bcj20160156 PDF | BibTeX | RIS | DOI

2015

Baumann Anna-Maria T., Bakkers Mark J. G., Büttner Falk F. R., Hartmann Maike, Grove Melanie, Langereis Martijn A., de Groot Raoul J., Mühlenhoff Martina. 9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate. Nature Communications 2015;6(1):7673. https://doi.org/10.1038/ncomms8673 PDF | BibTeX | RIS | DOI

Mentrup Torben, Häsler Robert, Fluhrer Regina, Saftig Paul, Schröder Bernd. A cell-based assay reveals nuclear translocation of intracellular domains released by SPPL proteases. Traffic: the international journal of intracellular transport 2015;16(8):871-892. https://doi.org/10.1111/tra.12287 PDF | BibTeX | RIS | DOI

Krüger Anke Tina, Engel Jakob, Büttner Falk F. R., Routier Françoise H.. Aspergillus fumigatus Cap59-like protein A is involved in α1,3-mannosylation of GPI-anchors. Glycobiology 2015;26(1):30-38. https://doi.org/10.1093/glycob/cwv078 BibTeX | RIS | DOI

Engel Jakob, Schmalhorst Philipp S., Krüger Anke Tina, Müller Christina Theda, Büttner Falk F. R., Routier Françoise H. Characterization of an N-acetylglucosaminyltransferase involved in Aspergillus fumigatus zwitterionic glycoinositolphosphoceramide biosynthesis. Glycobiology 2015;25(12):1423-1430. https://doi.org/10.1093/glycob/cwv059 BibTeX | RIS | DOI

Damerow Sebastian, Hoppe Carolin, Bandini Giulia, Zarnovican Patricia, Büttner Falk F. R., Lüder Carsten G. K., Ferguson Michael A. J., Routier Françoise H.. Depletion of UDP-glucose and UDP-galactose using a Degron system leads to growth cessation of Leishmania major. PLOS Neglected Tropical Diseases 2015;9(11):e0004205. https://doi.org/10.1371/journal.pntd.0004205 PDF | BibTeX | RIS | DOI

Karsten Christina B., Büttner Falk F. R., Cajic Samanta, Nehlmeier Inga, Neumann Berit, Klippert Antonina, Sauermann Ulrike, Reichl Udo, Gerardy-Schahn Rita, Rapp Erdmann, Stahl-Hennig Christiane, Pöhlmann Stefan. Exclusive decoration of Simian Immunodeficiency Virus Env with high-mannose type N-glycans is not compatible with mucosal transmission in Rhesus Macaques. Journal of Virology 2015;89(22):11727-11733. https://doi.org/10.1128/jvi.01358-15 PDF | BibTeX | RIS | DOI

Stemmer Kerstin, Zani Fabio, Habegger Kirk M., Neff Christina, Kotzbeck Petra, Bauer Michaela, Yalamanchilli Suma, Azad Ali, Lehti Maarit, Martins Paulo J. F., Müller Timo D., Pfluger Paul T., Seeley Randy J.. FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice. Diabetologia 2015;58(10):2414-2423. https://doi.org/10.1007/s00125-015-3668-7 BibTeX | RIS | DOI

Werneburg S., Büttner Falk F. R., Stangel M., Mühlenhoff M., Hildebrandt H.. ISDN2014_0137: NG2 cells and microglia show cell‐type specific expression of polysialic acid attached to different protein carriers. International Journal of Developmental Neuroscience 2015;47(Part_A):39. https://doi.org/10.1016/j.ijdevneu.2015.04.112 BibTeX | RIS | DOI

Kamp Frits, Winkler Edith, Trambauer Johannes, Ebke Amelie, Fluhrer Regina, Steiner Harald. Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process. Biophysical Journal 2015;108(5):1229-1237. https://doi.org/10.1016/j.bpj.2014.12.045 PDF | BibTeX | RIS | DOI

Damerow Sebastian, Hoppe Carolin, Bandini Giulia, Zarnovican Patricia, Büttner Falk F. R., Ferguson Michael A. J., Routier Françoise H.. Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis. International Journal for Parasitology 2015;45(12):783-790. https://doi.org/10.1016/j.ijpara.2015.06.004 PDF | BibTeX | RIS | DOI

Werneburg Sebastian, Büttner Falk F. R., Mühlenhoff Martina, Hildebrandt Herbert. Polysialic acid modification of the synaptic cell adhesion molecule SynCAM 1 in human embryonic stem cell-derived oligodendrocyte precursor cells. Stem Cell Research 2015;14(3):339-346. https://doi.org/10.1016/j.scr.2015.03.001 PDF | BibTeX | RIS | DOI

Fleck Daniel, Voss Matthias, Brankatschk Ben, Giudici Camilla, Hampel Heike, Schwenk Benjamin, Edbauer Dieter, Fukumori Akio, Steiner Harald, Kremmer Elisabeth, Haug-Kröper Martina, Rossner Moritz J., Fluhrer Regina, Willem Michael, Haass Christian. Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases. Journal of Biological Chemistry 2015;291(1):318-333. https://doi.org/10.1074/jbc.m115.697995 PDF | BibTeX | RIS | DOI

Kuhn Peer-Hendrik, Voss Matthias, Haug-Kröper Martina, Schröder Bernd, Schepers Ute, Bräse Stefan, Haass Christian, Lichtenthaler Stefan F., Fluhrer Regina. Secretome analysis identifies novel signal peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways. Molecular & Cellular Proteomics 2015;14(6):1584-1598. https://doi.org/10.1074/mcp.m115.048298 PDF | BibTeX | RIS | DOI

