Biochemistry and Molecular Biology

  1. University
  2. Faculties
  3. Faculty of Medicine
  4. Chairs and professorships
  5. Biochemistry and Molecular Biology
  6. Team Prof. Dr. Regina Fluhrer
  7. Dr. Sabine Höppner

Dr. Sabine Höppner

Research Coordinator and Group Leader
Biochemistry and Molecular Biology
Phone: +49 (0) 821 598-71119
Email:
Room: 1.03.53 (Business Campus München)
Address: Parkring 11-13, 85748 Garching

RESEARCH FOCUSES

Vita

Since 2022

Principal Investigator at the Chair of Biochemistry and Molecular Biology

 

Since July 2019

Research Coordinator at the Chair of Biochemistry and Molecular Biology, Faculty of Medicine, University of Augsburg

 

Since 2016

Secondary occupation as an author and illustrator for Elsevier Verlag, textbook "Biochemistry hoch 2"

 

February 2015 – June 2019

Director of Protein Science, Proteros GmbH Martinsried

 

February 2015 – September 2016

Director of Business Planning and Development, Proteros GmbH München

 

September 2013 – June 2019

Lecturer Biochemistry for medical students, LMU Munich

 

December 2011

Bachelor's degree in Business Administration, Fernuniversität Hagen

 

November 2006 – July 2013

Scientific Project Manager at Proteros GmbH, Martinsried

 

December 2005 – November 2006

Head of Protein Production and Crystallization, Crenano GmbH, Martinsried

 

October 2005

Ph.D. in Biochemistry, specializing in Protein Crystallography

 

September 2001 – September 2005

Research Associate at the Genzentrum, LMU Munich, Prof. Patrick Cramer

 

November 1995 – June 2001

Student of Biology at LMU Munich and Universidad de Concepción, Chile (with DAAD scholarship)

 

Publications

2024 | 2023 | 2009 | 2006 | 2005

2024
Sharrouf Kinda, Schlosser Christine, Mildenberger Sandra, Fluhrer Regina, Hoeppner Sabine. In vitro cleavage of tumor necrosis factor α (TNFα) by Signal-Peptide-Peptidase-like 2b (SPPL2b) resembles mechanistic principles observed in the cellular context. Chemico-Biological Interactions 2024;395:111006. https://doi.org/10.1016/j.cbi.2024.111006
PDF | BibTeX | RIS | DOI

2023
Hoeppner Sabine, Schröder Bernd, Fluhrer Regina. Structure and function of SPP/SPPL proteases: insights from biochemical evidence and predictive modeling. The FEBS Journal 2023;290(23):5456-5474. https://doi.org/10.1111/febs.16968
PDF | BibTeX | RIS | DOI

2009
Godemann Robert, Madden James, Krämer Joachim, Smith Myron, Fritz Ulrike, Hesterkamp Thomas, Barker John, Höppner Sabine, Hallett David, Cesura Andrea, Ebneth Andreas, Kemp John. Fragment-based discovery of BACE1 inhibitors using functional assays. Biochemistry 2009;48(45):10743-10751. https://doi.org/10.1021/bi901061a
PDF | BibTeX | RIS | DOI

2006
Larivière Laurent, Geiger Sebastian, Hoeppner Sabine, Röther Susanne, Sträßer Katja, Cramer Patrick. Structure and TBP binding of the Mediator head subcomplex Med8–Med18–Med20. Nature Structural & Molecular Biology 2006;13(10):895-901. https://doi.org/10.1038/nsmb1143
PDF | BibTeX | RIS | DOI

2005
Baumli Sonja, Hoeppner Sabine, Cramer Patrick. A conserved mediator hinge revealed in the structure of the MED7·MED21 (Med7·Srb7) heterodimer. Journal of Biological Chemistry 2005;280(18):18171-18178. https://doi.org/10.1074/jbc.m413466200
PDF | BibTeX | RIS | DOI
Meinhart Anton, Kamenski Tomislav, Hoeppner Sabine, Baumli Sonja, Cramer Patrick. A structural perspective of CTD function. Genes & Development 2005;19(12):1401-1415. https://doi.org/10.1101/gad.1318105
PDF | BibTeX | RIS | DOI
Hoeppner Sabine, Baumli Sonja, Cramer Patrick. Structure of the Mediator subunit cyclin C and its implications for CDK8 function. Journal of Molecular Biology 2005;350(5):833-842. https://doi.org/10.1016/j.jmb.2005.05.041
PDF | BibTeX | RIS | DOI
Höppner Christoph, Carle Anna, Sivanesan Durga, Hoeppner Sabine, Baron Christian. The putative lytic transglycosylase VirB1 from Brucella suis interacts with the type IV secretion system core components VirB8, VirB9 and VirB11. Microbiology 2005;151(11):3469-3482. https://doi.org/10.1099/mic.0.28326-0
PDF | BibTeX | RIS | DOI

Search