In diesem Sommersemester wird die im WiSe 2022/23 erfolgreich gestartete Vortragsreihe Medical Information Sciences fortgesetzt. Renommierte Wissenschaftlerinnen und Wissenschaftler unterschiedlicher Fachdisziplinen und Forschungsstandorte geben jeden Dienstag ab 17:30 Uhr Einblicke in aktuelle Fragestellungen und Anwendungsgebiete des breiten Forschungsfeldes Medical Information Sciences.

How can positron emission tomography and modelling techniques be used to quantify receptor availability in the brain? Positron emission tomography (PET) is an imaging technique that can be used to visualise metabolic processes. Small amounts of a radioactively labelled molecule that is involved in a metabolic pathway of interest are administered into the body. Radioligands that bind specifically to neuroreceptors are used for neurological or psychiatric issues. Compartment models can be used to obtain quantitative physiological parameters. Usually, a complex imaging protocol is required, which, in addition to the collection of tissue data by PET, also requires arterial blood data as input function for kinetic models. Using the endocannabinoid system as an example, it is shown how PET and modelling methods can be used to address translational and hypothesis-driven questions.