Dargel Christina, Bassani-Sternberg Michal, Hasreiter Julia, Zani Fabio, Bockmann Jan-Hendrik, Thiele Frank, Bohne Felix, Wisskirchen Karin, Wilde Susanne, Sprinzl Martin F., Schendel Dolores J., Krackhardt Angela M., Uckert Wolfgang, Wohlleber Dirk, Schiemann Matthias, Stemmer Kerstin, Heikenwälder Mathias, Busch Dirk H., Richter Günther, Mann Matthias, Protzer Ulrike. T cells engineered to express a T-cell receptor specific for glypican-3 to recognize and kill hepatoma cells in vitro and in mice. Gastroenterology 2015;149(4):1042-1052. https://doi.org/10.1053/j.gastro.2015.05.055 BibTeX | RIS | DOI

2014

Büttner Falk F. R., Moeller Hanna, Konze Sarah. Analysis of E-cadherin mediated cell-cell interactions in human pluripotent stem cells. Joint Meeting of the Society-for-Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR); November 16–19, 2014; Honolulu, Hawaii ; 2014. BibTeX | RIS

Konze Sarah A., van Diepen Laura, Schröder Anke, Olmer Ruth, Möller Hanna, Pich Andreas, Weißmann Robert, Kuss Andreas W., Zweigerdt Robert, Büttner Falk F. R.. Cleavage of E-Cadherin and β-Catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells. Molecular and Cellular Proteomics 2014;13(4):990-1007. https://doi.org/10.1074/mcp.m113.033423 PDF | BibTeX | RIS | DOI

Büttner Falk F. R., Thiesler Christina Theda, Hoffmann Dirk, Cajic Samanta, Hennig René. Functional characterization of PMM2-CDG patient-derived iPSCs. Joint Meeting of the Society-for-Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR); November 16–19, 2014; Honolulu, Hawaii ; 2014. BibTeX | RIS

Büttner Falk F. R., Werneburg Sebastian, Mühlenhoff Martina, Hildebrandt Herbert. Golgi-resident polysialic acid defines distinct brain cell populations. Joint Meeting of the Society-for-Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR); November 16–19, 2014; Honolulu, Hawaii ; 2014. BibTeX | RIS

Boeer Ulrike, Büttner Falk F. R., Klingenberg Melanie, Antonopoulos Georgios C., Meyer Heiko, Haverich Axel, Wilhelmi Mathias. Immunogenicity of intensively decellularized equine carotid arteries is conferred by the extracellular matrix protein collagen Type VI. PLoS ONE 2014;9(8):e105964. https://doi.org/10.1371/journal.pone.0105964 PDF | BibTeX | RIS | DOI

Fluhrer Regina. Intramembrane cleaving proteases (I-CLiPs) as guardians of shuttling proteins. Cell Cycle 2014;13(5):695-695. https://doi.org/10.4161/cc.28089 PDF | BibTeX | RIS | DOI

Wolf Monika Julia, Adili Arlind, Piotrowitz Kira, Abdullah Zeinab, Boege Yannick, Stemmer Kerstin, Ringelhan Marc, Simonavicius Nicole, Egger Michèle, Wohlleber Dirk, Lorentzen Anna, Einer Claudia, Schulz Sabine, Clavel Thomas, Protzer Ulrike, Thiele Christoph, Zischka Hans, Moch Holger, Tschöp Matthias, Tumanov Alexei V., Haller Dirk, Unger Kristian, Karin Michael, Kopf Manfred, Knolle Percy, Weber Achim, Heikenwalder Mathias. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell 2014;26(4):549-564. https://doi.org/10.1016/j.ccell.2014.09.003 BibTeX | RIS | DOI

Büttner Falk F. R., Thiesler Christina Theda, Hoffmann Dirk, Cajic Samanta, Hennig René. Molecular characterization of hiPSCs from a PMM2-CDG patient revealed aberrant glycosylation. Joint Meeting of the Society-for-Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR); November 16–19, 2014; Honolulu, Hawaii ; 2014. BibTeX | RIS

Voss Matthias, Künzel Ulrike, Higel Fabian, Kuhn Peer‐Hendrik, Colombo Alessio, Fukumori Akio, Haug‐Kröper Martina, Klier Bärbel, Grammer Gudula, Seidl Andreas, Schröder Bernd, Obst Reinhard, Steiner Harald, Lichtenthaler Stefan F., Haass Christian, Fluhrer Regina. Shedding of glycan‐modifying enzymes by signal peptide peptidase‐like 3 (SPPL3) regulates cellular N‐glycosylation. EMBO Journal 2014;33(24):2890-2905. https://doi.org/10.15252/embj.201488375 PDF | BibTeX | RIS | DOI

Schneppenheim Janna, Hüttl Susann, Kruchen Anne, Fluhrer Regina, Müller Ingo, Saftig Paul, Schneppenheim Reinhard, Martin Christa L., Schröder Bernd. Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells. Biochemical and Biophysical Research Communications 2014;451(1):48-53. https://doi.org/10.1016/j.bbrc.2014.07.051 PDF | BibTeX | RIS | DOI

Brockmann Anette, Strittmatter Tobias, May Sarah, Stemmer Kerstin, Marx Andreas, Brunner Thomas. Structure–function relationship of thiazolide-induced apoptosis in colorectal tumor cells. ACS Chemical Biology 2014;9(7):1520-1527. https://doi.org/10.1021/cb500209a BibTeX | RIS | DOI

