Biochemistry and Molecular Biology

  1. University
  2. Faculties
  3. Faculty of Medicine
  4. Chairs and professorships
  5. Biochemistry and Molecular Biology
  6. Team Prof. Dr. Regina Fluhrer
  7. Dr. Alkmini Papadopoulou

Dr. Alkmini Papadopoulou

Postdoctoral Researcher
Biochemistry and Molecular Biology
Phone: +49 (0) 821 598-71106
Email:
Room: 1.03.09 (Business Campus München)
Address: Parkring 11-13, 85748 Garching

Research Focuses

 

Investigating the physiological regulation of SPPL3 protein expression under starvation conditions and how that is connected to different nutrient sensing pathways. We are using multiple cell culture models and a variety of biochemistry techniques to figure out this complicated regulation mechanism.

Vita

Since January 2020

Post Doctoral Researcher, University of Augsburg, Augsburg, Germany

 

October 2019 – December 2019

Post Doctoral Researcher, Ludwig-Maximilians University, Munich, Germany

 

July 2014 – September 2019

PhD Candidate, International Max Planck Research School of Life Sciences and Ludwig-Maximilians University, Munich, Germany

Final Grade “Summa cum Laude”

 

October 2013 – June 2014

Postgraduate Research Student, Graduate School of Medicine, Nagoya University, Japan

 

September 2007 – July 2013

Diploma in Pharmacy, School of Pharmacy, Aristotle University of Thessaloniki, Greece

Final Grade 7.53/10 (rating: very good, top 10% of faculty graduates)

 

September 2001 – June 2007

Anatolia College of Thessaloniki, “Greek-American High School”

Final Grade 19.3/20 (rating: excellent)

 

Memberships

  • Member of „Gesellschaft für Biochemie und Molekularbiologie e.V.“ (GBM)

Publications

2023 | 2022 | 2020 | 2019 | 2017

2023
Smit P., Buehring-Uhle C., Nather C., Negraschus A., Goldmann U., Papadopoulou Alkmini A., Riviere J., Morath V., Henkel E., Bromberger T., Goetze K., Heinz L., Fluhrer Regina, Moser M., Superti-Furga G., Bassermann F., Eichner R.. Inhibiting MGAT1-mediated N-glycosylation reduces proliferation and adhesion of AML cells and increases affinities of anti-SLC3A2 directed immunotherapies [Abstract]. Oncology Research and Treatment 2023;46(Suppl. 5):191. https://doi.org/10.1159/000533576
PDF | BibTeX | RIS | DOI

2022
Heard Amanda, Landmann Jack H., Hansen Ava R., Papadopolou Alkmini, Hsu Yu-Sung, Selli Mehmet Emrah, Warrington John M., Lattin John, Chang Jufang, Ha Helen, Haug-Kröper Martina, Doray Balraj, Gill Saar, Ruella Marco, Hayer Katharina E., Weitzman Matthew D., Green Abby M., Fluhrer Regina, Singh Nathan. Antigen glycosylation regulates efficacy of CAR T cells targeting CD19. Nature Communications 2022;13(1):3367. https://doi.org/10.1038/s41467-022-31035-7
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Papadopoulou Alkmini A., Stelzer Walter, Silber Mara, Schlosser Christine, Spitz Charlotte, Haug-Kröper Martina, Straub Tobias, Müller Stephan A., Lichtenthaler Stefan F., Muhle-Goll Claudia, Langosch Dieter, Fluhrer Regina. Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage. Scientific Reports 2022;12(1):20987. https://doi.org/10.1038/s41598-022-24772-8
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Bühring-Uhle C., Smit P., Negraschus A., Morath V., Goldmann U., Papadopoulou Alkmini A., Heider M., Riviere J., Götze K., Heinz L., Fluhrer Regina, Moser M., Superti-Furga G., Bassermann F., Eichner R.. SPPL3 and its substrate glycosyltransferases regulate the N-glycosylation of SLC3A2 and alter the affinities of anti-SLC3A2 immunotherapies in AML [Abstract]. Oncology Research and Treatment 2022;45(Supplement 2):95. https://doi.org/10.1159/000526456
PDF | BibTeX | RIS | DOI

2020
Papadopoulou Alkmini A., Fluhrer Regina. Signalling functions of intramembrane aspartyl-proteases. Frontiers in Cardiovascular Medicine 2020;7:591787. https://doi.org/10.3389/fcvm.2020.591787
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2019
Papadopoulou Alkmini A., Müller Stephan A, Mentrup Torben, Shmueli Merav D, Niemeyer Johannes, Haug‐Kröper Martina, von Blume Julia, Mayerhofer Artur, Feederle Regina, Schröder Bernd, Lichtenthaler Stefan F., Fluhrer Regina. Signal peptide peptidase‐like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins. EMBO reports 2019;20(3):e46451. https://doi.org/10.15252/embr.201846451
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Niemeyer Johannes, Mentrup Torben, Heidasch Ronny, Müller Stephan A, Biswas Uddipta, Meyer Rieke, Papadopoulou Alkmini A., Dederer Verena, Haug‐Kröper Martina, Adamski Vivian, Lüllmann-Rauch Renate, Bergmann Martin, Mayerhofer Artur, Saftig Paul, Wennemuth Gunther, Jessberger Rolf, Fluhrer Regina, Lichtenthaler Stefan F., Lemberg Marius K, Schröder Bernd. The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban. EMBO Reports 2019;20(3):e46449. https://doi.org/10.15252/embr.201846449
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2017
Scilabra Simone D., Yamamoto Kazuhiro, Pigoni Martina, Sakamoto Kazuma, Müller Stephan A., Papadopoulou Alkmini A., Lichtenthaler Stefan F., Troeberg Linda, Nagase Hideaki, Kadomatsu Kenji. Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a “TRAP” to increase levels of TIMP-3 in the tissue. Matrix Biology 2017;59:69-79. https://doi.org/10.1016/j.matbio.2016.07.004
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