Schneppenheim Janna, Hüttl Susann, Mentrup Torben, Lüllmann-Rauch Renate, Rothaug M., Engelke Michael, Dittmann Kai, Dressel Ralf, Araki M., Araki K., Wienands Jürgen, Fluhrer Regina, Saftig Paul, Schroder B.. The intramembrane proteases signal peptide peptidase-like 2a and 2b have distinct functions in vivo. Molecular and Cellular Biology 2014;34(8):1398-1411. https://doi.org/10.1128/mcb.00038-14 PDF | BibTeX | RIS | DOI

Stemmer Kerstin, Kotzbeck P, Zani F, Bauer M, Neff C, Müller T D, Pfluger P T, Seeley R J, Divanovic S. Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL/6 nude mice. International Journal of Obesity 2014;39(5):791-797. https://doi.org/10.1038/ijo.2014.187 BibTeX | RIS | DOI

2013

Büttner Falk F. R., Ashikov Angel, Tiemann Birgit, Lehle Ludwig, Bakker Hans. C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats. Molecular Cell 2013;50(2):295-302. https://doi.org/10.1016/j.molcel.2013.03.003 BibTeX | RIS | DOI

Dietrich Daniel R., von Aulock Sonja, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Editorial. Regulatory Toxicology and Pharmacology 2013;67(3):317-320. https://doi.org/10.1016/j.yrtph.2013.07.001 BibTeX | RIS | DOI

Dietrich Daniel R., von Aulock Sonja, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Editorial. Food and Chemical Toxicology 2013;62:A1-A4. https://doi.org/10.1016/j.fct.2013.07.005 BibTeX | RIS | DOI

Habegger K. M., Stemmer Kerstin, Cheng C., Muller T. D., Heppner K. M., Ottaway N., Holland J., Hembree J. L., Smiley D., Gelfanov V., Krishna R., Arafat A. M., Konkar A., Belli S., Kapps M., Woods S. C., Hofmann S. M., D'Alessio D., Pfluger P. T., Perez-Tilve D., Seeley R. J., Konishi M., Itoh N., Kharitonenkov A., Spranger J., DiMarchi R. D., Tschop M. H.. Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes 2013;62(5):1453-1463. https://doi.org/10.2337/db12-1116 PDF | BibTeX | RIS | DOI

Büttner Falk F. R., Karsten Christina B., Nehlmeier Inga, Sauermann Ulrike. Impact of host cell-specific glycosylation differences on SIV infectivity and mucosal transmission. Conference on AIDS Vaccine; 7-10 October 2013; Barcelona, Spain ; 2013. BibTeX | RIS

Bielohuby Maximilian, Sisley Stephanie, Sandoval Darleen, Herbach Nadja, Zengin Ayse, Fischereder Michael, Menhofer Dominik, Stoehr Barbara J. M., Stemmer Kerstin, Wanke Rüdiger, Tschöp Matthias H., Seeley Randy J., Bidlingmaier Martin. Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. American Journal of Physiology-Endocrinology and Metabolism 2013;305(9):E1059-E1070. https://doi.org/10.1152/ajpendo.00208.2013 BibTeX | RIS | DOI

Sethi Maya K., Büttner Falk F. R., Ashikov Angel, Bakker Hans. In vitro assays of orphan glycosyltransferases and their application to identify notch xylosyltransferases. In: Brockhausen Inka, editor. Glycosyltransferases: methods and protocols. Totowa, NJ: Humana Press; 2013. p. 307-320. https://doi.org/10.1007/978-1-62703-465-4_23 BibTeX | RIS | DOI

Voss Matthias, Schröder Bernd, Fluhrer Regina. Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases. Biochimica et Biophysica Acta (BBA): Biomembranes 2013;1828(12):2828-2839. https://doi.org/10.1016/j.bbamem.2013.03.033 PDF | BibTeX | RIS | DOI

Lee Tom V., Sethi Maya K., Leonardi Jessica, Rana Nadia A., Büttner Falk F. R., Haltiwanger Robert S., Bakker Hans, Jafar-Nejad Hamed. Negative regulation of notch signaling by xylose. PLoS Genetics 2013;9(6):e1003547. https://doi.org/10.1371/journal.pgen.1003547 PDF | BibTeX | RIS | DOI

Dietrich Daniel, von Aulock Sonja, Marquardt H. W. J., Blaauboer Bas J., Dekant Wolfgang, Kehrer James, Hengstler Jan G., Collier Abby C., Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Open letter to the European commission: scientifically unfounded precaution drives European commission’s recommendations on EDC regulation, while defying common sense, well-established science, and risk assessment principles. Archives of Toxicology 2013;87(9):1739-1741. https://doi.org/10.1007/s00204-013-1117-2 BibTeX | RIS | DOI

Poggi Marjorie, Kara Imène, Brunel Jean-Michel, Landrier Jean-François, Govers Roland, Bonardo Bernadette, Fluhrer Regina, Haass Christian, Alessi Marie-Christine, Peiretti Franck. Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling. Biochimica et Biophysica Acta (BBA): Molecular Cell Research 2013;1833(3):602-612. https://doi.org/10.1016/j.bbamcr.2012.11.009 PDF | BibTeX | RIS | DOI

Rollenhagen Manuela, Büttner Falk F. R., Reismann Marc, Jirmo Adan Chari, Grove Melanie, Behrens Georg M. N., Gerardy-Schahn Rita, Hanisch Franz-Georg, Mühlenhoff Martina. Polysialic acid on neuropilin-2 is exclusively synthesized by the polysialyltransferase ST8SiaIV and attached to mucin-type O-glycans located between the b2 and c domain. Journal of Biological Chemistry 2013;288(32):22880-22892. https://doi.org/10.1074/jbc.m113.463927 PDF | BibTeX | RIS | DOI

Stemmer Kerstin, Bielohuby Maximilian, Grayson Bernadette E., Begg Denovan P., Chambers Adam P., Neff Christina, Woods Stephen C., Erben Reinhold G., Tschöp Matthias H., Bidlingmaier Martin, Clemens Thomas L., Seeley Randy J.. Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. Endocrinology 2013;154(6):2015-2024. https://doi.org/10.1210/en.2012-2130 BibTeX | RIS | DOI

Dietrich Daniel R., Aulock Sonja von, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan, Barile Frank A.. Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Toxicon 2013;76:A1-A2. https://doi.org/10.1016/j.toxicon.2013.10.020 BibTeX | RIS | DOI

Dietrich Daniel R., Aulock Sonja von, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Barile Frank A., Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Chemico-Biological Interactions 2013;205(1):A1-A5. https://doi.org/10.1016/j.cbi.2013.07.001 BibTeX | RIS | DOI

Dietrich Daniel R., Aulock Sonja von, Marquardt Hans, Blaauboer Bas J., Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Wallace Hayes A., Gooderham Nigel, Harvey Alan. Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Toxicology in Vitro 2013;27(7):2110-2114. https://doi.org/10.1016/j.tiv.2013.07.001 BibTeX | RIS | DOI

Dietrich Daniel R., von Aulock Sonja, Marquardt Hans, Blaauboer Bas, Dekant Wolfgang, Kehrer James, Hengstler Jan, Collier Abby, Gori Gio Batta, Pelkonen Olavi, Lang Florian, Nijkamp Frans P., Stemmer Kerstin, Li Albert, Savolainen Kai, Hayes A. Wallace, Gooderham Nigel, Harvey Alan. Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. ALTEX 2013;30(3):381-385. https://doi.org/10.14573/altex.2013.3.381 PDF | BibTeX | RIS | DOI

Bakker Hans, Büttner Falk F. R., Ashikov Angel. The C‐mannosyltransferase. The FASEB Journal 2013;27(S1):824.2. https://doi.org/10.1096/fasebj.27.1_supplement.824.2 BibTeX | RIS | DOI

Bronckers Antonius LJJ, Gueneli Nur, Lüllmann-Rauch Renate, Schneppenheim Janna, Moraru Andreea P, Himmerkus Nina, Bervoets Theodore J, Fluhrer Regina, Everts Vincent, Saftig Paul, Schröder Bernd. The intramembrane protease SPPL2A is critical for tooth enamel formation. Journal of Bone and Mineral Research 2013;28(7):1622-1630. https://doi.org/10.1002/jbmr.1895 PDF | BibTeX | RIS | DOI

Müller Timo D., Müller Anne, Yi Chun-Xia, M Habegger Kirk, Meyer Carola W., Gaylinn Bruce D., Finan Brian, Heppner Kristy, Trivedi Chitrang, Bielohuby Maximilian, Abplanalp William, Meyer Franziska, Piechowski Carolin L., Pratzka Juliane, Stemmer Kerstin, Holland Jenna, Hembree Jazzmin, Bhardwaj Nakul, Raver Christine, Ottaway Nickki, Krishna Radha, Sah Renu, Sallee Floyd R., Woods Stephen C., Perez-Tilve Diego, Bidlingmaier Martin, Thorner Michael O., Krude Heiko, Smiley David, DiMarchi Richard, Hofmann Susanna, Pfluger Paul T., Kleinau Gunnar, Biebermann Heike, Tschöp Matthias H.. The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nature Communications 2013;4(1):1968. https://doi.org/10.1038/ncomms2968 PDF | BibTeX | RIS | DOI

Zahn Claudia, Kaup Matthias, Fluhrer Regina, Fuchs Hendrik. The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b. FEBS Journal 2013;280(7):1653-1663. https://doi.org/10.1111/febs.12176 PDF | BibTeX | RIS | DOI

2012

Schwarzer David, Büttner Falk F. R., Browning Christopher, Nazarov Sergey, Rabsch Wolfgang, Bethe Andrea, Oberbeck Astrid, Bowman Valorie D., Stummeyer Katharina, Mühlenhoff Martina, Leiman Petr G., Gerardy-Schahn Rita. A multivalent adsorption apparatus explains the broad host range of phage phi92: a comprehensive genomic and structural analysis. Journal of Virology 2012;86(19):10384-10398. https://doi.org/10.1128/jvi.00801-12 BibTeX | RIS | DOI

Keys Timothy G., Freiberger Friedrich, Ehrit Jörg, Krueger Jonas, Eggers Katinka, Büttner Falk F. R., Gerardy-Schahn Rita. A universal fluorescent acceptor for high-performance liquid chromatography analysis of pro- and eukaryotic polysialyltransferases. Analytical Biochemistry 2012;427(2):107-115. https://doi.org/10.1016/j.ab.2012.05.011 BibTeX | RIS | DOI

Brauer Carsten, Hennig-Pauka Isabel, Hoeltig Doris, Büttner Falk F. R., Beyerbach Martin, Gasse Hagen, Gerlach Gerald-F., Waldmann Karl-H.. Experimental Actinobacillus pleuropneumoniae challenge in swine: comparison of computed tomographic and radiographic findings during disease. BMC Veterinary Research 2012;8(1):47. https://doi.org/10.1186/1746-6148-8-47 PDF | BibTeX | RIS | DOI

Voss Matthias, Fukumori Akio, Kuhn Peer-Hendrik, Künzel Ulrike, Klier Bärbel, Grammer Gudula, Haug-Kröper Martina, Kremmer Elisabeth, Lichtenthaler Stefan F., Steiner Harald, Schröder Bernd, Haass Christian, Fluhrer Regina. Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3). Journal of Biological Chemistry 2012;287(52):43401-43409. https://doi.org/10.1074/jbc.m112.371369 PDF | BibTeX | RIS | DOI

Stemmer Kerstin, Perez-Tilve Diego, Ananthakrishnan Gayathri, Bort Anja, Seeley Randy J., Tschöp Matthias H., Dietrich Daniel R., Pfluger Paul T.. High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney. Disease Models and Mechanisms 2012;5(5):627-635. https://doi.org/10.1242/dmm.009407 PDF | BibTeX | RIS | DOI | URL | URL

Okle Oliver, Stemmer Kerstin, Deschl Ulrich, Dietrich Daniel R.. L-BMAA induced ER stress and enhanced caspase 12 cleavage in human neuroblastoma SH-SY5Y cells at low nonexcitotoxic concentrations. Toxicological Sciences 2012;131(1):217-224. https://doi.org/10.1093/toxsci/kfs291 BibTeX | RIS | DOI

Ashikov A., Büttner Falk F. R., Tiemann B., Gerardy-Schahn R., Bakker H.. LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE. Glycobiology 2012;23(3):303-309. https://doi.org/10.1093/glycob/cws153 BibTeX | RIS | DOI

Sethi Maya K., Büttner Falk F. R., Ashikov Angel, Krylov Vadim B., Takeuchi Hideyuki, Nifantiev Nikolay E., Haltiwanger Robert S., Gerardy-Schahn Rita, Bakker Hans. Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch. Journal of Biological Chemistry 2012;287(4):2739-2748. https://doi.org/10.1074/jbc.m111.302406 PDF | BibTeX | RIS | DOI

Finan Brian, Yang Bin, Ottaway Nickki, Stemmer Kerstin, Müller Timo D, Yi Chun-Xia, Habegger Kirk, Schriever Sonja C, García-Cáceres Cristina, Kabra Dhiraj G, Hembree Jazzminn, Holland Jenna, Raver Christine, Seeley Randy J, Hans Wolfgang, Irmler Martin, Beckers Johannes, de Angelis Martin Hrabě, Tiano Joseph P, Mauvais-Jarvis Franck, Perez-Tilve Diego, Pfluger Paul, Zhang Lianshan, Gelfanov Vasily, DiMarchi Richard D, Tschöp Matthias H. Targeted estrogen delivery reverses the metabolic syndrome. Nature Medicine 2012;18(12):1847-1856. https://doi.org/10.1038/nm.3009 BibTeX | RIS | DOI

Schneppenheim Janna, Dressel Ralf, Hüttl Susann, Lüllmann-Rauch Renate, Engelke Michael, Dittmann Kai, Wienands Jürgen, Eskelinen Eeva-Liisa, Hermans-Borgmeyer Irm, Fluhrer Regina, Saftig Paul, Schröder Bernd. The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain. Journal of Experimental Medicine 2012;210(1):41-58. https://doi.org/10.1084/jem.20121069 PDF | BibTeX | RIS | DOI

Müller Timo D., Lee Sang Jun, Jastroch Martin, Kabra Dhiraj, Stemmer Kerstin, Aichler Michaela, Abplanalp Bill, Ananthakrishnan Gayathri, Bhardwaj Nakul, Collins Sheila, Divanovic Senad, Endele Max, Finan Brian, Gao Yuanqing, Habegger Kirk M., Hembree Jazzmin, Heppner Kristy M., Hofmann Susanna, Holland Jenna, Küchler Daniela, Kutschke Maria, Krishna Radha, Lehti Maarit, Oelkrug Rebecca, Ottaway Nickki, Perez-Tilve Diego, Raver Christine, Walch Axel K., Schriever Sonja C., Speakman John, Tseng Yu-Hua, Diaz-Meco Maria, Pfluger Paul T., Moscat Jorge, Tschöp Matthias H.. p62 Links β-adrenergic input to mitochondrial function and thermogenesis. Journal of Clinical Investigation 2012;123(1):469-478. https://doi.org/10.1172/jci64209 BibTeX | RIS | DOI

2011

Stemmer Kerstin, Dietrich Daniel R.. Application of laser-capture microdissection to study renal carcinogenesis. In: Murray Graeme I., editor. Laser capture microdissection. Totowa, NJ: Humana Press; 2011. p. 279-290. https://doi.org/10.1007/978-1-61779-163-5_23 BibTeX | RIS | DOI

Bielohuby Maximilian, Stemmer Kerstin, Berger José, Ramisch Juliane, Smith Kathleen, Holland Jenna, Parks Kenneth, Pfluger Paul T., Habegger Kirk M., Tschöp Matthias H., Seeley Randy J., Bidlingmaier Martin. Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats. Obesity Surgery 2011;22(1):140-151. https://doi.org/10.1007/s11695-011-0528-5 BibTeX | RIS | DOI

Feurstein Daniel, Stemmer Kerstin, Kleinteich Julia, Speicher Tobias, Dietrich Daniel R. Microcystin congener– and concentration-dependent induction of murine neuron apoptosis and neurite degeneration. Toxicological Sciences 2011;124(2):424-431. https://doi.org/10.1093/toxsci/kfr243 BibTeX | RIS | DOI

Büttner Falk F. R., Konze Sarah A., Maas Alexander, Gerlach Gerald F.. Proteomic and immunoproteomic characterization of a DIVA subunit vaccine against Actinobacillus pleuropneumoniae. Proteome Science 2011;9(1):23. https://doi.org/10.1186/1477-5956-9-23 PDF | BibTeX | RIS | DOI

Fluhrer Regina, Kamp Frits, Grammer Gudula, Nuscher Brigitte, Steiner Harald, Beyer Klaus, Haass Christian. The nicastrin ectodomain adopts a highly thermostable structure. Biological Chemistry 2011;392(11):995-1001. https://doi.org/10.1515/bc.2011.169 PDF | BibTeX | RIS | DOI

Fluhrer Regina, Martin Lucas, Klier Bärbel, Haug-Kröper Martina, Grammer Gudula, Nuscher Brigitte, Haass Christian. The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). Journal of Biological Chemistry 2011;287(7):5156-5163. https://doi.org/10.1074/jbc.m111.328104 PDF | BibTeX | RIS | DOI

2010

Sethi Maya K., Büttner Falk F. R., Krylov Vadim B., Takeuchi Hideyuki, Nifantiev Nikolay E., Haltiwanger Robert S., Gerardy-Schahn Rita, Bakker Hans. Identification of glycosyltransferase 8 Family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats. Journal of Biological Chemistry 2010;285(3):1582-1586. https://doi.org/10.1074/jbc.c109.065409 PDF | BibTeX | RIS | DOI

Büttner Falk F. R., Sethi Maya. Identification of the Xylosyltransferase adding the second Xylose to O-glucosylated notch EGF repeats. Annual Conference of the Society for Glycobiology; November 7 – 10, 2010; St. Pete Beach, FL ; 2010. BibTeX | RIS

Bielohuby Maximilian, Menhofer Dominik, Kirchner Henriette, Stoehr Barbara J. M., Müller Timo D., Stock Peggy, Hempel Madlen, Stemmer Kerstin, Pfluger Paul T., Kienzle Ellen, Christ Bruno, Tschöp Matthias H., Bidlingmaier Martin. Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein. American Journal of Physiology: Endocrinology and Metabolism 2010;300(1):E65-E76. https://doi.org/10.1152/ajpendo.00478.2010 BibTeX | RIS | DOI

Feurstein Daniel, Kleinteich Julia, Heussner Alexandra H., Stemmer Kerstin, Dietrich Daniel R.. Investigation of microcystin congener–dependent uptake into primary murine neurons. Environmental Health Perspectives 2010;118(10):1370-1375. https://doi.org/10.1289/ehp.0901289 BibTeX | RIS | DOI

Büttner Falk F. R., Sethi Maya. Notch Xylosyltransferases. Annual Conference of the Society for Glycobiology; November 7 – 10, 2010; St. Pete Beach, FL ; 2010. BibTeX | RIS

Ullrich Sylvia, Münch Anna, Neumann Stephanie, Kremmer Elisabeth, Tatzelt Jörg, Lichtenthaler Stefan F.. The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. Journal of Biological Chemistry 2010;285(27):20664-20674. https://doi.org/10.1074/jbc.m109.055608 PDF | BibTeX | RIS | DOI

Fischer A., Hoeger S.J., Stemmer Kerstin, Feurstein D.J., Knobeloch D., Nussler A., Dietrich D.R.. The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: a comparison of primary human hepatocytes and OATP-transfected HEK293 cells. Toxicology and Applied Pharmacology 2010;245(1):9-20. https://doi.org/10.1016/j.taap.2010.02.006 BibTeX | RIS | DOI

Fukumori Akio, Fluhrer Regina, Steiner Harald, Haass Christian. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis. Journal of Neuroscience 2010;30(23):7853-7862. https://doi.org/10.1523/jneurosci.1443-10.2010 PDF | BibTeX | RIS | DOI

2009

Büttner Falk F. R., Bendalla Ibrahim M., Bossé Janine T., Meens Jochen, Nash John H. E., Härtig Elisabeth, Langford Paul R., Gerlach Gerald‐F.. Analysis of the Actinobacillus pleuropneumoniae HlyX (FNR) regulon and identification of iron‐regulated protein B as an essential virulence factor. PROTEOMICS 2009;9(9):2383-2398. https://doi.org/10.1002/pmic.200800439 BibTeX | RIS | DOI

Godemann Robert, Madden James, Krämer Joachim, Smith Myron, Fritz Ulrike, Hesterkamp Thomas, Barker John, Höppner Sabine, Hallett David, Cesura Andrea, Ebneth Andreas, Kemp John. Fragment-based discovery of BACE1 inhibitors using functional assays. Biochemistry 2009;48(45):10743-10751. https://doi.org/10.1021/bi901061a PDF | BibTeX | RIS | DOI

Kahlisch Dennis, Büttner Falk F. R., Naim Hassan Y., Gerlach Gerald-Friedrich. Glycoprotein analysis of porcine bronchoalveolar lavage fluid reveals potential biomarkers corresponding to resistance to Actinobacillus pleuropneumoniae infection. Veterinary Research 2009;40(6):60. https://doi.org/10.1051/vetres/2009043 PDF | BibTeX | RIS | DOI

Fluhrer Regina, Steiner Harald, Haass Christian. Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases. Journal of Biological Chemistry 2009;284(21):13975-13979. https://doi.org/10.1074/jbc.r800040200 PDF | BibTeX | RIS | DOI

Fluhrer Regina, Haass Christian. Intramembrane proteolysis by γ-secretase and signal peptide peptidases. In: Intracellular traffic and neurodegenerative disorders. Berlin [u.a.]: Springer; 2009. p. 11-26. https://doi.org/10.1007/978-3-540-87941-1_2 PDF | BibTeX | RIS | DOI

Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Ahr Hans-Jürgen, Dietrich Daniel R.. Molecular characterization of preneoplastic lesions provides insight on the development of renal tumors. The American Journal of Pathology 2009;175(4):1686-1698. https://doi.org/10.2353/ajpath.2009.081071 BibTeX | RIS | DOI

Martin Lucas, Fluhrer Regina, Haass Christian. Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. Journal of Biological Chemistry 2009;284(9):5662-5670. https://doi.org/10.1074/jbc.m807485200 PDF | BibTeX | RIS | DOI

2008

Schöbel Susanne, Neumann Stephanie, Hertweck Maren, Dislich Bastian, Kuhn Peer-Hendrik, Kremmer Elisabeth, Seed Brian, Baumeister Ralf, Haass Christian, Lichtenthaler Stefan F.. A novel sorting nexin modulates endocytic trafficking and α-secretase cleavage of the amyloid precursor protein. Journal of Biological Chemistry 2008;283(21):14257-14268. https://doi.org/10.1074/jbc.m801531200 PDF | BibTeX | RIS | DOI

Büttner Falk F. R., Maas Alexander, Gerlach Gerald-F.. An Actinobacillus pleuropneumoniae arcA deletion mutant is attenuated and deficient in biofilm formation. Veterinary Microbiology 2008;127(1-2):106-115. https://doi.org/10.1016/j.vetmic.2007.08.005 BibTeX | RIS | DOI

Büttner Falk F. R., Bendallah Ibrahim M., Bosse Janine T., Dreckmann Karla, Nash John H. E., Langford Paul R., Gerlach Gerald-F.. Analysis of the Actinobacillus pleuropneumoniae ArcA regulon identifies fumarate reductase as a determinant of virulence. Infection and Immunity 2008;76(6):2284-2295. https://doi.org/10.1128/iai.01540-07 BibTeX | RIS | DOI

Steiner Harald, Fluhrer Regina, Haass Christian. Intramembrane proteolysis by γ-secretase. Journal of Biological Chemistry 2008;283(44):29627-29631. https://doi.org/10.1074/jbc.r800010200 PDF | BibTeX | RIS | DOI

Fluhrer Regina, Fukumori Akio, Martin Lucas, Grammer Gudula, Haug-Kröper Martina, Klier Bärbel, Winkler Edith, Kremmer Elisabeth, Condron Margaret M., Teplow David B., Steiner Harald, Haass Christian. Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. Journal of Biological Chemistry 2008;283(44):30121-30128. https://doi.org/10.1074/jbc.m806092200 PDF | BibTeX | RIS | DOI

2007

Prager Kai, Wang-Eckhardt Lihua, Fluhrer Regina, Killick Richard, Barth Esther, Hampel Heike, Haass Christian, Walter Jochen. A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling. Journal of Biological Chemistry 2007;282(19):14083-14093. https://doi.org/10.1074/jbc.m608437200 PDF | BibTeX | RIS | DOI

Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Ahr Hans-Juergen, Dietrich Daniel R.. Carcinogen-specific gene expression profiles in short-term treated eker and wild-type rats indicative of pathways involved in renal tumorigenesis. Cancer Research 2007;67(9):4052-4068. https://doi.org/10.1158/0008-5472.can-06-3587 BibTeX | RIS | DOI

Martin Lucas, Fluhrer Regina, Reiss Karina, Kremmer Elisabeth, Saftig Paul, Haass Christian. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. Journal of Biological Chemistry 2007;283(3):1644-1652. https://doi.org/10.1074/jbc.m706661200 PDF | BibTeX | RIS | DOI

Baltes Nina, Büttner Falk F. R., Gerlach Gerald-F.. Selective capture of transcribed sequences (SCOTS) of Actinobacillus pleuropneumoniae in the chronic stage of disease reveals an HlyX-regulated autotransporter protein. Veterinary Microbiology 2007;123(1-3):110-121. https://doi.org/10.1016/j.vetmic.2007.03.026 BibTeX | RIS | DOI

Fluhrer Regina, Haass Christian. Signal peptide peptidases and gamma-secretase: cousins of the same protease family?. Neurodegenerative Diseases 2007;4(2-3):112-116. https://doi.org/10.1159/000101835 PDF | BibTeX | RIS | DOI

2006

Fluhrer Regina, Grammer Gudula, Israel Lars, Condron Margaret M., Haffner Christof, Friedmann Elena, Böhland Claudia, Imhof Axel, Martoglio Bruno, Teplow David B., Haass Christian. A γ-secretase-like intramembrane cleavage of TNFα by the GxGD aspartyl protease SPPL2b. Nature Cell Biology 2006;8(8):894-896. https://doi.org/10.1038/ncb1450 PDF | BibTeX | RIS | DOI

Neumann Stephanie, Schöbel Susanne, Jäger Sebastian, Trautwein Anna, Haass Christian, Pietrzik Claus U., Lichtenthaler Stefan F.. Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein. Journal of Biological Chemistry 2006;281(11):7583-7594. https://doi.org/10.1074/jbc.m508340200 PDF | BibTeX | RIS | DOI

Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Lotz Kerstin, Ahr Hans-J., Dietrich Daniel R.. Establishment of a protocol for the gene expression analysis of laser microdissected rat kidney samples with affymetrix genechips. Toxicology and Applied Pharmacology 2006;217(1):134-142. https://doi.org/10.1016/j.taap.2006.07.012 BibTeX | RIS | DOI

Schöbel Susanne, Neumann Stephanie, Seed Brian, Lichtenthaler Stefan F.. Expression cloning screen for modifiers of amyloid precursor protein shedding. International Journal of Developmental Neuroscience 2006;24(2-3):141-148. https://doi.org/10.1016/j.ijdevneu.2005.11.003 PDF | BibTeX | RIS | DOI

Larivière Laurent, Geiger Sebastian, Hoeppner Sabine, Röther Susanne, Sträßer Katja, Cramer Patrick. Structure and TBP binding of the Mediator head subcomplex Med8–Med18–Med20. Nature Structural & Molecular Biology 2006;13(10):895-901. https://doi.org/10.1038/nsmb1143 PDF | BibTeX | RIS | DOI

2005

Baumli Sonja, Hoeppner Sabine, Cramer Patrick. A conserved mediator hinge revealed in the structure of the MED7·MED21 (Med7·Srb7) heterodimer. Journal of Biological Chemistry 2005;280(18):18171-18178. https://doi.org/10.1074/jbc.m413466200 PDF | BibTeX | RIS | DOI

Meinhart Anton, Kamenski Tomislav, Hoeppner Sabine, Baumli Sonja, Cramer Patrick. A structural perspective of CTD function. Genes & Development 2005;19(12):1401-1415. https://doi.org/10.1101/gad.1318105 PDF | BibTeX | RIS | DOI

Baltes Nina, N′diaye Mohamed, Jacobsen Ilse D., Maas Alexander, Büttner Falk F. R., Gerlach Gerald-F.. Deletion of the anaerobic regulator HlyX causes reduced colonization and persistence of Actinobacillus pleuropneumoniae in the porcine respiratory tract. Infection and Immunity 2005;73(8):4614-4619. https://doi.org/10.1128/iai.73.8.4614-4619.2005 BibTeX | RIS | DOI

Krawitz Peter, Haffner Christof, Fluhrer Regina, Steiner Harald, Schmid Bettina, Haass Christian. Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. Journal of Biological Chemistry 2005;280(47):39515-39523. https://doi.org/10.1074/jbc.m501645200 PDF | BibTeX | RIS | DOI

Hoeppner Sabine, Baumli Sonja, Cramer Patrick. Structure of the Mediator subunit cyclin C and its implications for CDK8 function. Journal of Molecular Biology 2005;350(5):833-842. https://doi.org/10.1016/j.jmb.2005.05.041 PDF | BibTeX | RIS | DOI

Höppner Christoph, Carle Anna, Sivanesan Durga, Hoeppner Sabine, Baron Christian. The putative lytic transglycosylase VirB1 from Brucella suis interacts with the type IV secretion system core components VirB8, VirB9 and VirB11. Microbiology 2005;151(11):3469-3482. https://doi.org/10.1099/mic.0.28326-0 PDF | BibTeX | RIS | DOI

2003

Fluhrer Regina, Multhaup Gerd, Schlicksupp Andrea, Okochi Masayasu, Takeda Masatoshi, Lammich Sven, Willem Michael, Westmeyer Gil, Bode Wolfram, Walter Jochen, Haass Christian. Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation. Journal of Biological Chemistry 2003;278(8):5531-5538. https://doi.org/10.1074/jbc.m211485200 PDF | BibTeX | RIS | DOI

Fluhrer Regina, Friedlein Arno, Haass Christian, Walter Jochen. Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. Journal of Biological Chemistry 2003;279(3):1585-1593. https://doi.org/10.1074/jbc.m306653200 PDF | BibTeX | RIS | DOI

Fluhrer Regina. Zwei neuartige Aspartylproteasen BACE-1 und BACE-2: Charakterisierung und Vergleich der katalytischen Spezifitäten bei der Proteolyse des Alzheimer-β-Amyloid-Vorläufer-Proteins. München: Ludwig-Maximilians-Universität München; 2003. PDF | BibTeX | RIS | URL München, Univ., Diss., 2003

2002

Fluhrer Regina, Capell Anja, Westmeyer Gil, Willem Michael, Hartung Bianka, Condron Margaret M., Teplow David B., Haass Christian, Walter Jochen. A non-amyloidogenic function of BACE-2 in the secretory pathway. Journal of Neurochemistry 2002;81(5):1011-1020. https://doi.org/10.1046/j.1471-4159.2002.00908.x PDF | BibTeX | RIS | DOI

Capell Anja, Meyn Liane, Fluhrer Regina, Teplow David B., Walter Jochen, Haass Christian. Apical sorting of beta-secretase limits amyloid beta-peptide production. Journal of Biological Chemistry 2002;277(7):5637-5643. https://doi.org/10.1074/jbc.m109119200 PDF | BibTeX | RIS | DOI

2001

Walter Jochen, Fluhrer Regina, Hartung Bianka, Willem Michael, Kaether Christoph, Capell Anja, Lammich Sven, Multhaup Gerd, Haass Christian. Phosphorylation regulates intracellular trafficking of beta-secretase. Journal of Biological Chemistry 2001;276(18):14634-14641. https://doi.org/10.1074/jbc.m011116200 PDF | BibTeX | RIS | DOI

Barbero Pierre, Buell Erin, Zulley Stephanie, Pfeffer Suzanne R.. TIP47 is not a component of lipid droplets. Journal of Biological Chemistry 2001;276(26):24348-24351. https://doi.org/10.1074/jbc.m102468200 PDF | BibTeX | RIS | DOI